General information for g635.t18
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial .
Parent gene
- The parent gene g635 is located on chr_3: 4682651..4683238 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g635 | g635.t18 | isoform | g635.t18 | 4681659 | 4683238 |
| chr_3 | g635 | g635.t18 | exon | g635.t18.exon1 | 4681659 | 4682071 |
| chr_3 | g635 | g635.t18 | cds | g635.t18.CDS1 | 4681835 | 4682071 |
| chr_3 | g635 | g635.t18 | exon | g635.t18.exon2 | 4682134 | 4682439 |
| chr_3 | g635 | g635.t18 | cds | g635.t18.CDS2 | 4682134 | 4682439 |
| chr_3 | g635 | g635.t18 | exon | g635.t18.exon3 | 4682523 | 4683238 |
| chr_3 | g635 | g635.t18 | cds | g635.t18.CDS3 | 4682523 | 4682657 |
| chr_3 | g635 | g635.t18 | TTS | g635.t18 | 4683211 | 4683211 |
| chr_3 | g635 | g635.t18 | TSS | g635.t18 | NA | NA |
Sequences
>g635.t18 Gene=g635 Length=1435
CACCACCTGCTGCATCAACACCTCCACCACCGCCTCCAAAACCAGCAGCACCAGCAAAAA
CCGTTCCAATTGCTGCCATTCGACATGCACAAGCTATCGATGCTGCCACAGTTAAAGTAC
CTCCAGCTGATTATACAAAAGAAATCACTGGCACACGCACGGAACAGCGTGTAAAAATGA
ATCGAATGCGTCTAAAGATTGCATCACGTTTGAAGGAAGCACAAAATGTCAATGCAATGT
TAACAACATTCAATGAAATTGATATGAGTGCAATCATGGAATTCCGCAAGTTGCATCAAG
AAACCTTCCAAAAGCGTTATGGAATTAAATTAGGATTTATGTCAGCTTTCTGTAAAGCTG
CTGCTTATGCTCTTCAAGATCAACCAGTTGTTAATGCTGTTATTGAAGATAATGAAATTG
TTTATCGTGATTATGTTGATATTTCGGTTGCTGTTGCATCACCAAAAGGTTTAGTTGTGC
CAGTTTTGCGTAATGTAGAATCAATGAATTATGCTGAAATTGAATTGGGTATCAATGCTT
TGGGCGAGAAAGCTCGTAATGGAACATTAGCTGTTGAAGATATGGACGGTGGTACTTTTA
CAATCAGTAATGGAGGCGTATTTGGTTCACTAATGGGTACTCCAATTATTAATCCACCAC
AAAGTGCTATTCTCGGTATGCACGCAACATTTGAGCGACCAGTGGCTATCAAAGGACAAG
TCGTTATTCGTCCCATGATGTACATCGCACTTACGTATGATCATCGTTTGATTGATGGAC
GTGAGGCTGTGACTTTCTTGCGTAAAATCAAAGCAGGTGTCGAAGATCCAAGAATCATCT
TGGCTGGCGTTTAAATAATTAACTGAAATGCTTGCACTATACGAGCGCATCGGACATACA
AAAAACAATATTTTTCGGTGAAATTTACTTACACTTAGGGCATATCTTTTTTTCTTCATT
TGAACAATTCGACTTCAATAATAAAACCACAAGATGAATCTTTAAAATGTTAATTTAATA
GTAAAAAAAGAATAAGCCGAGAGATAAAGATAAATTATTGACATAAACAAAAAACACTCG
AGAGAAAGTAATTTGTATTAATGATGTGCACCATCGAGTTTATATAAGTTGAATATCAAA
ATCTGATCTATATCTATTGATGATAATAGACAAGACATTATCTACCTATTGATTATTATT
ATTAACTATATACGAATCTTTATTGCAATTCAATTTTGGCCGAGAAATGAAAGAAAAACC
TCAACTCATTTCCCTAAATAATTTTTTTTGTGAAAAAATCGAAAAAGAGGATAAATGCAG
GATAGCGTCATAAAAATCACATTTAGTTCGACAACAATAAAATAATTTATTTAAAGTTTT
AAAATAAAAAAAATAATTTGCAAAAATAAAGAAAAACTTTTTAAGAATCAAAATG
>g635.t18 Gene=g635 Length=225
MNRMRLKIASRLKEAQNVNAMLTTFNEIDMSAIMEFRKLHQETFQKRYGIKLGFMSAFCK
AAAYALQDQPVVNAVIEDNEIVYRDYVDISVAVASPKGLVVPVLRNVESMNYAEIELGIN
ALGEKARNGTLAVEDMDGGTFTISNGGVFGSLMGTPIINPPQSAILGMHATFERPVAIKG
QVVIRPMMYIALTYDHRLIDGREAVTFLRKIKAGVEDPRIILAGV
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 5 | g635.t18 | Gene3D | G3DSA:3.30.559.10 | Chloramphenicol Acetyltransferase | 1 | 224 | 0 |
| 2 | g635.t18 | PANTHER | PTHR43416 | DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED | 1 | 222 | 0 |
| 3 | g635.t18 | PANTHER | PTHR43416:SF18 | DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL | 1 | 222 | 0 |
| 1 | g635.t18 | Pfam | PF00198 | 2-oxoacid dehydrogenases acyltransferase (catalytic domain) | 1 | 221 | 0 |
| 4 | g635.t18 | SUPERFAMILY | SSF52777 | CoA-dependent acyltransferases | 1 | 222 | 0 |
| 6 | g635.t18 | TIGRFAM | TIGR01347 | sucB: dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase (succinyl-transferring) complex | 1 | 222 | 0 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0006099 | tricarboxylic acid cycle | BP |
| GO:0045252 | oxoglutarate dehydrogenase complex | CC |
| GO:0016746 | acyltransferase activity | MF |
| GO:0004149 | dihydrolipoyllysine-residue succinyltransferase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K00658 (2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase))
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed