Gene loci information

Transcript annotation

  • This transcript has been annotated as Tyrosine-protein kinase Btk29A.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_2 g6519 g6519.t2 TSS g6519.t2 17447857 17447857
chr_2 g6519 g6519.t2 isoform g6519.t2 17448462 17454732
chr_2 g6519 g6519.t2 exon g6519.t2.exon1 17448462 17448614
chr_2 g6519 g6519.t2 cds g6519.t2.CDS1 17448462 17448614
chr_2 g6519 g6519.t2 exon g6519.t2.exon2 17449291 17449386
chr_2 g6519 g6519.t2 cds g6519.t2.CDS2 17449291 17449386
chr_2 g6519 g6519.t2 exon g6519.t2.exon3 17449451 17449580
chr_2 g6519 g6519.t2 cds g6519.t2.CDS3 17449451 17449580
chr_2 g6519 g6519.t2 exon g6519.t2.exon4 17449649 17449795
chr_2 g6519 g6519.t2 cds g6519.t2.CDS4 17449649 17449795
chr_2 g6519 g6519.t2 exon g6519.t2.exon5 17451905 17452107
chr_2 g6519 g6519.t2 cds g6519.t2.CDS5 17451905 17452107
chr_2 g6519 g6519.t2 exon g6519.t2.exon6 17452726 17452860
chr_2 g6519 g6519.t2 cds g6519.t2.CDS6 17452726 17452860
chr_2 g6519 g6519.t2 exon g6519.t2.exon7 17452943 17453023
chr_2 g6519 g6519.t2 cds g6519.t2.CDS7 17452943 17453023
chr_2 g6519 g6519.t2 exon g6519.t2.exon8 17453080 17453210
chr_2 g6519 g6519.t2 cds g6519.t2.CDS8 17453080 17453210
chr_2 g6519 g6519.t2 exon g6519.t2.exon9 17453272 17453594
chr_2 g6519 g6519.t2 cds g6519.t2.CDS9 17453272 17453594
chr_2 g6519 g6519.t2 exon g6519.t2.exon10 17453659 17453999
chr_2 g6519 g6519.t2 cds g6519.t2.CDS10 17453659 17453999
chr_2 g6519 g6519.t2 exon g6519.t2.exon11 17454062 17454235
chr_2 g6519 g6519.t2 cds g6519.t2.CDS11 17454062 17454235
chr_2 g6519 g6519.t2 exon g6519.t2.exon12 17454295 17454358
chr_2 g6519 g6519.t2 cds g6519.t2.CDS12 17454295 17454358
chr_2 g6519 g6519.t2 exon g6519.t2.exon13 17454424 17454557
chr_2 g6519 g6519.t2 cds g6519.t2.CDS13 17454424 17454557
chr_2 g6519 g6519.t2 exon g6519.t2.exon14 17454634 17454732
chr_2 g6519 g6519.t2 cds g6519.t2.CDS14 17454634 17454732
chr_2 g6519 g6519.t2 TTS g6519.t2 17455296 17455296

