General information for g7506.t2
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Putative Zinc metalloproteinase nas-4.
Parent gene
- The parent gene g7506 is located on chr_2: 24105093..24106212 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g7506 | g7506.t2 | TTS | g7506.t2 | 24105001 | 24105001 |
| chr_2 | g7506 | g7506.t2 | isoform | g7506.t2 | 24105093 | 24106212 |
| chr_2 | g7506 | g7506.t2 | exon | g7506.t2.exon1 | 24105093 | 24105617 |
| chr_2 | g7506 | g7506.t2 | cds | g7506.t2.CDS1 | 24105093 | 24105617 |
| chr_2 | g7506 | g7506.t2 | exon | g7506.t2.exon2 | 24105675 | 24105787 |
| chr_2 | g7506 | g7506.t2 | cds | g7506.t2.CDS2 | 24105675 | 24105787 |
| chr_2 | g7506 | g7506.t2 | exon | g7506.t2.exon3 | 24105846 | 24106212 |
| chr_2 | g7506 | g7506.t2 | cds | g7506.t2.CDS3 | 24105846 | 24105975 |
| chr_2 | g7506 | g7506.t2 | TSS | g7506.t2 | 24106252 | 24106252 |
Sequences
>g7506.t2 Gene=g7506 Length=1005
ATGATTAAAATCATTTGTATTTGCACTTTTGCCATTTTGGCATTAAACTCTGTTCGTTCA
CTTCCAATGCCTGATTATGTTGTACCCAACACACCAGAAAATCGTAAGTTCGGAAGAGAG
AAAAAATATGATTGAGAACTTTAAAGACATTTTTCACATTGCAAAATAGTCGAGAGGTTA
AAGAATCTCGGTCCAGATGATCTAGCTGAAGAGTTAAGTGGTCAATTTGAAGGCGATATG
GTTATGTCACCAAGTGAAATTGCACAGCTCATTGGTGGTAATAAAAATGGTAAAACTGGA
CTTATTGCTGAAAGATTTCGATGGCCTGATAATATTATCCCTTACACAATTAATGAAGAA
GACTTTTCTTCAGCACAAATTCATTATATTCATCTTGCTGCAGAGAGACTTATGGAAGTG
ACTTGTTTGAAATTTGTTCCATATAGAGAAGGCGTTCATACCAACTATATTTGGGTCACT
GGAGAAAATAGTGGTTGCTGGTCGTATGTAGGAATGCGTAATGGTCGTCAACAATTGAAT
TTGACTCCTAACAATCCTGAAGTCGGATGTTTCCGTTTGTATACAATTGTTCATGAATTT
ATGCATGCATTAGGATTTTATCATATGCAAAGTGCAACCGAGAGAGATGAATATGTGAGA
ATCGTTTGGGAAAATATTCAAGCTGGAACACAAAACAATTTCAATACATATGATGCACAG
ACAATTACTCAATTTGGCATCGAGTATGATTATGGTTCAGTAATGCACTATTCAAGAACT
GCATTTAGTATAAATGGTTCTGACACAATCGTTGCACTTAAAGATTTGGGCGATAGCATT
ATGGGTCAAAGAGTCAGAATGAGTGACAAGGATATTGCAAGAATTAACGCTATGTATTGT
CCACTATCACCAAGACCACCACCACCACAATCACTTACAGAATTCTTCTACCGATTAAAT
AATGGAATGAACAAACTTTTTTATAACATCTTTTCTCGCTTCTAA
>g7506.t2 Gene=g7506 Length=255
MVMSPSEIAQLIGGNKNGKTGLIAERFRWPDNIIPYTINEEDFSSAQIHYIHLAAERLME
VTCLKFVPYREGVHTNYIWVTGENSGCWSYVGMRNGRQQLNLTPNNPEVGCFRLYTIVHE
FMHALGFYHMQSATERDEYVRIVWENIQAGTQNNFNTYDAQTITQFGIEYDYGSVMHYSR
TAFSINGSDTIVALKDLGDSIMGQRVRMSDKDIARINAMYCPLSPRPPPPQSLTEFFYRL
NNGMNKLFYNIFSRF
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 11 | g7506.t2 | CDD | cd04280 | ZnMc_astacin_like | 31 | 220 | 0.000 |
| 10 | g7506.t2 | Gene3D | G3DSA:3.40.390.10 | Collagenase (Catalytic Domain) | 6 | 223 | 0.000 |
| 2 | g7506.t2 | PANTHER | PTHR10127:SF837 | METALLOENDOPEPTIDASE | 25 | 224 | 0.000 |
| 3 | g7506.t2 | PANTHER | PTHR10127 | DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING | 25 | 224 | 0.000 |
| 7 | g7506.t2 | PRINTS | PR00480 | Astacin family signature | 51 | 69 | 0.000 |
| 6 | g7506.t2 | PRINTS | PR00480 | Astacin family signature | 111 | 129 | 0.000 |
| 4 | g7506.t2 | PRINTS | PR00480 | Astacin family signature | 130 | 147 | 0.000 |
| 5 | g7506.t2 | PRINTS | PR00480 | Astacin family signature | 169 | 184 | 0.000 |
| 8 | g7506.t2 | PRINTS | PR00480 | Astacin family signature | 208 | 221 | 0.000 |
| 1 | g7506.t2 | Pfam | PF01400 | Astacin (Peptidase family M12A) | 28 | 222 | 0.000 |
| 13 | g7506.t2 | ProSiteProfiles | PS51864 | Astacin-like domain profile. | 17 | 222 | 69.149 |
| 12 | g7506.t2 | SMART | SM00235 | col_5 | 25 | 174 | 0.000 |
| 9 | g7506.t2 | SUPERFAMILY | SSF55486 | Metalloproteases (zincins), catalytic domain | 26 | 221 | 0.000 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0008237 | metallopeptidase activity | MF |
| GO:0006508 | proteolysis | BP |
| GO:0004222 | metalloendopeptidase activity | MF |
| GO:0008270 | zinc ion binding | MF |
KEGG
Orthology
- This transcript has been annotated with K08606 (meprin B)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed