General information for g7512.t2

Gene loci information

Transcript annotation

This transcript has been annotated as Sodium/hydrogen exchanger 7.

Parent gene

The parent gene g7512 is located on chr_2: 24145511..24146415 (+ strand)

Gene structure

The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome	Gene	Transcript	Category	ID	Start	End
chr_2	g7512	g7512.t2	TSS	g7512.t2	24141805	24141805
chr_2	g7512	g7512.t2	isoform	g7512.t2	24141868	24145835
chr_2	g7512	g7512.t2	exon	g7512.t2.exon1	24141868	24141997
chr_2	g7512	g7512.t2	cds	g7512.t2.CDS1	24141868	24141997
chr_2	g7512	g7512.t2	exon	g7512.t2.exon2	24142112	24142204
chr_2	g7512	g7512.t2	cds	g7512.t2.CDS2	24142112	24142204
chr_2	g7512	g7512.t2	exon	g7512.t2.exon3	24142889	24143763
chr_2	g7512	g7512.t2	cds	g7512.t2.CDS3	24142889	24143763
chr_2	g7512	g7512.t2	exon	g7512.t2.exon4	24143823	24143994
chr_2	g7512	g7512.t2	cds	g7512.t2.CDS4	24143823	24143994
chr_2	g7512	g7512.t2	exon	g7512.t2.exon5	24144053	24144363
chr_2	g7512	g7512.t2	cds	g7512.t2.CDS5	24144053	24144363
chr_2	g7512	g7512.t2	exon	g7512.t2.exon6	24144756	24144874
chr_2	g7512	g7512.t2	cds	g7512.t2.CDS6	24144756	24144874
chr_2	g7512	g7512.t2	exon	g7512.t2.exon7	24144932	24145139
chr_2	g7512	g7512.t2	cds	g7512.t2.CDS7	24144932	24145139
chr_2	g7512	g7512.t2	exon	g7512.t2.exon8	24145797	24145835
chr_2	g7512	g7512.t2	cds	g7512.t2.CDS8	24145797	24145835
chr_2	g7512	g7512.t2	TTS	g7512.t2	24146047	24146047

