Gene loci information

Transcript annotation

  • This transcript has been annotated as Tyrosine-protein kinase CSK.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_3 g698 g698.t2 isoform g698.t2 5406299 5408788
chr_3 g698 g698.t2 exon g698.t2.exon1 5406299 5408086
chr_3 g698 g698.t2 cds g698.t2.CDS1 5407823 5408086
chr_3 g698 g698.t2 exon g698.t2.exon2 5408147 5408279
chr_3 g698 g698.t2 cds g698.t2.CDS2 5408147 5408279
chr_3 g698 g698.t2 exon g698.t2.exon3 5408495 5408560
chr_3 g698 g698.t2 cds g698.t2.CDS3 5408495 5408560
chr_3 g698 g698.t2 exon g698.t2.exon4 5408627 5408788
chr_3 g698 g698.t2 cds g698.t2.CDS4 5408627 5408709
chr_3 g698 g698.t2 TSS g698.t2 5408806 5408806
chr_3 g698 g698.t2 TTS g698.t2 NA NA

Sequences

>g698.t2 Gene=g698 Length=2149
AACATTAGAGCACGAGAATCTTGTGAAATTCATTGGAATAGTCTTCAATAAACAACATCT
TTATCTTGTCACTGAATATATGAGTAAAGGATCATTAGTCGATTATTTAAGATCACGAGG
TCGTCAACACATTACCAGAAAGGATCAAATCAATTTTGCAAGTGACACATGTTCTGGTAT
GGAATATTTAGAAGCAAAGAAAGTTGTGCATCGTGACTTAGCTGCAAGAAATGTACTTAT
TTCCGAAGAGTGTGTGGCAAAAGTGGCTGATTTTGGTTTAGCGCGTGAGGAGTGTATGAA
CAGCAATGATATAGGAAAACTTCCAATCAAATGGTCAGCACCAGAAGCTCTTAAAAGTGG
CCAATTTTCAAACAAGTCAGACATTTGGAGTTTTGGAATTCTATTATGGGAAATTTATTC
TTTCGGACGTGTTCCTTATCCTCGTATTCCACTTGCAGATGTTACAAAACATGTTGAGGC
CGGTTATAAAATGGAAGCACCTGAAGGTTGTCCCACAGAAATCTACGATATGATGAAAGA
ATGCTGGGACCTTAATCCAAAAAATCGTCCAACATTTAGAGACCTTGCGATAAGATTAAA
ACATTTAAAAACGATAACTACATAAAATTACACTAATTAGATGTGTATTATACATAATTA
TTTAACCTTAGTGTCGAAGTGAGAGTCAACTCTTACTTTTGAAAAAAGAGAAACGAGATT
CAATTCCTTTTTTATTTGTTTTTTGAGTAAGTAAATCTCATAAATGTAATTTTTTGATTT
TAAAATTAATTTATTTTGTTATTATAAAAAGTGCAATGAAAACTATCTATCTAAAATTGA
AAAAAAAAATAATTAGTGTGAGAGATCAAAAATGAAATATTAGTGAACAAGATATAAAAA
ATTTTTCTTGTTATTTAGACATTTTTTTGATCAAAAAAGAGAGAATAGATGAAAAATTCT
TTTTATACTTATGAAACTGGCGATGAATTGAAAATAGAAAAAAAATATCGTCAGTAAAAC
TTACATGGATCACGGTGTCTCCTTAATCAACTACAATATATATTTTTTATTAAATCTGAT
TTTTTGACAAATTTGTTGAGTGTAACAGGACATACATAATATTCATTTTATCTACATACA
TAAAAAGTGAAAGGAAAAACAAAAAAAAAAGATTTAACAAACTATCATCATCGTCAAAAA
TTGTTCGTTTTTGTAGGGAAAATTTTATTGCCACACCAAAAAGTCACCTATACTTGACTA
TCTACATAATATACTAATCAATAAGTATAGTTCTATTAATCGGTATAAAAGCGAAAAAAA
GAGAAATTGAAAATTGCAAATTCACATTCATTCATTTGTAAAATAAAAAAGCAAAAACAA
TAAATTAAAATAAAACTGTAAGTTAATTAACATTTTATTGATGCACTTCATGTGTCTGTA
CTTATTATCCAAAAGAAATTTTTTTTATCATTTTTTCAAATTCTTTCGATTCAACATACT
GTCAGTCTCTTCAGTTTGATTTTGTGTATAATAGTGAACTACGTCATTTGACGGATCGTC
CCAAGGTTGTCTCTTTCCTTGTCCAAAGATATTGTAAAATGTTGCGCATATCGCATAAAC
TGTTGTCGCAATTAAGAACACAATCTAAAAATAGAAAGAAGAAATTTATATGCAAATAAA
ATTGTATTCATTTTATCACACTTACTCTCCACTTGACAATCGAGATTTCATTATTGATTA
TATATCCTGCAGTAATTGGAGCAAGAAGACCTGCCAAATTTGCGGATGCATTTGTCAAGC
TCATTAAAATTCCCGCATAGCGTGGTGAAATATCCAAATGATTAATCTATAAAAATAAAA
CAAAAAGATATTAATGAATTGAAATTTGAAAAACAAAAGAAATTTAATTTTATAAAACTT
ACTTTGAAACCACTATAAATTGCACCATTCAAACTCATTCCAATAGTGAGAAGAACAACT
GTAAGAACCTGTCATTGCATTCAATAAGTTATAAGAAATTTTTTTATATCGTTTTTTACT
TACTCTATTACAGCCTGAATAGCTAACAAACTGTATGCGATATGAATGAAAGAAGAAGAA
ATAAAAAACATTTGTCAATAAATAATTTAAAAATAGTAAAAAACTTTTT

