Gene loci information

Transcript annotation

  • This transcript has been annotated as Probable multidrug resistance-associated protein lethal(2)03659.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_2 g6968 g6968.t1 TSS g6968.t1 20222230 20222230
chr_2 g6968 g6968.t1 isoform g6968.t1 20222748 20226935
chr_2 g6968 g6968.t1 exon g6968.t1.exon1 20222748 20223443
chr_2 g6968 g6968.t1 cds g6968.t1.CDS1 20222748 20223443
chr_2 g6968 g6968.t1 exon g6968.t1.exon2 20223504 20223561
chr_2 g6968 g6968.t1 cds g6968.t1.CDS2 20223504 20223561
chr_2 g6968 g6968.t1 exon g6968.t1.exon3 20223629 20223708
chr_2 g6968 g6968.t1 cds g6968.t1.CDS3 20223629 20223708
chr_2 g6968 g6968.t1 exon g6968.t1.exon4 20223763 20225364
chr_2 g6968 g6968.t1 cds g6968.t1.CDS4 20223763 20225364
chr_2 g6968 g6968.t1 exon g6968.t1.exon5 20225424 20225589
chr_2 g6968 g6968.t1 cds g6968.t1.CDS5 20225424 20225589
chr_2 g6968 g6968.t1 exon g6968.t1.exon6 20225654 20226846
chr_2 g6968 g6968.t1 cds g6968.t1.CDS6 20225654 20226846
chr_2 g6968 g6968.t1 exon g6968.t1.exon7 20226909 20226935
chr_2 g6968 g6968.t1 cds g6968.t1.CDS7 20226909 20226935
chr_2 g6968 g6968.t1 TTS g6968.t1 20226990 20226990

