General information for g7512.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Sodium/hydrogen exchanger 7.
Parent gene
- The parent gene g7512 is located on chr_2: 24145511..24146415 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g7512 | g7512.t1 | TSS | g7512.t1 | 24141805 | 24141805 |
| chr_2 | g7512 | g7512.t1 | isoform | g7512.t1 | 24141868 | 24145835 |
| chr_2 | g7512 | g7512.t1 | exon | g7512.t1.exon1 | 24141868 | 24141997 |
| chr_2 | g7512 | g7512.t1 | cds | g7512.t1.CDS1 | 24141868 | 24141997 |
| chr_2 | g7512 | g7512.t1 | exon | g7512.t1.exon2 | 24142112 | 24142204 |
| chr_2 | g7512 | g7512.t1 | cds | g7512.t1.CDS2 | 24142112 | 24142204 |
| chr_2 | g7512 | g7512.t1 | exon | g7512.t1.exon3 | 24142889 | 24143763 |
| chr_2 | g7512 | g7512.t1 | cds | g7512.t1.CDS3 | 24142889 | 24143763 |
| chr_2 | g7512 | g7512.t1 | exon | g7512.t1.exon4 | 24143823 | 24143994 |
| chr_2 | g7512 | g7512.t1 | cds | g7512.t1.CDS4 | 24143823 | 24143994 |
| chr_2 | g7512 | g7512.t1 | exon | g7512.t1.exon5 | 24144053 | 24144363 |
| chr_2 | g7512 | g7512.t1 | cds | g7512.t1.CDS5 | 24144053 | 24144363 |
| chr_2 | g7512 | g7512.t1 | exon | g7512.t1.exon6 | 24144518 | 24144550 |
| chr_2 | g7512 | g7512.t1 | cds | g7512.t1.CDS6 | 24144518 | 24144550 |
| chr_2 | g7512 | g7512.t1 | exon | g7512.t1.exon7 | 24144756 | 24144874 |
| chr_2 | g7512 | g7512.t1 | cds | g7512.t1.CDS7 | 24144756 | 24144874 |
| chr_2 | g7512 | g7512.t1 | exon | g7512.t1.exon8 | 24144932 | 24145139 |
| chr_2 | g7512 | g7512.t1 | cds | g7512.t1.CDS8 | 24144932 | 24145139 |
| chr_2 | g7512 | g7512.t1 | exon | g7512.t1.exon9 | 24145797 | 24145835 |
| chr_2 | g7512 | g7512.t1 | cds | g7512.t1.CDS9 | 24145797 | 24145835 |
| chr_2 | g7512 | g7512.t1 | TTS | g7512.t1 | 24146047 | 24146047 |
Sequences
>g7512.t1 Gene=g7512 Length=1980
ATGAAAACTCTAATAATTGTGACTTTATTAGGATTAATAAATGACATAAGAGCAGACAAT
TTTGATATTTTAATAGATACAAAAGCAAACTCTATTCATCGACTGGATTCTTTGAATTTA
TTGATTTATTGTTCACTATTGGCACTCACTGTTCTGACAATATGGGTTTTTAAGTACAGA
AGAGTATCGTGGTTGAATGAGACAGGCTTAGCAGTTATTTATGGTCTCATTGTAGGAGCG
ATAATTCGTTTTGCTGGAAACAGTTCACCAACAACACATTTACGTGTTGAAGCTGATAAG
TCAACAAAATACAATGACACTCTACCACCTGATGCTTTGTGGTTAAAATTTCCAGGAAAT
TTAAATATTTCTGGCCCAACACAAAATCAAACTTATGCATACTCATTTCGTGGTCAACTT
TATGGCAATTTAAATGAAATCGATTTGAAAGCAACTTTCGATCCAGAAATTTTTTTCAAC
ATTATTCTACCGCCAATTATTTTCTATGCTGGTTATAGCTTGAAGCGAAAATATTTCTTT
AGAAATTTGGGAACAATTCTAACTTTTGCTATAATTGGAACAACTCTTTCGGCATTGCTG
ATTGGTGCACTTATGTATTGCTTTGTACAACTGATTTCAATTCGCGAAAGCTTTACCTTC
TTAGACACACTTTATTTTGGTGCACTCATAAGTCCAACCGATCCGCTCACAATTTTGGCA
ATATTTAGTGAGAAAAATGTTGATGTTAATCTATACGCTCTGGTTTTTGGTGAGAGCGTG
CTCAATGATGCCGTTGCAATAGTTTTGAGTGGAGCTATTCAAAATTATGGCGAGCATTAT
TCAAAAACAGGAGATTTTGAGACACATGCGTTTATACATGCTCTTAAAGACTTCTTTTTT
ATATTTTTCTTCTCACTGGTTGTCGGCACTTCAATGGGCTGTCTCACATCGCTTATGACA
AAGTTTACAAAAATTAGAGAATTCCCGCTACTTGAATCTGCATTATTTGTGCTCATGTCG
TACAGTACTTTCCTCATTGCTGAGGTTTTTGAATTGACTGGAGTTGTAGCTGTGCTATTT
TGTGGAATTTGTCAAGCACATTATACATTCAATAATTTATCAGAAGAGTCAAGGACAAGA
ACAAAGCAGTTGTTTGAGCTTTTGAACTTTTTAGCAGAAAATTTTATCTTTTCATATATT
GGTGTGTCGATGTTTTCATTTCCTCGACATCATTTTGATGCTCTTTTCATCATTGGTGGA
TTTTTATGTGCAATGATTGGTAGAGCAGTAAATGTTTATCCTTTAGCATGGGTAATTAAC
TTGGGACGAAAGCCTAAAATGCCTTGGAACTTTCAACATATGTTGTTCTTTGCTGGTCTT
CGTGGTGCAATGTCTTTTGCTCTTGCGATTCGCAACACTGTCTCAGAAGCACGTCAAACT
