General information for g7709.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Tyrosine-protein kinase Abl.
Parent gene
- The parent gene g7709 is located on chr_2: 25410535..25411729 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g7709 | g7709.t1 | TTS | g7709.t1 | 25387978 | 25387978 |
| chr_2 | g7709 | g7709.t1 | isoform | g7709.t1 | 25388207 | 25411319 |
| chr_2 | g7709 | g7709.t1 | exon | g7709.t1.exon1 | 25388207 | 25389627 |
| chr_2 | g7709 | g7709.t1 | cds | g7709.t1.CDS1 | 25388207 | 25389627 |
| chr_2 | g7709 | g7709.t1 | exon | g7709.t1.exon2 | 25389697 | 25390446 |
| chr_2 | g7709 | g7709.t1 | cds | g7709.t1.CDS2 | 25389697 | 25390446 |
| chr_2 | g7709 | g7709.t1 | exon | g7709.t1.exon3 | 25390794 | 25390858 |
| chr_2 | g7709 | g7709.t1 | cds | g7709.t1.CDS3 | 25390794 | 25390858 |
| chr_2 | g7709 | g7709.t1 | exon | g7709.t1.exon4 | 25390932 | 25391061 |
| chr_2 | g7709 | g7709.t1 | cds | g7709.t1.CDS4 | 25390932 | 25391061 |
| chr_2 | g7709 | g7709.t1 | exon | g7709.t1.exon5 | 25391154 | 25391328 |
| chr_2 | g7709 | g7709.t1 | cds | g7709.t1.CDS5 | 25391154 | 25391328 |
| chr_2 | g7709 | g7709.t1 | exon | g7709.t1.exon6 | 25391389 | 25391606 |
| chr_2 | g7709 | g7709.t1 | cds | g7709.t1.CDS6 | 25391389 | 25391606 |
| chr_2 | g7709 | g7709.t1 | exon | g7709.t1.exon7 | 25391669 | 25392116 |
| chr_2 | g7709 | g7709.t1 | cds | g7709.t1.CDS7 | 25391669 | 25392116 |
| chr_2 | g7709 | g7709.t1 | exon | g7709.t1.exon8 | 25392186 | 25392323 |
| chr_2 | g7709 | g7709.t1 | cds | g7709.t1.CDS8 | 25392186 | 25392323 |
| chr_2 | g7709 | g7709.t1 | exon | g7709.t1.exon9 | 25392416 | 25393125 |
| chr_2 | g7709 | g7709.t1 | cds | g7709.t1.CDS9 | 25392416 | 25393125 |
| chr_2 | g7709 | g7709.t1 | exon | g7709.t1.exon10 | 25411160 | 25411319 |
| chr_2 | g7709 | g7709.t1 | cds | g7709.t1.CDS10 | 25411160 | 25411319 |
| chr_2 | g7709 | g7709.t1 | TSS | g7709.t1 | 25411729 | 25411729 |
Sequences
>g7709.t1 Gene=g7709 Length=4215
ATGGGCAATCAACAATCGGTTAAATCGGAGCCCAAAACGATACCAAATCTCTCGTCTATT
CAAGGCGCGGTTCCATCAAGTATAAGATCAAGCCGCTCTAAACCGAGAGTTCCAAAAGAT
TCTAGGACGTTAGGATCAAATATTTTTACTGAACATAGTGAAGCATTATTGCAATCTCGA
CCGCTTCCACATGTGCCCCATAATCCAGTCGTAGACGTTGTTTTAGAAAGTTCAGACCAT
AGTGGTACATTATTATCGCAAGGCAGTAATACTAGTAATCCACAGTCAACATTCGAGACA
GCGAACCGATGGACATCAAAAGAGAATTTACTGACACCAGCACCAGAGGACGATGATCCG
CAATTGTTTGTAGCACTTTATGATTTTAAAGCAGGCGGCGAGAATCAATTAAGTTTAAGA
AAGGGTGAACAAGTTAGAATACTTTCATATAATAAATCCGGGGAGTGGTGTGAAGCACAT
TCTGATTCTGGTCATGTTGGATGGGTGCCATCAAATTATGTAACACCATTGAATTCGTTA