Sequences

>g6519.t2 Gene=g6519 Length=2211
ATGAGTGAGACAACAATGTTGGTTGAACCAACTTTGATGATAAAACGTAGTCAAAACAAA
AAGAGATGGTCTCTAATAAATTATAAGACAAGATTGTTTGAATTGTCGCGAACACATTTG
GTTTATTTTGACAATATCGATGGGGGCAAGGAGAAACGTAGAGAAAGAGGACGCATTGAC
GTGCGCGGCATCAAACTAGTGGAACCTGCAATTTTACACGGTGATGGAGGCGATGTTCAT
GCTCCAAATGGATATCCTTTTCAAATAGGCTATTCAGAGAACGGCATAAATAGTAATAGC
ACAGTACCAACTTTCACCCTATATCTCGTTGCTGCCACAGATAAAGAAAGAAGTGAATGG
ATTAGAGCAATAAGAAAAGTCAGTGAAGATTATTCACCAAAATCATTTCGATATCATCCG
GGATTGTTTAAAATCAATAAATGGTCTTGCTGTAAAAACACAAGTCGAACTGCACTTGGC
TGTCTGGTGACAACTAGTTGGCCGGAAAAAAATAATAATTATAAAAATAACGGAAATAAT
AACTCACCAAGCCAGAATTCAACTCGAAGTACTAGTCCTAATAGAACCAATAACAATAAT
AGCACTAGCAGCGGTCATATACAAAAAGTCTCATCTCAAACACAAATACAACTACAAGGT
TCTCCGCAACAGCAACTGCAGAGTCACACATTATTAAATAACTCAACTCCATTCAACTCT
CCTCATCAGACATCGTTAAATAACTTTAAATCGCCATCACTTAACGGAAGTGGTAACTGT
CAGCACGTTGACATGCCTATGCCAGGAAGTACAGGAACTACAACCACAACAACTTCAGCA
ATTCCACCGCCTGGAACACCAAAGGATGGAACAGGACGATTAAAAATAGTTGTGGCACTA
TATCCATTTAAAGCAATAGAGACTGGAGATTTATCATTAGAAAAGAATGCTGAATATGAA
GTTATTGATGATTCACAAGAGCATTGGTGGAAAGTTAAAGATTCATCTGGAAATATCGGT
TACATTCCATCAAATTATGTAAAAGAAAAAGAACTTTTAGGCCTACAGAAATATGATTGG
TATGTCGGCGACATGTCGAGACAGCGTGCAGAGTCATTATTAAAGCAAAATGACAAAGAA
GGCTGCTTCGTGGTTCGCAAGTCATCAACAAAAGGTCTATACACACTCTCGTTACACACC
AAAGTTCCGCAATCGCATGTCAAGCACTATCATATTAAGCAAAATGCACGAGGAGAATTT
TATTTAAGCGAAAAACACTGCTGTGAAACTATTCCCGATCTTATCAACTATCATCGACAC
AATTCCGGTGGATTAGCGTGTCGATTAAAAGTTTCGCCATGTGATCGTCCTGTTCCGCCC
ACTGCCGGTCTTAGTCATGATAAATGGGAAATTCATCCATCTGAACTAATGATACTTGAA
GAACTCGGTTCGGGCCAATTTGGTGTTGTTCGTCGTGCTAAATGGCGCGGATCAATTGAT
ACTGCTGTTAAAATGATGAAAGTCGGAACAATGTCGGAAGATGATTTTATTGAAGAAGCG
AAAGTCATGACTAAATTGCAACATCCTAATCTTGTGCAGCTTTATGGTGTATGCAGCAAA
CATCGTCCAATTTATATCATTACTGAATATATGAAGCATGGTTCGCTATTAAATTATTTA
AGAAGACACGAACAGTCATTAATTGGCAATATGGGATTACTTTTGGATATGTGCATACAA
GTTTGCAAAGGAATGTCCTATTTAGAGCGTCATAATTATATTCATCGCGATTTAGCAGCT
CGTAATTGTTTAGTCGGCAGCGAAAATACAGTAAAAGTGGCAGACTTTGGTTTAGCTCGT
TATGTGCTTGATGACCAATATACATCTTCAGGCGGTACAAAGTTTCCCATAAAGTGGGCA
CCTCCAGAGGTCTTAAACTACACAAGATTCTCCTCGAAGTCTGACGTTTGGGCATATGGT
GTTTTAATGTGGGAAGTTTTTACTTGTGGCAAAATGCCATACGGTCGCCTAAAAAATACC
GAAGTTGTTGAAAGAGTTCAGCGTGGAATAATTTTAGAGAAACCAAAAGCATGTGCAAAA
GAAATTTATGATGTAATGAGAAAGTGCTGGTCTCATGGCCCGGAAGATCGACCGAGCTTT
CGTTTACTAAAAGATCAACTTGCGACTGTAGCACAAGGATTAACCGACTAA

>g6519.t2 Gene=g6519 Length=736
MSETTMLVEPTLMIKRSQNKKRWSLINYKTRLFELSRTHLVYFDNIDGGKEKRRERGRID
VRGIKLVEPAILHGDGGDVHAPNGYPFQIGYSENGINSNSTVPTFTLYLVAATDKERSEW
IRAIRKVSEDYSPKSFRYHPGLFKINKWSCCKNTSRTALGCLVTTSWPEKNNNYKNNGNN
NSPSQNSTRSTSPNRTNNNNSTSSGHIQKVSSQTQIQLQGSPQQQLQSHTLLNNSTPFNS
PHQTSLNNFKSPSLNGSGNCQHVDMPMPGSTGTTTTTTSAIPPPGTPKDGTGRLKIVVAL
YPFKAIETGDLSLEKNAEYEVIDDSQEHWWKVKDSSGNIGYIPSNYVKEKELLGLQKYDW
YVGDMSRQRAESLLKQNDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARGEF
YLSEKHCCETIPDLINYHRHNSGGLACRLKVSPCDRPVPPTAGLSHDKWEIHPSELMILE
ELGSGQFGVVRRAKWRGSIDTAVKMMKVGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSK
HRPIYIITEYMKHGSLLNYLRRHEQSLIGNMGLLLDMCIQVCKGMSYLERHNYIHRDLAA
RNCLVGSENTVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYG
VLMWEVFTCGKMPYGRLKNTEVVERVQRGIILEKPKACAKEIYDVMRKCWSHGPEDRPSF
RLLKDQLATVAQGLTD