Sequences

>g7512.t2 Gene=g7512 Length=1947
ATGAAAACTCTAATAATTGTGACTTTATTAGGATTAATAAATGACATAAGAGCAGACAAT
TTTGATATTTTAATAGATACAAAAGCAAACTCTATTCATCGACTGGATTCTTTGAATTTA
TTGATTTATTGTTCACTATTGGCACTCACTGTTCTGACAATATGGGTTTTTAAGTACAGA
AGAGTATCGTGGTTGAATGAGACAGGCTTAGCAGTTATTTATGGTCTCATTGTAGGAGCG
ATAATTCGTTTTGCTGGAAACAGTTCACCAACAACACATTTACGTGTTGAAGCTGATAAG
TCAACAAAATACAATGACACTCTACCACCTGATGCTTTGTGGTTAAAATTTCCAGGAAAT
TTAAATATTTCTGGCCCAACACAAAATCAAACTTATGCATACTCATTTCGTGGTCAACTT
TATGGCAATTTAAATGAAATCGATTTGAAAGCAACTTTCGATCCAGAAATTTTTTTCAAC
ATTATTCTACCGCCAATTATTTTCTATGCTGGTTATAGCTTGAAGCGAAAATATTTCTTT
AGAAATTTGGGAACAATTCTAACTTTTGCTATAATTGGAACAACTCTTTCGGCATTGCTG
ATTGGTGCACTTATGTATTGCTTTGTACAACTGATTTCAATTCGCGAAAGCTTTACCTTC
TTAGACACACTTTATTTTGGTGCACTCATAAGTCCAACCGATCCGCTCACAATTTTGGCA
ATATTTAGTGAGAAAAATGTTGATGTTAATCTATACGCTCTGGTTTTTGGTGAGAGCGTG
CTCAATGATGCCGTTGCAATAGTTTTGAGTGGAGCTATTCAAAATTATGGCGAGCATTAT
TCAAAAACAGGAGATTTTGAGACACATGCGTTTATACATGCTCTTAAAGACTTCTTTTTT
ATATTTTTCTTCTCACTGGTTGTCGGCACTTCAATGGGCTGTCTCACATCGCTTATGACA
AAGTTTACAAAAATTAGAGAATTCCCGCTACTTGAATCTGCATTATTTGTGCTCATGTCG
TACAGTACTTTCCTCATTGCTGAGGTTTTTGAATTGACTGGAGTTGTAGCTGTGCTATTT
TGTGGAATTTGTCAAGCACATTATACATTCAATAATTTATCAGAAGAGTCAAGGACAAGA
ACAAAGCAGTTGTTTGAGCTTTTGAACTTTTTAGCAGAAAATTTTATCTTTTCATATATT
GGTGTGTCGATGTTTTCATTTCCTCGACATCATTTTGATGCTCTTTTCATCATTGGTGGA
TTTTTATGTGCAATGATTGGTAGAGCAGTAAATGTTTATCCTTTAGCATGGGTAATTAAC
TTGGGACGAAAGCCTAAAATGCCTTGGAACTTTCAACATATGTTGTTCTTTGCTGGTCTT
CGTGGTGCAATGTCTTTTGCTCTTGCGATTCGCAACACTGTCTCAGAAGCACGTCAAACT
ATGCTCACATGTACATCATTAATTGTAATTGTGTCAGTACTTTTTCAAGGTGGTGCAGCA
AATTTCGTCCTACAATTTCTAAAAATTCCAATTGGAGTTGAAGATGAAACAGAGCAGCTA
ACTTATCAGTCTGTCAAAAGTGATTTGGAAAGTCCTGATCCCCATTCACCAAGTGGTAGT
GATCAACCTCAAACAAGTACATCAACTAGAAAGAATGAAAAAGCATTGTTGGCTAGAATA
TGGGGAAATTTCGATTCAAGATATATGAAGCCATTTTTAACAAATTCACGTCCAACACTG
TTAGAAACATTACCAGAATTTTTGACACCACTTGCACGAGTGCTTACTACAACCGAACAA
TTAAATCAAAGTGGTCGTACTAGGAAACTCGATTCAGATTCAGATTTATGCATAGATGAA
ACAAATGGCGGTGGTGGTGGAAGTACGAGAAGAAATTCAATAAGTCGAGTTCTACCACGA
AGTCCTCATTCATCAGCTATTATTTGA

>g7512.t2 Gene=g7512 Length=648
MKTLIIVTLLGLINDIRADNFDILIDTKANSIHRLDSLNLLIYCSLLALTVLTIWVFKYR
RVSWLNETGLAVIYGLIVGAIIRFAGNSSPTTHLRVEADKSTKYNDTLPPDALWLKFPGN
LNISGPTQNQTYAYSFRGQLYGNLNEIDLKATFDPEIFFNIILPPIIFYAGYSLKRKYFF
RNLGTILTFAIIGTTLSALLIGALMYCFVQLISIRESFTFLDTLYFGALISPTDPLTILA
IFSEKNVDVNLYALVFGESVLNDAVAIVLSGAIQNYGEHYSKTGDFETHAFIHALKDFFF
IFFFSLVVGTSMGCLTSLMTKFTKIREFPLLESALFVLMSYSTFLIAEVFELTGVVAVLF
CGICQAHYTFNNLSEESRTRTKQLFELLNFLAENFIFSYIGVSMFSFPRHHFDALFIIGG
FLCAMIGRAVNVYPLAWVINLGRKPKMPWNFQHMLFFAGLRGAMSFALAIRNTVSEARQT
MLTCTSLIVIVSVLFQGGAANFVLQFLKIPIGVEDETEQLTYQSVKSDLESPDPHSPSGS
DQPQTSTSTRKNEKALLARIWGNFDSRYMKPFLTNSRPTLLETLPEFLTPLARVLTTTEQ
LNQSGRTRKLDSDSDLCIDETNGGGGGSTRRNSISRVLPRSPHSSAII

