General information for g7007.t12
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Aspartyl/asparaginyl beta-hydroxylase.
Parent gene
- The parent gene g7007 is located on chr_2: 20588347..20592436 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g7007 | g7007.t12 | TSS | g7007.t12 | 20583292 | 20583292 |
| chr_2 | g7007 | g7007.t12 | isoform | g7007.t12 | 20583403 | 20589043 |
| chr_2 | g7007 | g7007.t12 | exon | g7007.t12.exon1 | 20583403 | 20583460 |
| chr_2 | g7007 | g7007.t12 | cds | g7007.t12.CDS1 | 20583403 | 20583460 |
| chr_2 | g7007 | g7007.t12 | exon | g7007.t12.exon2 | 20583963 | 20584157 |
| chr_2 | g7007 | g7007.t12 | cds | g7007.t12.CDS2 | 20583963 | 20584157 |
| chr_2 | g7007 | g7007.t12 | exon | g7007.t12.exon3 | 20584215 | 20584669 |
| chr_2 | g7007 | g7007.t12 | cds | g7007.t12.CDS3 | 20584215 | 20584669 |
| chr_2 | g7007 | g7007.t12 | exon | g7007.t12.exon4 | 20584993 | 20585164 |
| chr_2 | g7007 | g7007.t12 | cds | g7007.t12.CDS4 | 20584993 | 20585164 |
| chr_2 | g7007 | g7007.t12 | exon | g7007.t12.exon5 | 20586862 | 20586935 |
| chr_2 | g7007 | g7007.t12 | cds | g7007.t12.CDS5 | 20586862 | 20586935 |
| chr_2 | g7007 | g7007.t12 | exon | g7007.t12.exon6 | 20587701 | 20587999 |
| chr_2 | g7007 | g7007.t12 | cds | g7007.t12.CDS6 | 20587701 | 20587999 |
| chr_2 | g7007 | g7007.t12 | exon | g7007.t12.exon7 | 20588050 | 20588284 |
| chr_2 | g7007 | g7007.t12 | cds | g7007.t12.CDS7 | 20588050 | 20588284 |
| chr_2 | g7007 | g7007.t12 | exon | g7007.t12.exon8 | 20588345 | 20588918 |
| chr_2 | g7007 | g7007.t12 | cds | g7007.t12.CDS8 | 20588345 | 20588918 |
| chr_2 | g7007 | g7007.t12 | exon | g7007.t12.exon9 | 20588985 | 20589043 |
| chr_2 | g7007 | g7007.t12 | cds | g7007.t12.CDS9 | 20588985 | 20589043 |
| chr_2 | g7007 | g7007.t12 | TTS | g7007.t12 | 20589211 | 20589211 |
Sequences
>g7007.t12 Gene=g7007 Length=2121
ATGTCGGGAGACGTACAAACACGACAAAGGCGAAAGGAGAAGAAAAAACCAAAACGCGAG
GAAGAAATTTCAACAGTTCCTGGAGTTGACACATCAAAATTCAATGAAGCCGAAAAAAAG
ACTGTGCAAATGCACATTCAAGAAAGTGATCATGGTGCAGGCATTTGCGCAAAGATCATT
TTTTTCTCTTTAATGGCAATTTTATTGGGACTTGTGACTCTTATTGTTCTTGAAAATCGC
GGCGGATCTGATGTTGATACACCATTATCAGAATCTCGGTTCTCTGAATATTTAACAGGA
TGGGTAGATGAGAATAGAGAAATAGATGATCATCATGTTGAACCGCATTTTGATATACAT
GATGATGATCCCGACGAAGAGACAACACATGTTTATCAGAAACCGGTTGTACCTGATGAT
GAACCGTTTCCAGAAGAAAGAGATAATTCAAATCCAGATGATGATCATGAAGAATTGAAT
GAAAATTTAAATAATGAATCTGAAAATGATGAAGATGATGTCATATCAGAAAATCAAAAT
GAAATAGATCAACAAGACGAAGAACAAGATGAAGATAACAATGAAAATGAAGTAAATGAT
GAACCATTAAGACAAGAAGAAGAAGAAAATAACGAGAACGAAGCAGCTGATGATGATGAA
AATGAAGTGCCAAATATGTTTGATGACAGTGCACCATTTGATGAGGAGGATGATGATGAT
GAAGACAATTTAAATAGTCAAGAAATTTTTGAAAAAGTAATCGATAATGATGCTGGAGAA
GACTTATTATTGCAAAAATTGGCAGAAGAAAGTGAAAATGCTCAACAGCAGCAATCACAA
GAAAATGATGGAGAAGAAAAAGAAGAAGAATCATCATCACAACTTCCAGAATCAGGTGAT
AGTGGTGCTCAGAGCTATATGGAGGAGTTTCTGAAGCAACAAGCACTTGAAGAGAATCCG
GAAGTAAAAGATCTCTATGAGAAAGCAAAGTCATTAGATGCTACAGCAGAAAGAGAAAAG
AGCAATAAAATATTATTGGAGGCTATTGAAAAATATAAAGAACTTATCAATGTTTATGGT
GACAAAGTGAATGATACAATATTCAAAGAAATTGCTGAAAAATGTATCGAGCGAATGAGA
TTCATGGGAAAACTTAAGCAAACTGTCGACATTCATTATAAATTAATACATCGATTTGTT
GAAAATCCGTCTTACAGGAATCAACTGGCCGTAACCTACTTATTGGGCAATCGTCTTTCA
GCAGCTAAACTTGTACTGCATGAAACGCTCTCTGAGTGGCGAAACAATGGATTTGCATTA
GTTCATTATGGCTATGTATTAAAAAATCTCGATCAAGACTACGAAAATGCAATTTTATAT
TTACGCGAAGGAATAGAAACTAACGATCCTGGTACACAAGATGGTAGATTTTATTACAAT
CTAGGTGATGCTCTCCAAAGACTTGGTAGACAGGAAGAGGCTTTAGAAGTTTATCGAAAA
GGTGCATCAATAGGATTATTTCTATCTGAATACCAAAGATCTCTCTACAATATAGACAGA
CTGAAATCAAAGCCATTTTGGACAAAAGTTGAAACTACTTATAAAGATAATTTAGTAGAA
ATTCAGAAATATTGGCAAATTATAAGAGATGAAGGACTGAAATTATTATCAAATGATGGT
ATATTTATAAATGAACAAGAAAATCTCAAAGACACCGGAGATTGGAAGCAATTTGAATTA
TTTGCACGTGGTGCAGCTACGAAATATTGTCACATGGCCCCAATCACATGTAAAATAATT
AATGGTTTTAAAGCAGCTTCCAGTTGTAAGAGAGGTCAAGTTAAATTCAGTGTGCTTCAT
CCAAATACTCATATACATAGTCATTGTGGCCCAACAAACTGTCGTATAAGAGCGCATTTA
GGACTTCAAGTTCCTGAAAAAACGTTCATAAGAGTGGCTAATGAAACTCGTTCGTGGAAA
GATGGTGAATGGTTGATTTTCGATGATTCTTTCGAACATGAAGTTTGGCATAACGGAACG
AGCATTCGACTTGTTCTTATTGTTGATATGTATCATCCTGATTTGACTGAAGATGAAAAA
CGAAGCTTAAGCCCTATTTAA
>g7007.t12 Gene=g7007 Length=706
MSGDVQTRQRRKEKKKPKREEEISTVPGVDTSKFNEAEKKTVQMHIQESDHGAGICAKII
FFSLMAILLGLVTLIVLENRGGSDVDTPLSESRFSEYLTGWVDENREIDDHHVEPHFDIH
DDDPDEETTHVYQKPVVPDDEPFPEERDNSNPDDDHEELNENLNNESENDEDDVISENQN
EIDQQDEEQDEDNNENEVNDEPLRQEEEENNENEAADDDENEVPNMFDDSAPFDEEDDDD
EDNLNSQEIFEKVIDNDAGEDLLLQKLAEESENAQQQQSQENDGEEKEEESSSQLPESGD
SGAQSYMEEFLKQQALEENPEVKDLYEKAKSLDATAEREKSNKILLEAIEKYKELINVYG
DKVNDTIFKEIAEKCIERMRFMGKLKQTVDIHYKLIHRFVENPSYRNQLAVTYLLGNRLS
AAKLVLHETLSEWRNNGFALVHYGYVLKNLDQDYENAILYLREGIETNDPGTQDGRFYYN
LGDALQRLGRQEEALEVYRKGASIGLFLSEYQRSLYNIDRLKSKPFWTKVETTYKDNLVE
IQKYWQIIRDEGLKLLSNDGIFINEQENLKDTGDWKQFELFARGAATKYCHMAPITCKII
NGFKAASSCKRGQVKFSVLHPNTHIHSHCGPTNCRIRAHLGLQVPEKTFIRVANETRSWK
DGEWLIFDDSFEHEVWHNGTSIRLVLIVDMYHPDLTEDEKRSLSPI