ATGCTCACATGTACATCATTAATTGTAATTGTGTCAGTACTTTTTCAAGGTGGTGCAGCA
AATTTCGTCCTACAATTTCTAAAAATTCCAATTGGAGTTGAAGATGAAACAGAGCAGCTA
ACTTATCAGTCTGTCAAAAGTGTGTACTGCTCAATGGATAACAATACTGTTGCGGATTTG
GAAAGTCCTGATCCCCATTCACCAAGTGGTAGTGATCAACCTCAAACAAGTACATCAACT
AGAAAGAATGAAAAAGCATTGTTGGCTAGAATATGGGGAAATTTCGATTCAAGATATATG
AAGCCATTTTTAACAAATTCACGTCCAACACTGTTAGAAACATTACCAGAATTTTTGACA
CCACTTGCACGAGTGCTTACTACAACCGAACAATTAAATCAAAGTGGTCGTACTAGGAAA
CTCGATTCAGATTCAGATTTATGCATAGATGAAACAAATGGCGGTGGTGGTGGAAGTACG
AGAAGAAATTCAATAAGTCGAGTTCTACCACGAAGTCCTCATTCATCAGCTATTATTTGA
>g7512.t1 Gene=g7512 Length=659
MKTLIIVTLLGLINDIRADNFDILIDTKANSIHRLDSLNLLIYCSLLALTVLTIWVFKYR
RVSWLNETGLAVIYGLIVGAIIRFAGNSSPTTHLRVEADKSTKYNDTLPPDALWLKFPGN
LNISGPTQNQTYAYSFRGQLYGNLNEIDLKATFDPEIFFNIILPPIIFYAGYSLKRKYFF
RNLGTILTFAIIGTTLSALLIGALMYCFVQLISIRESFTFLDTLYFGALISPTDPLTILA
IFSEKNVDVNLYALVFGESVLNDAVAIVLSGAIQNYGEHYSKTGDFETHAFIHALKDFFF
IFFFSLVVGTSMGCLTSLMTKFTKIREFPLLESALFVLMSYSTFLIAEVFELTGVVAVLF
CGICQAHYTFNNLSEESRTRTKQLFELLNFLAENFIFSYIGVSMFSFPRHHFDALFIIGG
FLCAMIGRAVNVYPLAWVINLGRKPKMPWNFQHMLFFAGLRGAMSFALAIRNTVSEARQT
MLTCTSLIVIVSVLFQGGAANFVLQFLKIPIGVEDETEQLTYQSVKSVYCSMDNNTVADL
ESPDPHSPSGSDQPQTSTSTRKNEKALLARIWGNFDSRYMKPFLTNSRPTLLETLPEFLT
PLARVLTTTEQLNQSGRTRKLDSDSDLCIDETNGGGGGSTRRNSISRVLPRSPHSSAII
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 52 | g7512.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 540 | 563 | - |
| 53 | g7512.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 612 | 659 | - |
| 54 | g7512.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 636 | 659 | - |
| 2 | g7512.t1 | PANTHER | PTHR10110 | SODIUM/HYDROGEN EXCHANGER | 20 | 631 | 5.6E-193 |
| 3 | g7512.t1 | PANTHER | PTHR10110:SF94 | SODIUM/HYDROGEN EXCHANGER 6 | 20 | 631 | 5.6E-193 |
| 6 | g7512.t1 | PRINTS | PR01088 | Na+/H+ exchanger isoform 6 (NHE6) signature | 30 | 54 | 9.7E-15 |
| 5 | g7512.t1 | PRINTS | PR01088 | Na+/H+ exchanger isoform 6 (NHE6) signature | 55 | 73 | 9.7E-15 |
| 10 | g7512.t1 | PRINTS | PR01084 | Na+/H+ exchanger signature | 157 | 168 | 7.6E-18 |
| 11 | g7512.t1 | PRINTS | PR01084 | Na+/H+ exchanger signature | 171 | 185 | 7.6E-18 |
| 8 | g7512.t1 | PRINTS | PR01084 | Na+/H+ exchanger signature | 186 | 194 | 7.6E-18 |
| 9 | g7512.t1 | PRINTS | PR01084 | Na+/H+ exchanger signature | 227 | 237 | 7.6E-18 |
| 4 | g7512.t1 | PRINTS | PR01088 | Na+/H+ exchanger isoform 6 (NHE6) signature | 500 | 526 | 9.7E-15 |
| 7 | g7512.t1 | PRINTS | PR01088 | Na+/H+ exchanger isoform 6 (NHE6) signature | 609 | 630 | 9.7E-15 |
| 1 | g7512.t1 | Pfam | PF00999 | Sodium/hydrogen exchanger family | 46 | 504 | 7.1E-73 |
| 26 | g7512.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 18 | - |
| 27 | g7512.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 2 | - |
| 28 | g7512.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 3 | 13 | - |
| 41 | g7512.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 14 | 18 | - |
| 25 | g7512.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 19 | 36 | - |
| 32 | g7512.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 37 | 57 | - |
| 18 | g7512.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 58 | 68 | - |
| 30 | g7512.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 69 | 86 | - |
