General information for g7151.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as High affinity cAMP-specific and IBMX-insensitive 3’,5’-cyclic phosphodiesterase 8.
Parent gene
- The parent gene g7151 is located on chr_2: 21519292..21525269 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g7151 | g7151.t1 | isoform | g7151.t1 | 21519292 | 21525269 |
| chr_2 | g7151 | g7151.t1 | exon | g7151.t1.exon1 | 21519292 | 21519532 |
| chr_2 | g7151 | g7151.t1 | cds | g7151.t1.CDS1 | 21519292 | 21519532 |
| chr_2 | g7151 | g7151.t1 | exon | g7151.t1.exon2 | 21519650 | 21519727 |
| chr_2 | g7151 | g7151.t1 | cds | g7151.t1.CDS2 | 21519650 | 21519727 |
| chr_2 | g7151 | g7151.t1 | exon | g7151.t1.exon3 | 21519901 | 21520010 |
| chr_2 | g7151 | g7151.t1 | cds | g7151.t1.CDS3 | 21519901 | 21520010 |
| chr_2 | g7151 | g7151.t1 | exon | g7151.t1.exon4 | 21520082 | 21520465 |
| chr_2 | g7151 | g7151.t1 | cds | g7151.t1.CDS4 | 21520082 | 21520465 |
| chr_2 | g7151 | g7151.t1 | exon | g7151.t1.exon5 | 21520538 | 21520891 |
| chr_2 | g7151 | g7151.t1 | cds | g7151.t1.CDS5 | 21520538 | 21520891 |
| chr_2 | g7151 | g7151.t1 | exon | g7151.t1.exon6 | 21520955 | 21521506 |
| chr_2 | g7151 | g7151.t1 | cds | g7151.t1.CDS6 | 21520955 | 21521506 |
| chr_2 | g7151 | g7151.t1 | exon | g7151.t1.exon7 | 21521617 | 21521826 |
| chr_2 | g7151 | g7151.t1 | cds | g7151.t1.CDS7 | 21521617 | 21521826 |
| chr_2 | g7151 | g7151.t1 | exon | g7151.t1.exon8 | 21521918 | 21521975 |
| chr_2 | g7151 | g7151.t1 | cds | g7151.t1.CDS8 | 21521918 | 21521975 |
| chr_2 | g7151 | g7151.t1 | exon | g7151.t1.exon9 | 21522606 | 21522665 |
| chr_2 | g7151 | g7151.t1 | cds | g7151.t1.CDS9 | 21522606 | 21522665 |
| chr_2 | g7151 | g7151.t1 | exon | g7151.t1.exon10 | 21522735 | 21522985 |
| chr_2 | g7151 | g7151.t1 | cds | g7151.t1.CDS10 | 21522735 | 21522985 |
| chr_2 | g7151 | g7151.t1 | exon | g7151.t1.exon11 | 21524677 | 21524786 |
| chr_2 | g7151 | g7151.t1 | cds | g7151.t1.CDS11 | 21524677 | 21524786 |
| chr_2 | g7151 | g7151.t1 | exon | g7151.t1.exon12 | 21524888 | 21525269 |
| chr_2 | g7151 | g7151.t1 | cds | g7151.t1.CDS12 | 21524888 | 21525269 |
| chr_2 | g7151 | g7151.t1 | TSS | g7151.t1 | NA | NA |
| chr_2 | g7151 | g7151.t1 | TTS | g7151.t1 | NA | NA |
Sequences
>g7151.t1 Gene=g7151 Length=2790
ATGGTTGATTCATGCTTTAAATTATTTCGCAAGACAAAATGTCTTAATGGAAAGTCTTCA
AAACTACAATGTGATAGTTTTGAATCGCTCTATTTGAATGAAAATAACAATAAAACGTCT
TCTTCAGTTCCTGTTAGCAAGAAATATAATGATAATATCATTACCGATATTGAAACGTAT
CATCATAACGATATGATTGAGGATGGGGTGATTTTGAGACGTCATAATCGAAAATATCTC
ACTTCAGTTTCGACAGTTAGCAATGACGCGCTGTCTAGTGATGACGACGATAATGAGACA
CTTGATATTTTATATCCTTTACCGCATGTGAACACACACGAACGGTCACTTGTCGATGAA
ACCAAATACTGTGATAAGAATGATAAAAATCCTCTTGCTACTCAAGATAACAATAATGAG
AACCGTTTATTACGAAATGAATCCGGTTCATACTTGCTGAAAAAGCTCTTTAAGCAAAAA
TTAAAACGACAGAAACTGCATGATGGTAAATATCCATATCTCATTCCGCCTAATCCTTCT