GAGAAGCATTCATGGTATCATGGGCCCATTTCGCGTAACGCAGCAGAATATCTATTGAGC
TCAGGAATTAATGGAAGTTTTTTAGTTCGTGAATCCGAGAGTTCGCCAGGTCAAAGATCA
ATTAGTTTACGCTATGAAGGTCGCGTGTATCATTATCGTATTCAAGAAGATACTGATGGA
AAAGTTTTCGTAACTGCCGAATATAAATTTAATACCTTAGCCGAACTCGTACACCATCAT
AGTGTTCTTCATGAGGGTCACGGATTAATTACGCCATTATTATATCCAGCACCGAAACAA
AACAAACCCACAGTCTTTCCACTTAGTCCGGAACCAGATGAGTGGGAAATTAGTCGAACG
GATATTGTGATGAAACATAAACTCGGTGGTGGTCAATATGGTGAAGTTTATGAGGCAATT
TGGAAACGATATGGAAACACTGTAGCTGTCAAGACACTTAAAGAGGAGACCATGCCATTC
AAAGACTTTTTAGAGGAAGCAGCAATCATGAAGGAAATGAAGCATCCGAATTTGGTGCAA
TTGATTGGTGTTTGTACAAGAGAACCACCTTTTTATATTATCACAGAGTTCATGAGTCAT
GGCAATCTTCTTGATTTTCTTCGATCTGCTGGTCGTGAGACACTCGACGCTGTTGCGCTT
CTTTACATGGCGACGCAAATTGCTTCCGGCATGAGTTATTTGGAGAGTAGAAATTTCATT
CATCGTGATCTTGCAGCTCGTAATTGTTTGGTTGGTGAAAATAATCTTGTCAAAGTTGCT
GATTTTGGACTTGCACGTTTAATGCGTGATGATACATACACGGCACATGCAGGAGCTAAA
TTTCCAATCAAATGGACTGCTCCAGAAGGATTAGCGTACAATAAATTTTCAACTAAATCA
GATGTATGGGCTTTCGGTGTACTGCTTTGGGAAATTGCAACTTATGGCATGAGTCCTTAT
CCAGCAATAGATTTGACAGATGTATATCATCGACTTGAATCAGGTTATAGAATGGAAAGA
CCACAAGGATGTCCACCAGAGGTTTATGAATTAATGAGAAAATGTTGGCAATGGAATCCA
GCAGATCGACCAACCTTCAAAAGTATCCATCATGATTTGGAGCATATGTTTCAAGAATCA
TCAATTACTGAAGCTGTAGAAAAGCAATTGCAAGGAACAACTCCACCACAACCTAGTCTC
ACTCCGCAAATGAGTAAAAAGCCACAAATGGGAACGCACGTAGTTCAACAACATCAACAA
CAACAACAACAGCAGCAGCACGAACAGCAAGCAATTACACCAATTTCAGAAACTGGTTCA
TCATCAAAATTGAGTACTTTTGGATCTACTGGAAAAACAGGTTCAGTTGTGCAGATGAGA
AGACCAACTAATAAGAACAAACAAGGAAAAACAGCACCAGCTCCTCCAAAAAGAACATCA
CTGCTCTCATCTAGTCGCGACTCGCAATATCGTGATGACGAAAGAAATATTGATGAGATA
AATGGTTTTTCACGAGAAATTGCTAATTTGGCATCAAGAGCAGATTCAGAGAATGAAAAT
CAAGAAATTACACCAGATACTGATACGGATAGCCAAGAGCATTTAGCAAAACACCAAATG
ATGCCGCCACCTCATTCATCGCAATCTGCATTCAAACGAGCACCAATGATGGGAACAAGA
TTAGATGCACGTAACAGTAAATCGAGATCGAGTCAACGAAAAACACCATTAGGAAATGCA
CCATTGAATCAACAGCAGTCATCACAAAATCAACAACAGCAGCAGCAACAACAAGGAACG
GTAGTTGGAGCATTAGAAGTTCAGAATGTTAAACGTGCGATAAATCGTTATGGAACATTG
CCAAAATCGAGCCGCATTGGCGCTTATCTCGAATCATTACGACAGAATGGTGAAAATGAA
TTACCACAGAATGTTGTGCAGCAACAACAACAATTAAATACAGCACAAAACATTTTGGGA
ATTCCAACTGTCGAACAATTGCCATCCACACACTCACCCCGTACTGCACTAAAAGTTCAA
CCGCAAATGATTAGAAGTAATTCGTCTGGTGGCGTTACGATGACAAATTCTGCAACTGCT
AGTCTTACAAAATTGCAGCGACATCGAACGACCACTGATGGAACGATGATGACAACATTC
TCTAGTTTCCGTAGTACCGGAAATAATAATAGTCCAAAGAGAAATATCCCAGTGACGTTA
GCTGAACTTGAATTTCCTCCTCCACCACCACCAGAAGAATTTGACGGCAATCAATTCCAT
CCTGACATTCCATCAATAAAGAATAACAACCAAATTAATAATAATGATGTTTCAAATACT
GCTCCAAGTGTTGAAGAGGCAAGCACTCGTTTTGGAGTGAGTTTGCGAAAACGTGAACCA
TCGACTGATTCATGTAGTTCTCTCGGTAGTCCTGCAAATGATCTCAATGAGCCATTAAAA