| 19 | g7512.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 87 | 156 | - |
| 35 | g7512.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 157 | 174 | - |
| 17 | g7512.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 175 | 185 | - |
| 39 | g7512.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 186 | 212 | - |
| 24 | g7512.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 213 | 223 | - |
| 40 | g7512.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 224 | 242 | - |
| 16 | g7512.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 243 | 248 | - |
| 36 | g7512.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 249 | 273 | - |
| 23 | g7512.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 274 | 297 | - |
| 29 | g7512.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 298 | 320 | - |
| 13 | g7512.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 321 | 340 | - |
| 33 | g7512.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 341 | 368 | - |
| 22 | g7512.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 369 | 387 | - |
| 31 | g7512.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 388 | 407 | - |
| 15 | g7512.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 408 | 413 | - |
| 34 | g7512.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 414 | 439 | - |
| 21 | g7512.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 440 | 450 | - |
| 37 | g7512.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 451 | 470 | - |
| 14 | g7512.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 471 | 481 | - |
| 38 | g7512.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 482 | 504 | - |
| 20 | g7512.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 505 | 659 | - |
| 12 | g7512.t1 | SignalP_EUK | SignalP-TM | SignalP-TM | 1 | 18 | - |
| 55 | g7512.t1 | TIGRFAM | TIGR00840 | b_cpa1: sodium/hydrogen exchanger 3 | 151 | 517 | 8.6E-95 |
| 49 | g7512.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 38 | 57 | - |
| 48 | g7512.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 64 | 86 | - |
| 47 | g7512.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 157 | 174 | - |
| 51 | g7512.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 187 | 209 | - |
| 46 | g7512.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 224 | 243 | - |
| 42 | g7512.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 298 | 320 | - |
| 50 | g7512.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 342 | 364 | - |
| 44 | g7512.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 385 | 407 | - |
| 45 | g7512.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 417 | 439 | - |
| 43 | g7512.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 481 | 503 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0055085 | transmembrane transport | BP |
| GO:0015385 | sodium:proton antiporter activity | MF |
| GO:0016021 | integral component of membrane | CC |
| GO:0006885 | regulation of pH | BP |
| GO:0015299 | solute:proton antiporter activity | MF |
| GO:0006812 | cation transport | BP |
| GO:0006814 | sodium ion transport | BP |
KEGG
Orthology
- This transcript has been annotated with K12041 (solute carrier family 9 (sodium/hydrogen exchanger), member 6/7)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