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 11 | g7007.t12 | Coils | Coil | Coil | 153 | 195 | - |
| 12 | g7007.t12 | Coils | Coil | Coil | 267 | 288 | - |
| 10 | g7007.t12 | Coils | Coil | Coil | 322 | 342 | - |
| 8 | g7007.t12 | Gene3D | G3DSA:1.25.40.10 | - | 241 | 506 | 1.4E-12 |
| 9 | g7007.t12 | Gene3D | G3DSA:2.60.120.330 | - | 514 | 705 | 1.3E-64 |
| 17 | g7007.t12 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1 | 26 | - |
| 20 | g7007.t12 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1 | 29 | - |
| 18 | g7007.t12 | MobiDBLite | mobidb-lite | consensus disorder prediction | 135 | 158 | - |
| 22 | g7007.t12 | MobiDBLite | mobidb-lite | consensus disorder prediction | 135 | 303 | - |
| 21 | g7007.t12 | MobiDBLite | mobidb-lite | consensus disorder prediction | 159 | 245 | - |
| 19 | g7007.t12 | MobiDBLite | mobidb-lite | consensus disorder prediction | 253 | 267 | - |
| 3 | g7007.t12 | PANTHER | PTHR12366 | ASPARTYL/ASPARAGINYL BETA-HYDROXYLASE | 1 | 293 | 1.2E-193 |
| 5 | g7007.t12 | PANTHER | PTHR12366:SF29 | ASPARTYL/ASPARAGINYL BETA-HYDROXYLASE | 1 | 293 | 1.2E-193 |
| 2 | g7007.t12 | PANTHER | PTHR12366 | ASPARTYL/ASPARAGINYL BETA-HYDROXYLASE | 320 | 706 | 1.2E-193 |
| 4 | g7007.t12 | PANTHER | PTHR12366:SF29 | ASPARTYL/ASPARAGINYL BETA-HYDROXYLASE | 320 | 706 | 1.2E-193 |
| 1 | g7007.t12 | Pfam | PF05118 | Aspartyl/Asparaginyl beta-hydroxylase | 543 | 693 | 5.2E-51 |
| 13 | g7007.t12 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 1 | 54 | - |
| 15 | g7007.t12 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 55 | 77 | - |
| 14 | g7007.t12 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 78 | 706 | - |
| 23 | g7007.t12 | ProSiteProfiles | PS50293 | TPR repeat region circular profile. | 403 | 508 | 10.002 |
| 6 | g7007.t12 | SUPERFAMILY | SSF48452 | TPR-like | 382 | 505 | 1.33E-11 |
| 7 | g7007.t12 | SUPERFAMILY | SSF51197 | Clavaminate synthase-like | 572 | 694 | 9.34E-17 |
| 16 | g7007.t12 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 54 | 76 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0018193 | peptidyl-amino acid modification | BP |
| GO:0005515 | protein binding | MF |
| GO:0042264 | peptidyl-aspartic acid hydroxylation | BP |
| GO:0004597 | NA | NA |
KEGG
Orthology
- This transcript has been annotated with K00476 (aspartate beta-hydroxylase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