GTGCGTGCCCTTATTGTCTTTGGAAAGGATGATCAAGTCAGTGATGCCCTTCAAAAATCC
TGCGAGCGTTTAAATATTGAAATAACACGCTCGAAAAGTATAGATCTTGCGCTAGAGCTC
TTTCAAAGTCCTGTCAATGGTGGTCATCATCTTGTAATAGTTGATGGACGATGTAAAAAT
GTTGATATTGAGTCATTTGGAAGATCATTGAGAAGCTCAAAAGGAAGTCAATATACGATA
ATGGTGTGCGTGGTTAAAAAGAGTGTTTTCGAGAAGGACGATACGTCGATTCTCTCGCTT
TTAGATGTAGGATATAATAGATGTATAATTGAATCTCCACATGTATCAATATTAAGCTCA
GAGCTTCGGCAAATACAACATTCGCTCATTAGACCACAAAATGTTATCGCCACACAACAA
GCTCTTTATGCGGCCCTTCATCGATCGAAGGATACAGTTCTTATAACAGACGATGCTTTA
AGGATACAGTATATGAATAAACAAACTGAACGAATTTTGGGCATGAAAATTGATGAAATT
GTGGGACGTCCATTACAAGATCTTATCAATTCAGATGTATCGCTATTATTGAGTCAAACA
AATAGACTTAGAGAGTTTGATGGTACACTATCATTCAATCGTAAGACACAAGATCCAATT
GTGTTTCATGTTCGTGCTTACCCTGTAGCTTGCATTGGAAAGTCCACAACTCATTTAATT
TTAAGTATAAGTGGCATACAAGGTGCTGGTCATGAGATTGGATTACCATCAATTCCTCAA
GCTAAAGAACCACGTGGTTCACTACATTCAATACGTCGCGGTAGTTTTGACATTCGTTCA
ATTGCATCTGATGGATTGAGACGGACAAGTTTAGCTAAATTGAGTTCACTACCACTTGAG
GCTCCAATTACTAAAGTGCTCACATTACTTGCACAAGTTCAAGAAAATTGTTCAGCAGAT
GAAGCTCGATTATTGGATCGCGTTATGGACTTTTTAAAACGCGAGGGATTATATAGTCCA
CAAATAAAAGAGATCCGCCCCGAAGATCCTGTGGCGACAGATCTTATAGGAGCTTTACTA
ACACAGGGCCCTACAAATGTCGTGTCATCACGTCGAAGCTCAAATGAATCGATAATCCGT
TCTGGTAGTCGACAATCAAGCACAAGTGTGTCGGTGGCAAAGATGAAAATTCCAACACAA
GTCTCAGAACTACTTGAATGTGCGCTTGACTGGGATTTTGAAATTTTCCGCCTGGAAGAA
TTGACTGATAAGCATCCGCTTGTGTATTTAGGCTCAGAATTGTTTCGACGCTTTGATGTA
TACAACACATTTAATTGCGACGAAATGACTTTCAGATCATGGCTTATTGTTATGGAATCG
CATTATCACAATGCAAATACTTATCATAACTCAACTCATGCAGCTGACGTTATGCAGGCA
ACAGCGTGCTATTTACAACAATTGGCGAATCGTGACTTAAAAATCATGGATCGATTAGAC
GAAGCAACAGCATTAATAGCGTCCGCTGCACATGACGTCGACCATCCGGGTCGAAGTTCT
GCCTTTCTCTGCAATTCTGATAATTCGCTCGCTCTGCTTTATAATGACATTTGTGTACTT
GAATCGCATCATGCAGCTACAACCTTCCGTCTCACGCTCTCCGACGAAAAAATTAATATT
TTCAAGAATTTAGACCGTGATATGTATAAATTAGCACGTTCAATTATAATCGATATGATT
CTTGCAACAGAAATGACGAGACATTTTGAGCACTTAGCTAAGTTTGTAAGTGTTTTTGGA
AACGATGCAGAATCGAGAGAGCTTCCAAATGATGAAGACAATCAAATGCTGATTCGTCGA
ATGCTCATTAAATGTTCTGATGTCAGTAATCCTACACGTCCATTAAAATTTTGCGTCGAA
TGGGCAAGAAGAATTGCTGAGGAATATTTTATACAAACTGACGAAGAGAAGCGAAAAGGC
ATGCCTATTGTGATGCCTATGTTTGACAGAGCGACATGTTCTATTTCTAAAAGTCAAATC
GGCTTTATAGAATTCATTATTCAAGATATGATGAATGCGTGGGATGGATTTATCGATATG
CCTGAGCTCGTTCAATACATGCAATATAATTATACTCAATGGAAGCTTTTTGAGGAGCAA
GGTATCAATACATTGAACGATATTAAACGCAAACAAGTGTCGATTACAAACGCGAGTCTT
TCAAATATGAAACTCGATGAGATGATGTGA
>g7151.t1 Gene=g7151 Length=929
MVDSCFKLFRKTKCLNGKSSKLQCDSFESLYLNENNNKTSSSVPVSKKYNDNIITDIETY
HHNDMIEDGVILRRHNRKYLTSVSTVSNDALSSDDDDNETLDILYPLPHVNTHERSLVDE
TKYCDKNDKNPLATQDNNNENRLLRNESGSYLLKKLFKQKLKRQKLHDGKYPYLIPPNPS
VRALIVFGKDDQVSDALQKSCERLNIEITRSKSIDLALELFQSPVNGGHHLVIVDGRCKN
VDIESFGRSLRSSKGSQYTIMVCVVKKSVFEKDDTSILSLLDVGYNRCIIESPHVSILSS
ELRQIQHSLIRPQNVIATQQALYAALHRSKDTVLITDDALRIQYMNKQTERILGMKIDEI
VGRPLQDLINSDVSLLLSQTNRLREFDGTLSFNRKTQDPIVFHVRAYPVACIGKSTTHLI
LSISGIQGAGHEIGLPSIPQAKEPRGSLHSIRRGSFDIRSIASDGLRRTSLAKLSSLPLE