>g698.t2 Gene=g698 Length=181
MSKGSLVDYLRSRGRQHITRKDQINFASDTCSGMEYLEAKKVVHRDLAARNVLISEECVA
KVADFGLAREECMNSNDIGKLPIKWSAPEALKSGQFSNKSDIWSFGILLWEIYSFGRVPY
PRIPLADVTKHVEAGYKMEAPEGCPTEIYDMMKECWDLNPKNRPTFRDLAIRLKHLKTIT
T

Protein features from InterProScan

Transcript Database ID Name Start End E.value
9 g698.t2 Gene3D G3DSA:1.10.510.10 Transferase(Phosphotransferase) domain 1 1 180 4.9E-58
2 g698.t2 PANTHER PTHR24418:SF399 MEGAKARYOCYTE-ASSOCIATED TYROSINE-PROTEIN KINASE 1 175 6.7E-74
3 g698.t2 PANTHER PTHR24418 TYROSINE-PROTEIN KINASE 1 175 6.7E-74
5 g698.t2 PRINTS PR00109 Tyrosine kinase catalytic domain signature 36 54 1.8E-32
6 g698.t2 PRINTS PR00109 Tyrosine kinase catalytic domain signature 81 91 1.8E-32
4 g698.t2 PRINTS PR00109 Tyrosine kinase catalytic domain signature 100 122 1.8E-32
7 g698.t2 PRINTS PR00109 Tyrosine kinase catalytic domain signature 144 166 1.8E-32
1 g698.t2 Pfam PF07714 Protein tyrosine and serine/threonine kinase 1 170 3.7E-66
10 g698.t2 ProSitePatterns PS00109 Tyrosine protein kinases specific active-site signature. 42 54 -
12 g698.t2 ProSiteProfiles PS50011 Protein kinase domain profile. 1 178 28.909
11 g698.t2 SMART SM00219 tyrkin_6 1 173 2.0E-53
8 g698.t2 SUPERFAMILY SSF56112 Protein kinase-like (PK-like) 1 175 2.02E-51

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0004713 protein tyrosine kinase activity MF
GO:0005524 ATP binding MF
GO:0004672 protein kinase activity MF
GO:0006468 protein phosphorylation BP

KEGG

Orthology

This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values