Gene loci information

Transcript annotation

  • This transcript has been annotated as Sodium/hydrogen exchanger 7.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_2 g7512 g7512.t5 TSS g7512.t5 24141805 24141805
chr_2 g7512 g7512.t5 isoform g7512.t5 24141868 24146415
chr_2 g7512 g7512.t5 exon g7512.t5.exon1 24141868 24141997
chr_2 g7512 g7512.t5 exon g7512.t5.exon2 24142112 24142208
chr_2 g7512 g7512.t5 cds g7512.t5.CDS1 24142202 24142208
chr_2 g7512 g7512.t5 exon g7512.t5.exon3 24142889 24143763
chr_2 g7512 g7512.t5 cds g7512.t5.CDS2 24142889 24143763
chr_2 g7512 g7512.t5 exon g7512.t5.exon4 24143823 24143994
chr_2 g7512 g7512.t5 cds g7512.t5.CDS3 24143823 24143994
chr_2 g7512 g7512.t5 exon g7512.t5.exon5 24144053 24144363
chr_2 g7512 g7512.t5 cds g7512.t5.CDS4 24144053 24144363
chr_2 g7512 g7512.t5 exon g7512.t5.exon6 24144756 24144874
chr_2 g7512 g7512.t5 cds g7512.t5.CDS5 24144756 24144874
chr_2 g7512 g7512.t5 exon g7512.t5.exon7 24144932 24145143
chr_2 g7512 g7512.t5 cds g7512.t5.CDS6 24144932 24145143
chr_2 g7512 g7512.t5 exon g7512.t5.exon8 24145797 24146415
chr_2 g7512 g7512.t5 cds g7512.t5.CDS7 24145797 24145909
chr_2 g7512 g7512.t5 TTS g7512.t5 NA NA