AAGGCACCATATTTGAATAATAGTGACAATGTGCCAAAAAGCATTGATCCAGCCGCTATG
TTAGTATCAGAACTTGCTGAAACAATGCAGATTCCAAAACCTGATGCTGCCCCACCTAAA
CCGTCAGATCTTCTTGCCAGAAAACCAAGTACACCAAAATCAATTCTTCCAGCTTCATCA
TCAAATAATGCCGAAACAAATGGCATAACATTCAAAGCTCAACTAAAAAAAGTCGAACCG
AAAAAAATGACCAAGGAAGATGACATAACTACAAGTATAATTGATTTCAAGTCTCGTTTA
CGTAAAGTAGATCATGCAGACACTGAGAACAATGCTTCCGAAGACGTTAATAAGCTTAAC
AACAAAAGTGATAGTAAAATAATAAGTGATGAATTAACATGCAACAGTAACAACAGCAAA
ATGAAACCAAATATACATAACAATAATATTAATAATAATAATAATGTGAGCAGTAAAAAG
ACTGAAATCAAAATAGATGTGGCTGACGATAAAAAGAAAGAAAGTAATGGCGATGGAAAG
CATCAGCCACCATCAAGTGATGAAGATGATAAACGAAAGAGCACTGGGAGCATAAGCAGT
TTGAAGAAATTATGGGAAGCAAAACCATCAGCAAATACTGAACATACAAATCAATTGAGT
CCAAAAATGGGAAGTGCAATCAAAAAGAAGGATGATTGTGACGATAATCATAATATTAAC
ACATCTCCAAATGGAATGCATCAACATGAGACGAGCATGGAACCGCCAGTTGCAAAGAAG
CCAGCTGTTCCTGTAAAACCTTCAAAATTTACAATTTATGCTACACCAATACAACAATCA
AGCATAAAGGGAGGCATTGAAAATAATAATCTAGCAACAGCAAATTCTGCGGCTCCTGCA
AGTCGTGAAAATATTCTCGAATTGGTACAAATGGTTGAATGCAATTTAAAGATTCCAGTG
AATTTGATTACAGCAACACAATGGTTACAATTGAGTGACAAATTAAATATTATTCAATCA
TCTTGTGTAACATATGCCGATACTGAAACGATGCCACCACACACCAAATTTCAATTTCGC
GAATTGGTTACGCGAGTTGAAAATCAATCAAATTGTTTGCGCACAGCAGGGCAAAAGAAT
GTTCAGGACAATGAAAAATTGCTAATTGAAGTTGGGCAATCACTCAAACAGCTTTCAAAT
GCATTGCATAGGTAA
>g7709.t1 Gene=g7709 Length=1404
MGNQQSVKSEPKTIPNLSSIQGAVPSSIRSSRSKPRVPKDSRTLGSNIFTEHSEALLQSR
PLPHVPHNPVVDVVLESSDHSGTLLSQGSNTSNPQSTFETANRWTSKENLLTPAPEDDDP
QLFVALYDFKAGGENQLSLRKGEQVRILSYNKSGEWCEAHSDSGHVGWVPSNYVTPLNSL
EKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRIQEDTDG
KVFVTAEYKFNTLAELVHHHSVLHEGHGLITPLLYPAPKQNKPTVFPLSPEPDEWEISRT
DIVMKHKLGGGQYGEVYEAIWKRYGNTVAVKTLKEETMPFKDFLEEAAIMKEMKHPNLVQ
LIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNFI
HRDLAARNCLVGENNLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKS
DVWAFGVLLWEIATYGMSPYPAIDLTDVYHRLESGYRMERPQGCPPEVYELMRKCWQWNP
ADRPTFKSIHHDLEHMFQESSITEAVEKQLQGTTPPQPSLTPQMSKKPQMGTHVVQQHQQ
QQQQQQHEQQAITPISETGSSSKLSTFGSTGKTGSVVQMRRPTNKNKQGKTAPAPPKRTS
LLSSSRDSQYRDDERNIDEINGFSREIANLASRADSENENQEITPDTDTDSQEHLAKHQM
MPPPHSSQSAFKRAPMMGTRLDARNSKSRSSQRKTPLGNAPLNQQQSSQNQQQQQQQQGT
VVGALEVQNVKRAINRYGTLPKSSRIGAYLESLRQNGENELPQNVVQQQQQLNTAQNILG
IPTVEQLPSTHSPRTALKVQPQMIRSNSSGGVTMTNSATASLTKLQRHRTTTDGTMMTTF
SSFRSTGNNNSPKRNIPVTLAELEFPPPPPPEEFDGNQFHPDIPSIKNNNQINNNDVSNT
APSVEEASTRFGVSLRKREPSTDSCSSLGSPANDLNEPLKKAPYLNNSDNVPKSIDPAAM
LVSELAETMQIPKPDAAPPKPSDLLARKPSTPKSILPASSSNNAETNGITFKAQLKKVEP
KKMTKEDDITTSIIDFKSRLRKVDHADTENNASEDVNKLNNKSDSKIISDELTCNSNNSK