Protein features from InterProScan

Transcript Database ID Name Start End E.value
26 g6519.t2 CDD cd11768 SH3_Tec_like 296 349 1.85519E-29
28 g6519.t2 CDD cd09934 SH2_Tec_family 353 455 1.4132E-66
27 g6519.t2 CDD cd05059 PTKc_Tec_like 471 728 7.86977E-177
23 g6519.t2 Gene3D G3DSA:2.30.29.30 - 2 170 1.7E-32
22 g6519.t2 Gene3D G3DSA:2.30.30.40 SH3 Domains 289 351 3.3E-19
25 g6519.t2 Gene3D G3DSA:3.30.505.10 SHC Adaptor Protein 352 462 3.9E-32
24 g6519.t2 Gene3D G3DSA:1.10.510.10 Transferase(Phosphotransferase) domain 1 469 733 4.8E-95
35 g6519.t2 MobiDBLite mobidb-lite consensus disorder prediction 172 227 -
6 g6519.t2 PANTHER PTHR24418 TYROSINE-PROTEIN KINASE 275 731 2.9E-201
7 g6519.t2 PANTHER PTHR24418:SF219 TYROSINE-PROTEIN KINASE TEC 275 731 2.9E-201
11 g6519.t2 PRINTS PR00401 SH2 domain signature 360 374 2.1E-8
8 g6519.t2 PRINTS PR00401 SH2 domain signature 380 390 2.1E-8
12 g6519.t2 PRINTS PR00401 SH2 domain signature 391 402 2.1E-8
9 g6519.t2 PRINTS PR00401 SH2 domain signature 406 416 2.1E-8
10 g6519.t2 PRINTS PR00401 SH2 domain signature 427 441 2.1E-8
15 g6519.t2 PRINTS PR00109 Tyrosine kinase catalytic domain signature 548 561 1.4E-35
13 g6519.t2 PRINTS PR00109 Tyrosine kinase catalytic domain signature 587 605 1.4E-35
17 g6519.t2 PRINTS PR00109 Tyrosine kinase catalytic domain signature 635 645 1.4E-35
14 g6519.t2 PRINTS PR00109 Tyrosine kinase catalytic domain signature 654 676 1.4E-35
16 g6519.t2 PRINTS PR00109 Tyrosine kinase catalytic domain signature 698 720 1.4E-35
3 g6519.t2 Pfam PF00169 PH domain 13 128 2.2E-11
4 g6519.t2 Pfam PF00779 BTK motif 137 166 5.5E-11
1 g6519.t2 Pfam PF00018 SH3 domain 298 344 1.2E-13
2 g6519.t2 Pfam PF00017 SH2 domain 360 438 5.8E-22
5 g6519.t2 Pfam PF07714 Protein tyrosine and serine/threonine kinase 477 727 4.0E-96
34 g6519.t2 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 482 504 -
33 g6519.t2 ProSitePatterns PS00109 Tyrosine protein kinases specific active-site signature. 593 605 -
40 g6519.t2 ProSiteProfiles PS50003 PH domain profile. 6 129 12.098
37 g6519.t2 ProSiteProfiles PS51113 Zinc finger Btk-type profile. 131 167 13.383
36 g6519.t2 ProSiteProfiles PS50002 Src homology 3 (SH3) domain profile. 292 352 25.566
38 g6519.t2 ProSiteProfiles PS50001 Src homology 2 (SH2) domain profile. 360 454 20.622
39 g6519.t2 ProSiteProfiles PS50011 Protein kinase domain profile. 476 730 40.852
31 g6519.t2 SMART SM00233 PH_update 12 131 3.8E-11
30 g6519.t2 SMART SM00326 SH3_2 295 351 4.4E-18
32 g6519.t2 SMART SM00252 SH2_5 358 444 1.6E-30
29 g6519.t2 SMART SM00219 tyrkin_6 476 727 2.3E-137
18 g6519.t2 SUPERFAMILY SSF50729 PH domain-like 13 164 7.0E-26
21 g6519.t2 SUPERFAMILY SSF50044 SH3-domain 289 351 3.07E-17
20 g6519.t2 SUPERFAMILY SSF55550 SH2 domain 328 451 4.84E-32
19 g6519.t2 SUPERFAMILY SSF56112 Protein kinase-like (PK-like) 466 727 6.83E-79

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0004713 protein tyrosine kinase activity MF
GO:0005524 ATP binding MF
GO:0005515 protein binding MF
GO:0004672 protein kinase activity MF
GO:0006468 protein phosphorylation BP
GO:0035556 intracellular signal transduction BP

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values