Sequences

>g7512.t5 Gene=g7512 Length=2535
ATGAAAACTCTAATAATTGTGACTTTATTAGGATTAATAAATGACATAAGAGCAGACAAT
TTTGATATTTTAATAGATACAAAAGCAAACTCTATTCATCGACTGGATTCTTTGAATTTA
TTGATTTATTGTTCACTATTGGCACTCACTGTTCTGACAATATGGGTTTTTAAGTACAGA
AGAGTATCGTGGTTGAATGAGACAGGCTTAGCAGTTATTTATGGTAGGTCTCATTGTAGG
AGCGATAATTCGTTTTGCTGGAAACAGTTCACCAACAACACATTTACGTGTTGAAGCTGA
TAAGTCAACAAAATACAATGACACTCTACCACCTGATGCTTTGTGGTTAAAATTTCCAGG
AAATTTAAATATTTCTGGCCCAACACAAAATCAAACTTATGCATACTCATTTCGTGGTCA
ACTTTATGGCAATTTAAATGAAATCGATTTGAAAGCAACTTTCGATCCAGAAATTTTTTT
CAACATTATTCTACCGCCAATTATTTTCTATGCTGGTTATAGCTTGAAGCGAAAATATTT
CTTTAGAAATTTGGGAACAATTCTAACTTTTGCTATAATTGGAACAACTCTTTCGGCATT
GCTGATTGGTGCACTTATGTATTGCTTTGTACAACTGATTTCAATTCGCGAAAGCTTTAC
CTTCTTAGACACACTTTATTTTGGTGCACTCATAAGTCCAACCGATCCGCTCACAATTTT
GGCAATATTTAGTGAGAAAAATGTTGATGTTAATCTATACGCTCTGGTTTTTGGTGAGAG
CGTGCTCAATGATGCCGTTGCAATAGTTTTGAGTGGAGCTATTCAAAATTATGGCGAGCA
TTATTCAAAAACAGGAGATTTTGAGACACATGCGTTTATACATGCTCTTAAAGACTTCTT
TTTTATATTTTTCTTCTCACTGGTTGTCGGCACTTCAATGGGCTGTCTCACATCGCTTAT
GACAAAGTTTACAAAAATTAGAGAATTCCCGCTACTTGAATCTGCATTATTTGTGCTCAT
GTCGTACAGTACTTTCCTCATTGCTGAGGTTTTTGAATTGACTGGAGTTGTAGCTGTGCT
ATTTTGTGGAATTTGTCAAGCACATTATACATTCAATAATTTATCAGAAGAGTCAAGGAC
AAGAACAAAGCAGTTGTTTGAGCTTTTGAACTTTTTAGCAGAAAATTTTATCTTTTCATA
TATTGGTGTGTCGATGTTTTCATTTCCTCGACATCATTTTGATGCTCTTTTCATCATTGG
TGGATTTTTATGTGCAATGATTGGTAGAGCAGTAAATGTTTATCCTTTAGCATGGGTAAT
TAACTTGGGACGAAAGCCTAAAATGCCTTGGAACTTTCAACATATGTTGTTCTTTGCTGG
TCTTCGTGGTGCAATGTCTTTTGCTCTTGCGATTCGCAACACTGTCTCAGAAGCACGTCA
AACTATGCTCACATGTACATCATTAATTGTAATTGTGTCAGTACTTTTTCAAGGTGGTGC
AGCAAATTTCGTCCTACAATTTCTAAAAATTCCAATTGGAGTTGAAGATGAAACAGAGCA
GCTAACTTATCAGTCTGTCAAAAGTGATTTGGAAAGTCCTGATCCCCATTCACCAAGTGG
TAGTGATCAACCTCAAACAAGTACATCAACTAGAAAGAATGAAAAAGCATTGTTGGCTAG
AATATGGGGAAATTTCGATTCAAGATATATGAAGCCATTTTTAACAAATTCACGTCCAAC
ACTGTTAGAAACATTACCAGAATTTTTGACACCACTTGCACGAGTGCTTACTACAACCGA
ACAATTAAATCAAAGTGGTCGTACTAGGAAACTCGATTCAGATTCAGATTTATGCATAGA
TGAAACAAATGGCGGTGGTGGTGGAAGTACGAGAAGAAATTCAATAAGTCGAGTGAGTTC
TACCACGAAGTCCTCATTCATCAGCTATTATTTGAACACACATAAATATACTTATTATTA
TTTTCATTTGTTGATCCTTGGTTCCTCGGTCTCAGAGTCTATTAATTAATTATAACCCTT
GTTAAAATTTTACCTTCCTCGTTAGCTTATAATTATTACAAACAAACCAACCAACAAAAT
AATTGTATTCTGGGGGTGCTACATAGTTATTATTAGAAATTTTAAATTTCATTTTATTAT
TTTATCGAAAAAAAAGGAAAAGGAATGTGAAAATGAAAATTTTAAATATTATTATTGAAC
TGTGATTTTATAAAAAGAAAAAAATTGGTTTATTTAGTTTATAGGTTGATAAAAATTTTA
CCGAAAGAAGAGTATAGCATGTCAAACATTTTTTCTCTATAGTTTATTTAAATTATTCAA
TACTTTTTTTATGTTCTATCTTTATAAGGTTAATCAGAATAGTTTTTCTTTTCGATTTAA
TAAACAACAAAATTTATTTATTTAAGTCGCAAAAATTGCAACAACTTTAAAATGTCAGAT
TGTTTTCTATTTTTAGTTTAGTAAATAAAATTTTTTTCCTATGGTGGACAAAAAAATGAA
AAAATATTGCCTTTT