MKPNIHNNNINNNNNVSSKKTEIKIDVADDKKKESNGDGKHQPPSSDEDDKRKSTGSISS
LKKLWEAKPSANTEHTNQLSPKMGSAIKKKDDCDDNHNINTSPNGMHQHETSMEPPVAKK
PAVPVKPSKFTIYATPIQQSSIKGGIENNNLATANSAAPASRENILELVQMVECNLKIPV
NLITATQWLQLSDKLNIIQSSCVTYADTETMPPHTKFQFRELVTRVENQSNCLRTAGQKN
VQDNEKLLIEVGQSLKQLSNALHR
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 30 | g7709.t1 | CDD | cd11850 | SH3_Abl | 122 | 176 | 7.55378E-29 |
| 29 | g7709.t1 | CDD | cd09935 | SH2_ABL | 181 | 276 | 2.00147E-59 |
| 28 | g7709.t1 | CDD | cd05052 | PTKc_Abl | 295 | 557 | 0.0 |
| 27 | g7709.t1 | Coils | Coil | Coil | 1395 | 1404 | - |
| 24 | g7709.t1 | Gene3D | G3DSA:2.30.30.40 | SH3 Domains | 117 | 172 | 2.0E-25 |
| 26 | g7709.t1 | Gene3D | G3DSA:3.30.505.10 | SHC Adaptor Protein | 173 | 290 | 3.2E-44 |
| 23 | g7709.t1 | Gene3D | G3DSA:3.30.200.20 | Phosphorylase Kinase; domain 1 | 291 | 377 | 6.6E-33 |
| 25 | g7709.t1 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 379 | 623 | 3.7E-60 |
| 40 | g7709.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1 | 46 | - |
| 42 | g7709.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1 | 32 | - |
| 41 | g7709.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 81 | 106 | - |
| 38 | g7709.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 567 | 650 | - |
| 43 | g7709.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 567 | 777 | - |
| 44 | g7709.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 667 | 681 | - |
| 37 | g7709.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 750 | 777 | - |
| 48 | g7709.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 971 | 994 | - |
| 39 | g7709.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 979 | 993 | - |
| 45 | g7709.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1139 | 1161 | - |
| 47 | g7709.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1139 | 1223 | - |
| 46 | g7709.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1162 | 1197 | - |
| 5 | g7709.t1 | PANTHER | PTHR24418:SF162 | TYROSINE-PROTEIN KINASE ABL1 | 86 | 563 | 2.6E-208 |
| 6 | g7709.t1 | PANTHER | PTHR24418 | TYROSINE-PROTEIN KINASE | 86 | 563 | 2.6E-208 |
| 18 | g7709.t1 | PRINTS | PR00452 | SH3 domain signature | 121 | 131 | 2.2E-6 |
| 19 | g7709.t1 | PRINTS | PR00452 | SH3 domain signature | 135 | 150 | 2.2E-6 |
| 17 | g7709.t1 | PRINTS | PR00452 | SH3 domain signature | 165 | 177 | 2.2E-6 |
| 9 | g7709.t1 | PRINTS | PR00401 | SH2 domain signature | 185 | 199 | 2.8E-11 |
| 8 | g7709.t1 | PRINTS | PR00401 | SH2 domain signature | 204 | 214 | 2.8E-11 |