Sequences

>g6968.t1 Gene=g6968 Length=3822
ATGGAATCACTGAATTCTAAGAAACAATTACCACCGAGCCCAAGAGAAAAAGCAAATTTA
ATTTCATACATAACATTTGCATGGGCTATTCCAATATTCTTAAAAGGCAGAAATCAAACA
ATTGGCGATGATGACTTATTTCAACCGTTGAATGAGCAAAAAGCAAGTGGCTTAGCAAAT
AAAATAAAAGATTCGTGGAATAAAGAAGAAGAAAAATGTAGGAAAGATAATAAGAAACCA
TGGCTTGTTAGCGTATTGAGAAGAGTTTTTGGTTATGAAGTTCTTTTTCAAGGACTTTTC
CTTCTTTTCATTGAATGTGGATTAAAAATTCTACCTCCAATTTTTCTTAATCAAATAATT
AAATATCATGAAAATAAAGATAAAGAAAGTGAAGCAGTTATGTATTGGAGTACTTTTGGC
ATCACTTTGTGTATTTTTTTCAATGTCATAATTATGCATGCCTTCAACTTGAGTAACTTA
AATTTGGGACTTAAAATGAGAATTGCTGTTAGTACCTTGATTTATGATAAATGTTTACAA
TTATCAAAAAGTTCACTTGCAAATGTAAGCTTAGGAAAAATTGTAAATCTTTTGTCAAGT
GATGTTGGAAGATTCGATTCAACAGCTTTTGGATTTCATTATTTATGGGTTGGTCCAATT
CAAACAATTTTTGTTACATATTTAATTTATAATGAGATTGGTTGGTCAGCATTTGGTGGA
GTTGCATTAATTTTATTAATGATTCCATTGCAATTATTTCTTGGAAAAACAACAGCAATG
TTGAGAATGAAAACTGCATTAAGAACTGATAAAAGAATCAAATTGATGAATGAAATAATA
CAAGGAATTCAAACAATTAAAATGTATGCATGGGAAAAGCCAATGGCAGCATTGATATCA
CAAACCCGAGGAAAAGAAATTCGAATGATACGATTTGTTTCATGGATCAAGGGTATAACG
CTATCACTCATGCTATTTTCATCACGCGTTTCAATTTTTACAAGTTTGATTCTGTTTGCA
ATTTTGGGAAATTTACTCACCGCACAAAAAGCATTCGTGGTTACTGCATATTACAATGTC
TTGAGGCAAACTATGGTGATAATGTATCCTTTAGCAATCAATAATGTTGCGGAATGTCGT
GTTGCTATTCAGAGAATTCAGCAGCTGCTGTTTATTACTGATACAAACAATAATGAGAAA
CAAAATAAATGCCCAAAAATATCGAGTGCATCGACCTATATAAAAATGCGAAAAGTATTT
GCAAAATGGAACAGTCAATCACCTGAAATGACTTTAACTGATATCAATATAGATATTTCA
TCACCATCATTAAACATTGTTGTCGGTAGAGTAGGTTCTGGTAAATCTAATATGATTCAA
GCTATTTTAAATGAACTTCCAATTGAGACAGGAGAAATTGATGTTAATGGAAAAATTTCA
TATGCATCACAAGTGCCATGGTTATTTTCTGGTTCTGTTAAACAAAATATTGTTTTTGGA
CTTCCATTTGACAAAAATCGTTACAATTCAGTTATTAAAGCTTGCTCGCTGTCGAGAGAT
TTTGAATTGTGGACTGATGGTGATGAAACAATTGTTGGAGAAAGAGGGATGAGTTTAAGT
GGCGGACAAAAGGCAAGAATTAGTTTGGCAAGAGCAGTTTATAGAGAAGCTGACATTTAC
TTACTAGATGATCAACTAAGCGCAGTCGATAGTCATGTGCAGAAACATTTGTTTGAAAAT
TGCATCAAAGATTTCTTGAAAGATAAAATTGTCATTCTTGTCACACATCAACTTCAATAT
TTACCTTTTGCTGATCAAATATTTCTCTTCGAAAATGGAAAAATTTTAGCTAAAGGAAAT
TTTGAAACTTTAAAAAATTCGGGTCTTGATTTTACAATAGAAGAGAACAATGACACTGAA
ATTCTTAAAAGACAAATAAGTAAAGAAGTTGAAAAGCCATTGCAAAAAGAAGAGAATAAA
AAAGTTGATAGATCAGAGAAGCGAGCGGAAGGCAGCATTGGATGGAAAATTTATAATGAA
TACTTCCAAGCAACAGGTGGCTATTTAGTCATGTCATTTATCATGGTATTCTTTGTAATT
GCACAATTAATGGCTTCTGCTAGTGATTATTTTGTTTCATACTGGGTATCAAAAGAATCA
CAACGAGATAATGAAAATCAATTAGTCGTCTACGATCGTAATGTCGACATTTACATTTTC
AGTGCATTGACATTTGCAACAGTGTTGCTAACGTTCGGAAGAAGTTTTATGTTTTTCAAT
GTCGCTATGCAGGCAAGTCGTCGATTACATGATGCAATGTTTAATGGAATAAGTCGAGCA
AAAATGTTCTTTTTCAACACAAATCCATCGGGTAGAATTCTTAATAGATTTAGTAAAGAT
TTGAATCAAATTGATGAAATGCTGCCATTTACTTTGATTGATGTTTTTCAAATTTTATTC
TCATTTCTTGGAACAATTGGTGTGTTGGCGGTTGTCAATCAATTCTACCTCATTCCGACA
TTTATTTTATTTTTCATTTTTTATCAAATTCGTCAAGTCTACATAAAAATATCATTGGAT
GTCAAAAGACTAAGCTCAACAACATCATCGCCTGTATTTTCATATCTCAGTGAAACTCTT
ACTGGACTTTCAATTATTCGTGCCTATAAACTTGAAGATCAATTAAAAAGTGAATTTTTT
AATCATTTAGACCTCAATACTTCATCACATTACATTTGGTTAGCAATGACTAGAACTTTT
GCATTTTGGCTTGACATGTGCTGCTTCATTTATATTGCGATTGTAATCATAAGCTTTTTC
TTTACCAATAGTACGAGTGGAAATGTTGGTTTAGCTATTACACAAGCAATGTCACTCACA
AACATGGTACAACTTGGTATGCGACAATCAGCAGTTTTGGAAAATCTCATGACAGCTGTT
GAACGAGTTGTTGAATATCAAACAGTCGACCCAGAGCCTGCTTTCGAGTCAGAAAATGAT
AAGAAACCACCAAAAGAATGGCCTGAGAAAGGTCAAGTGAAATTTGAAAAGTTATCATTA
AGTTATTTCCCCGATATGAAAGAAAAAGTTCTCAAAGAGCTTGAATTTGAAATTAATCCA
CAGGAAAAGATTGGAATTTGTGGTAGAACTGGTGCTGGTAAAAGTTCAATAATCAATGCT
TTATTCAGATTGTCATATTTAGATGGTAAAATAGAAATTGATTTAAGAGACACTGCAAAA
ATGGGATTGCATGATTTGAGATCTAAAATTTCAATTATACCACAAGAACCAGTGCTCTTT
TCAAATTCGATGCGTTACAATCTTGATCCATTTAATGAATATTCAGATGAAAAACTATGG
AGTGCACTTGAAGAGGTTAATTTAAAAAAAATGATTAAAGAAACACCAGCTGGTTTAAAT
ATGGCCATAGCAGAGGGTGGTACAAATTTATCAGTTGGAGAGCGTCAACTTGTTTGCTTA
GCACGTGCCATTTTGCGAGAGAATAAAATTATTGTCATGGATGAAGCAACAGCAAATGTA
GATTTGGAAACTGATGAATTAATTCAGAAAACAATCAGACAAAAATTTAAAAATTGCACT
TTGATAATGATCGCACATCGTTTAAATTCTGTTATGGATAGCGATAGAATTTTAGTTATG
GATGCTGGAAAATGTGTGGAATTTGGATCACCTTATGAACTATTGAATAAAACAGAAGAA
CCGAAATATTTTTATGAAATGCTACAAAATACTGGAAAAGGAAATTTTGAAAGCTTAAAG
AAAATTGCTGAAGAGAATCACTTGATAAAGAAGATGAAATGA