>g7512.t5 Gene=g7512 Length=602
MVGLIVGAIIRFAGNSSPTTHLRVEADKSTKYNDTLPPDALWLKFPGNLNISGPTQNQTY
AYSFRGQLYGNLNEIDLKATFDPEIFFNIILPPIIFYAGYSLKRKYFFRNLGTILTFAII
GTTLSALLIGALMYCFVQLISIRESFTFLDTLYFGALISPTDPLTILAIFSEKNVDVNLY
ALVFGESVLNDAVAIVLSGAIQNYGEHYSKTGDFETHAFIHALKDFFFIFFFSLVVGTSM
GCLTSLMTKFTKIREFPLLESALFVLMSYSTFLIAEVFELTGVVAVLFCGICQAHYTFNN
LSEESRTRTKQLFELLNFLAENFIFSYIGVSMFSFPRHHFDALFIIGGFLCAMIGRAVNV
YPLAWVINLGRKPKMPWNFQHMLFFAGLRGAMSFALAIRNTVSEARQTMLTCTSLIVIVS
VLFQGGAANFVLQFLKIPIGVEDETEQLTYQSVKSDLESPDPHSPSGSDQPQTSTSTRKN
EKALLARIWGNFDSRYMKPFLTNSRPTLLETLPEFLTPLARVLTTTEQLNQSGRTRKLDS
DSDLCIDETNGGGGGSTRRNSISRVSSTTKSSFISYYLNTHKYTYYYFHLLILGSSVSES
IN

Protein features from InterProScan

Transcript Database ID Name Start End E.value
19 g7512.t5 MobiDBLite mobidb-lite consensus disorder prediction 452 480 -
2 g7512.t5 PANTHER PTHR10110 SODIUM/HYDROGEN EXCHANGER 3 549 1.1E-172
3 g7512.t5 PANTHER PTHR10110:SF94 SODIUM/HYDROGEN EXCHANGER 6 3 549 1.1E-172
4 g7512.t5 PRINTS PR01088 Na+/H+ exchanger isoform 6 (NHE6) signature 71 84 2.6E-8
9 g7512.t5 PRINTS PR01084 Na+/H+ exchanger signature 85 96 5.5E-18
8 g7512.t5 PRINTS PR01084 Na+/H+ exchanger signature 99 113 5.5E-18
10 g7512.t5 PRINTS PR01084 Na+/H+ exchanger signature 114 122 5.5E-18
7 g7512.t5 PRINTS PR01084 Na+/H+ exchanger signature 155 165 5.5E-18
5 g7512.t5 PRINTS PR01088 Na+/H+ exchanger isoform 6 (NHE6) signature 475 493 2.6E-8
6 g7512.t5 PRINTS PR01088 Na+/H+ exchanger isoform 6 (NHE6) signature 499 527 2.6E-8
1 g7512.t5 Pfam PF00999 Sodium/hydrogen exchanger family 76 432 4.1E-73
29 g7512.t5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 1 84 -
37 g7512.t5 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 85 102 -
25 g7512.t5 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 103 113 -
39 g7512.t5 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 114 140 -
30 g7512.t5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 141 151 -
40 g7512.t5 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 152 170 -
23 g7512.t5 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 171 176 -
41 g7512.t5 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 177 201 -
31 g7512.t5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 202 225 -
38 g7512.t5 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 226 248 -
22 g7512.t5 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 249 268 -
33 g7512.t5 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 269 296 -
28 g7512.t5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 297 315 -
36 g7512.t5 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 316 335 -
21 g7512.t5 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 336 341 -
35 g7512.t5 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 342 367 -
27 g7512.t5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 368 378 -
32 g7512.t5 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 379 398 -
24 g7512.t5 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 399 409 -
34 g7512.t5 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 410 432 -
26 g7512.t5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 433 602 -
20 g7512.t5 TIGRFAM TIGR00840 b_cpa1: sodium/hydrogen exchanger 3 79 445 3.5E-95
12 g7512.t5 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 85 102 -
13 g7512.t5 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 115 137 -
17 g7512.t5 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 152 171 -
14 g7512.t5 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 226 248 -
15 g7512.t5 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 270 292 -
11 g7512.t5 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 313 335 -
16 g7512.t5 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 345 367 -
18 g7512.t5 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 409 431 -

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0055085 transmembrane transport BP
GO:0015385 sodium:proton antiporter activity MF
GO:0016021 integral component of membrane CC
GO:0006885 regulation of pH BP
GO:0015299 solute:proton antiporter activity MF
GO:0006812 cation transport BP
GO:0006814 sodium ion transport BP

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values