APITKVLTLLAQVQENCSADEARLLDRVMDFLKREGLYSPQIKEIRPEDPVATDLIGALL
TQGPTNVVSSRRSSNESIIRSGSRQSSTSVSVAKMKIPTQVSELLECALDWDFEIFRLEE
LTDKHPLVYLGSELFRRFDVYNTFNCDEMTFRSWLIVMESHYHNANTYHNSTHAADVMQA
TACYLQQLANRDLKIMDRLDEATALIASAAHDVDHPGRSSAFLCNSDNSLALLYNDICVL
ESHHAATTFRLTLSDEKINIFKNLDRDMYKLARSIIIDMILATEMTRHFEHLAKFVSVFG
NDAESRELPNDEDNQMLIRRMLIKCSDVSNPTRPLKFCVEWARRIAEEYFIQTDEEKRKG
MPIVMPMFDRATCSISKSQIGFIEFIIQDMMNAWDGFIDMPELVQYMQYNYTQWKLFEEQ
GINTLNDIKRKQVSITNASLSNMKLDEMM
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 15 | g7151.t1 | CDD | cd00130 | PAS | 333 | 426 | 0.0000256 |
| 14 | g7151.t1 | CDD | cd00077 | HDc | 648 | 830 | 0.0000000 |
| 13 | g7151.t1 | Gene3D | G3DSA:3.30.450.20 | - | 313 | 427 | 0.0000000 |
| 12 | g7151.t1 | Gene3D | G3DSA:1.10.1300.10 | Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b | 575 | 899 | 0.0000000 |
| 3 | g7151.t1 | PANTHER | PTHR11347 | CYCLIC NUCLEOTIDE PHOSPHODIESTERASE | 180 | 903 | 0.0000000 |
| 4 | g7151.t1 | PANTHER | PTHR11347:SF85 | HIGH AFFINITY CAMP-SPECIFIC AND IBMX-INSENSITIVE 3’,5’-CYCLIC PHOSPHODIESTERASE 8A | 180 | 903 | 0.0000000 |
| 8 | g7151.t1 | PRINTS | PR00387 | 3’5’-cyclic nucleotide phosphodiesterase signature | 644 | 657 | 0.0000000 |
| 9 | g7151.t1 | PRINTS | PR00387 | 3’5’-cyclic nucleotide phosphodiesterase signature | 691 | 706 | 0.0000000 |
| 6 | g7151.t1 | PRINTS | PR00387 | 3’5’-cyclic nucleotide phosphodiesterase signature | 718 | 734 | 0.0000000 |
| 5 | g7151.t1 | PRINTS | PR00387 | 3’5’-cyclic nucleotide phosphodiesterase signature | 803 | 816 | 0.0000000 |
| 7 | g7151.t1 | PRINTS | PR00387 | 3’5’-cyclic nucleotide phosphodiesterase signature | 820 | 836 | 0.0000000 |
| 2 | g7151.t1 | Pfam | PF13426 | PAS domain | 332 | 419 | 0.0000000 |
| 1 | g7151.t1 | Pfam | PF00233 | 3’5’-cyclic nucleotide phosphodiesterase | 648 | 886 | 0.0000000 |
| 19 | g7151.t1 | ProSiteProfiles | PS50112 | PAS repeat profile. | 318 | 372 | 12.3250000 |
| 18 | g7151.t1 | ProSiteProfiles | PS51845 | 3’5’-cyclic nucleotide phosphodiesterase domain profile. | 573 | 901 | 113.6460000 |
| 16 | g7151.t1 | SMART | SM00091 | pas_2 | 320 | 385 | 0.0002600 |
| 11 | g7151.t1 | SUPERFAMILY | SSF55785 | PYP-like sensor domain (PAS domain) | 323 | 410 | 0.0000000 |
| 10 | g7151.t1 | SUPERFAMILY | SSF109604 | HD-domain/PDEase-like | 577 | 913 | 0.0000000 |
| 17 | g7151.t1 | TIGRFAM | TIGR00229 | sensory_box: PAS domain S-box protein | 320 | 372 | 0.0000014 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0008081 | phosphoric diester hydrolase activity | MF |
| GO:0007165 | signal transduction | BP |
| GO:0004114 | 3’,5’-cyclic-nucleotide phosphodiesterase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K18437 (high affinity cAMP-specific and IBMX-insensitive 3’,5’-cyclic phosphodiesterase 8)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