>g6968.t1 Gene=g6968 Length=1273
MESLNSKKQLPPSPREKANLISYITFAWAIPIFLKGRNQTIGDDDLFQPLNEQKASGLAN
KIKDSWNKEEEKCRKDNKKPWLVSVLRRVFGYEVLFQGLFLLFIECGLKILPPIFLNQII
KYHENKDKESEAVMYWSTFGITLCIFFNVIIMHAFNLSNLNLGLKMRIAVSTLIYDKCLQ
LSKSSLANVSLGKIVNLLSSDVGRFDSTAFGFHYLWVGPIQTIFVTYLIYNEIGWSAFGG
VALILLMIPLQLFLGKTTAMLRMKTALRTDKRIKLMNEIIQGIQTIKMYAWEKPMAALIS
QTRGKEIRMIRFVSWIKGITLSLMLFSSRVSIFTSLILFAILGNLLTAQKAFVVTAYYNV
LRQTMVIMYPLAINNVAECRVAIQRIQQLLFITDTNNNEKQNKCPKISSASTYIKMRKVF
AKWNSQSPEMTLTDINIDISSPSLNIVVGRVGSGKSNMIQAILNELPIETGEIDVNGKIS
YASQVPWLFSGSVKQNIVFGLPFDKNRYNSVIKACSLSRDFELWTDGDETIVGERGMSLS
GGQKARISLARAVYREADIYLLDDQLSAVDSHVQKHLFENCIKDFLKDKIVILVTHQLQY
LPFADQIFLFENGKILAKGNFETLKNSGLDFTIEENNDTEILKRQISKEVEKPLQKEENK
KVDRSEKRAEGSIGWKIYNEYFQATGGYLVMSFIMVFFVIAQLMASASDYFVSYWVSKES
QRDNENQLVVYDRNVDIYIFSALTFATVLLTFGRSFMFFNVAMQASRRLHDAMFNGISRA
KMFFFNTNPSGRILNRFSKDLNQIDEMLPFTLIDVFQILFSFLGTIGVLAVVNQFYLIPT
FILFFIFYQIRQVYIKISLDVKRLSSTTSSPVFSYLSETLTGLSIIRAYKLEDQLKSEFF
NHLDLNTSSHYIWLAMTRTFAFWLDMCCFIYIAIVIISFFFTNSTSGNVGLAITQAMSLT
NMVQLGMRQSAVLENLMTAVERVVEYQTVDPEPAFESENDKKPPKEWPEKGQVKFEKLSL
SYFPDMKEKVLKELEFEINPQEKIGICGRTGAGKSSIINALFRLSYLDGKIEIDLRDTAK
MGLHDLRSKISIIPQEPVLFSNSMRYNLDPFNEYSDEKLWSALEEVNLKKMIKETPAGLN
MAIAEGGTNLSVGERQLVCLARAILRENKIIVMDEATANVDLETDELIQKTIRQKFKNCT
LIMIAHRLNSVMDSDRILVMDAGKCVEFGSPYELLNKTEEPKYFYEMLQNTGKGNFESLK
KIAEENHLIKKMK