Protein features from InterProScan

	Transcript	Database	ID	Name	Start	End	E.value
52	g7512.t2	MobiDBLite	mobidb-lite	consensus disorder prediction	524	552	-
53	g7512.t2	MobiDBLite	mobidb-lite	consensus disorder prediction	601	648	-
54	g7512.t2	MobiDBLite	mobidb-lite	consensus disorder prediction	625	648	-
2	g7512.t2	PANTHER	PTHR10110	SODIUM/HYDROGEN EXCHANGER	20	620	1.9E-194
3	g7512.t2	PANTHER	PTHR10110:SF94	SODIUM/HYDROGEN EXCHANGER 6	20	620	1.9E-194
5	g7512.t2	PRINTS	PR01088	Na+/H+ exchanger isoform 6 (NHE6) signature	30	54	8.2E-15
4	g7512.t2	PRINTS	PR01088	Na+/H+ exchanger isoform 6 (NHE6) signature	55	73	8.2E-15
7	g7512.t2	PRINTS	PR01088	Na+/H+ exchanger isoform 6 (NHE6) signature	74	100	8.2E-15
10	g7512.t2	PRINTS	PR01084	Na+/H+ exchanger signature	157	168	7.1E-18
11	g7512.t2	PRINTS	PR01084	Na+/H+ exchanger signature	171	185	7.1E-18
8	g7512.t2	PRINTS	PR01084	Na+/H+ exchanger signature	186	194	7.1E-18
9	g7512.t2	PRINTS	PR01084	Na+/H+ exchanger signature	227	237	7.1E-18
6	g7512.t2	PRINTS	PR01088	Na+/H+ exchanger isoform 6 (NHE6) signature	598	619	8.2E-15
1	g7512.t2	Pfam	PF00999	Sodium/hydrogen exchanger family	46	504	6.7E-73
26	g7512.t2	Phobius	SIGNAL_PEPTIDE	Signal peptide region	1	18	-
27	g7512.t2	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.	1	2	-
28	g7512.t2	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.	3	13	-
41	g7512.t2	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.	14	18	-
25	g7512.t2	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.	19	36	-
32	g7512.t2	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.	37	57	-
18	g7512.t2	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.	58	68	-
30	g7512.t2	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.	69	86	-
19	g7512.t2	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.	87	156	-
35	g7512.t2	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.	157	174	-
17	g7512.t2	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.	175	185	-
39	g7512.t2	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.	186	212	-
24	g7512.t2	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.	213	223	-
40	g7512.t2	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.	224	242	-
16	g7512.t2	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.	243	248	-
36	g7512.t2	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.	249	273	-
23	g7512.t2	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.	274	297	-
29	g7512.t2	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.	298	320	-
13	g7512.t2	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.	321	340	-
33	g7512.t2	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.	341	368	-
21	g7512.t2	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.	369	387	-
31	g7512.t2	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.	388	407	-
15	g7512.t2	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.	408	413	-
34	g7512.t2	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.	414	439	-
20	g7512.t2	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.	440	450	-
37	g7512.t2	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.	451	470	-
14	g7512.t2	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.	471	481	-
38	g7512.t2	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.	482	504	-
22	g7512.t2	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.	505	648	-
12	g7512.t2	SignalP_EUK	SignalP-TM	SignalP-TM	1	18	-
55	g7512.t2	TIGRFAM	TIGR00840	b_cpa1: sodium/hydrogen exchanger 3	151	517	4.3E-95
49	g7512.t2	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.	38	57	-
48	g7512.t2	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.	64	86	-
47	g7512.t2	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.	157	174	-
51	g7512.t2	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.	187	209	-
46	g7512.t2	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.	224	243	-
42	g7512.t2	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.	298	320	-
50	g7512.t2	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.	342	364	-
44	g7512.t2	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.	385	407	-
45	g7512.t2	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.	417	439	-
43	g7512.t2	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.	481	503	-

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID	TERM	ONTOLOGY
GO:0055085	transmembrane transport	BP
GO:0015385	sodium:proton antiporter activity	MF
GO:0016021	integral component of membrane	CC
GO:0006885	regulation of pH	BP
GO:0015299	solute:proton antiporter activity	MF
GO:0006812	cation transport	BP
GO:0006814	sodium ion transport	BP

KEGG

Orthology

This transcript has been annotated with K12041 (solute carrier family 9 (sodium/hydrogen exchanger), member 6/7)

Pathway

This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.