| 11 | g7709.t1 | PRINTS | PR00401 | SH2 domain signature | 216 | 227 | 2.8E-11 |
| 10 | g7709.t1 | PRINTS | PR00401 | SH2 domain signature | 228 | 238 | 2.8E-11 |
| 7 | g7709.t1 | PRINTS | PR00401 | SH2 domain signature | 249 | 263 | 2.8E-11 |
| 14 | g7709.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 375 | 388 | 7.7E-38 |
| 16 | g7709.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 413 | 431 | 7.7E-38 |
| 12 | g7709.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 461 | 471 | 7.7E-38 |
| 13 | g7709.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 480 | 502 | 7.7E-38 |
| 15 | g7709.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 524 | 546 | 7.7E-38 |
| 1 | g7709.t1 | Pfam | PF00018 | SH3 domain | 124 | 171 | 1.8E-12 |
| 2 | g7709.t1 | Pfam | PF00017 | SH2 domain | 185 | 260 | 2.4E-24 |
| 3 | g7709.t1 | Pfam | PF07714 | Protein tyrosine and serine/threonine kinase | 303 | 553 | 4.1E-99 |
| 4 | g7709.t1 | Pfam | PF08919 | F-actin binding | 1300 | 1404 | 8.2E-28 |
| 36 | g7709.t1 | ProSitePatterns | PS00107 | Protein kinases ATP-binding region signature. | 308 | 341 | - |
| 35 | g7709.t1 | ProSitePatterns | PS00109 | Tyrosine protein kinases specific active-site signature. | 419 | 431 | - |
| 49 | g7709.t1 | ProSiteProfiles | PS50002 | Src homology 3 (SH3) domain profile. | 118 | 179 | 26.49 |
| 50 | g7709.t1 | ProSiteProfiles | PS50001 | Src homology 2 (SH2) domain profile. | 185 | 277 | 23.188 |
| 51 | g7709.t1 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 302 | 558 | 43.001 |
| 32 | g7709.t1 | SMART | SM00326 | SH3_2 | 121 | 178 | 1.6E-17 |
| 33 | g7709.t1 | SMART | SM00252 | SH2_5 | 183 | 266 | 1.2E-31 |
| 31 | g7709.t1 | SMART | SM00219 | tyrkin_6 | 302 | 553 | 2.3E-146 |
| 34 | g7709.t1 | SMART | SM00808 | fabda | 1255 | 1404 | 4.8E-41 |
| 22 | g7709.t1 | SUPERFAMILY | SSF50044 | SH3-domain | 113 | 159 | 2.88E-5 |
| 21 | g7709.t1 | SUPERFAMILY | SSF55550 | SH2 domain | 154 | 321 | 6.36E-37 |
| 20 | g7709.t1 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 292 | 567 | 3.1E-86 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004713 | protein tyrosine kinase activity | MF |
| GO:0005524 | ATP binding | MF |
| GO:0005515 | protein binding | MF |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0006468 | protein phosphorylation | BP |
KEGG
Orthology
- This transcript has been annotated with K06619 (abelson tyrosine-protein kinase 1)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