Protein features from InterProScan

Transcript Database ID Name Start End E.value
45 g6968.t1 CDD cd18579 ABC_6TM_ABCC_D1 98 386 8.51221E-102
47 g6968.t1 CDD cd03250 ABCC_MRP_domain1 414 614 9.16187E-103
44 g6968.t1 CDD cd18580 ABC_6TM_ABCC_D2 693 986 3.08176E-101
46 g6968.t1 CDD cd03244 ABCC_MRP_domain2 1011 1231 5.22219E-123
17 g6968.t1 Gene3D G3DSA:1.20.1560.10 - 88 391 5.7E-14
16 g6968.t1 Gene3D G3DSA:3.40.50.300 - 409 633 5.0E-61
18 g6968.t1 Gene3D G3DSA:1.20.1560.10 - 654 994 2.8E-36
15 g6968.t1 Gene3D G3DSA:3.40.50.300 - 995 1250 3.8E-83
6 g6968.t1 PANTHER PTHR24223:SF334 FI20190P1 6 129 0.0
9 g6968.t1 PANTHER PTHR24223 ATP-BINDING CASSETTE SUB-FAMILY C 6 129 0.0
7 g6968.t1 PANTHER PTHR24223:SF334 FI20190P1 132 638 0.0
10 g6968.t1 PANTHER PTHR24223 ATP-BINDING CASSETTE SUB-FAMILY C 132 638 0.0
5 g6968.t1 PANTHER PTHR24223:SF334 FI20190P1 661 1258 0.0
8 g6968.t1 PANTHER PTHR24223 ATP-BINDING CASSETTE SUB-FAMILY C 661 1258 0.0
2 g6968.t1 Pfam PF00664 ABC transporter transmembrane region 98 365 6.7E-26
3 g6968.t1 Pfam PF00005 ABC transporter 432 564 4.4E-15
1 g6968.t1 Pfam PF00664 ABC transporter transmembrane region 692 958 1.5E-32
4 g6968.t1 Pfam PF00005 ABC transporter 1031 1178 1.1E-27
29 g6968.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 1 19 -
35 g6968.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 20 36 -
19 g6968.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 37 93 -
42 g6968.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 94 115 -
30 g6968.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 116 134 -
43 g6968.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 135 157 -
24 g6968.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 158 208 -
32 g6968.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 209 229 -
31 g6968.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 230 234 -
40 g6968.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 235 254 -
23 g6968.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 255 308 -
38 g6968.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 309 326 -
28 g6968.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 327 331 -
34 g6968.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 332 358 -
22 g6968.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 359 685 -
39 g6968.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 686 705 -
26 g6968.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 706 736 -
36 g6968.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 737 759 -
21 g6968.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 760 806 -
33 g6968.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 807 829 -
27 g6968.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 830 834 -
41 g6968.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 835 854 -
20 g6968.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 855 919 -
37 g6968.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 920 941 -
25 g6968.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 942 1273 -
60 g6968.t1 ProSitePatterns PS00211 ABC transporters family signature. 539 553 -
59 g6968.t1 ProSitePatterns PS00211 ABC transporters family signature. 1150 1164 -
63 g6968.t1 ProSiteProfiles PS50929 ABC transporter integral membrane type-1 fused domain profile. 98 365 29.152
65 g6968.t1 ProSiteProfiles PS50893 ATP-binding cassette, ABC transporter-type domain profile. 414 637 20.575
64 g6968.t1 ProSiteProfiles PS50929 ABC transporter integral membrane type-1 fused domain profile. 693 975 32.729
66 g6968.t1 ProSiteProfiles PS50893 ATP-binding cassette, ABC transporter-type domain profile. 1013 1247 16.774
61 g6968.t1 SMART SM00382 AAA_5 441 614 2.0E-5
62 g6968.t1 SMART SM00382 AAA_5 1040 1224 9.6E-12
12 g6968.t1 SUPERFAMILY SSF90123 ABC transporter transmembrane region 76 386 2.62E-29
14 g6968.t1 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases 407 627 2.4E-50
11 g6968.t1 SUPERFAMILY SSF90123 ABC transporter transmembrane region 690 992 1.44E-51
13 g6968.t1 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases 1003 1245 2.71E-67
55 g6968.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 98 120 -
58 g6968.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 135 157 -
51 g6968.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 210 229 -
53 g6968.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 233 255 -
57 g6968.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 310 332 -
48 g6968.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 336 358 -
54 g6968.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 686 705 -
52 g6968.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 737 759 -
50 g6968.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 810 832 -
56 g6968.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 836 855 -
49 g6968.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 920 942 -

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0055085 transmembrane transport BP
GO:0005524 ATP binding MF
GO:0042626 ATPase-coupled transmembrane transporter activity MF
GO:0016021 integral component of membrane CC
GO:0016887 ATP hydrolysis activity MF

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values