General information for g7713.t14
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Prostaglandin E synthase 2.
Parent gene
- The parent gene g7713 is located on chr_2: 25417746..25420481 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g7713 | g7713.t14 | TTS | g7713.t14 | 25416427 | 25416427 |
| chr_2 | g7713 | g7713.t14 | isoform | g7713.t14 | 25416502 | 25417746 |
| chr_2 | g7713 | g7713.t14 | exon | g7713.t14.exon1 | 25416502 | 25417533 |
| chr_2 | g7713 | g7713.t14 | cds | g7713.t14.CDS1 | 25416502 | 25417413 |
| chr_2 | g7713 | g7713.t14 | exon | g7713.t14.exon2 | 25417593 | 25417746 |
| chr_2 | g7713 | g7713.t14 | TSS | g7713.t14 | 25417814 | 25417814 |
Sequences
>g7713.t14 Gene=g7713 Length=1186
ATGGCATTTAGATATTTATTTACAAGTGTTACAGGACGGCATGTAACTCGTTTAATTATA
CAACCAAAGAATGTAAATCTAGTGCGAAATTATGCAACAAAGATTGAGCCGAAGAAAAAA
ACTTCATCTTTAAAGCTTCTTTTAATTGGAGTAAGGAGCTATTGGAGGAACAATTGGAGC
TCTCTATTCCTTCTACGATAATATTGGCAAGAAGAAACCCACATCTAAGGATTTATCAGC
TACAATTTTGGATAAAAAGCCGGATGTTTCAATAATGAGAAAAATTATAAATCCTAACGA
TAAAAGTGATCTTGATATTGTGTTATTTCAGTTTCAAACATGTCCATTCTGTTGCAAAGT
GAGATCATTTTTAGATTATTCTGGACTTTCTTATTCAGTTGTTGAAGTTGATGCTGTTCT
TCGTGATAGCATAAAATGGTCTGAATCAAAGAAAGTACCTATTGTACTTGTCAAATCAAA
AAATGGCAAATATGTGCAGTTAAATGATAGTTCAATGATTATATCAGCAATTTCAAGCAT
ATTAGTTGATCCAGCTAAAAATGATATAGCCGAGGTTGTTAAATTTTATCCAGTTACTAA
TTTCACAGACGTCTATGGAACAATTTATGATATTGCAAATAAATATTTTCTAATGTTTCA
AGATAAGAAACCAAAAGAAAGTAAAGAAACTTTCGATGAAGAGAGGCAATGGAGAAGCTG
GGCTGATAATCATTTGGTTCATTTAATTTCACCAAATGTCTATCGTACATATGCAGAGGC
TCGAGAAACATTTGAATGGTTTAGTGAAGTTGGACAATGGAGTGCATATTTTCCTGAGTG
GGAACGAAATTTGATGGTACAAGTTGGTACTTTTGCTATGTGGCTTATTAGCAAACGTCT
AATAAAGAAACATGGCCTCAGTGATGATGTTCGAACTCATTTATATGATGCATGTGATAA
ATGGATGGGTGCACTCGAGAAAAAGCAAACTAAATTTATGGGTGGCAATAAAGAGCCCAA
TCTCGCAGATTTATCAGTTTATGGTGTTCTTTGTAGTATGGAAGGATGTGAAGCTTTTAA
AGATTGTCTAGAAAACACTAAAATTGGATTGTGGTTTTATGAAGTTAAAGCTAAAGTAGA
AAGTAATCGTGGTTTTAGAAAACCCACAAGTCTTTATGCTGTATGA
>g7713.t14 Gene=g7713 Length=303
MRKIINPNDKSDLDIVLFQFQTCPFCCKVRSFLDYSGLSYSVVEVDAVLRDSIKWSESKK
VPIVLVKSKNGKYVQLNDSSMIISAISSILVDPAKNDIAEVVKFYPVTNFTDVYGTIYDI
ANKYFLMFQDKKPKESKETFDEERQWRSWADNHLVHLISPNVYRTYAEARETFEWFSEVG
QWSAYFPEWERNLMVQVGTFAMWLISKRLIKKHGLSDDVRTHLYDACDKWMGALEKKQTK
FMGGNKEPNLADLSVYGVLCSMEGCEAFKDCLENTKIGLWFYEVKAKVESNRGFRKPTSL
YAV
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 8 | g7713.t14 | CDD | cd03197 | GST_C_mPGES2 | 136 | 290 | 8.80851E-74 |
| 7 | g7713.t14 | Gene3D | G3DSA:3.40.30.10 | Glutaredoxin | 2 | 93 | 1.6E-32 |
| 6 | g7713.t14 | Gene3D | G3DSA:1.20.1050.10 | - | 135 | 293 | 4.7E-60 |
| 2 | g7713.t14 | PANTHER | PTHR12782 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-2 | 7 | 295 | 7.8E-90 |
| 3 | g7713.t14 | PANTHER | PTHR12782:SF5 | PROSTAGLANDIN E SYNTHASE 2 | 7 | 295 | 7.8E-90 |
| 1 | g7713.t14 | Pfam | PF00462 | Glutaredoxin | 15 | 68 | 5.6E-12 |
| 9 | g7713.t14 | ProSitePatterns | PS00195 | Glutaredoxin active site. | 17 | 33 | - |
| 10 | g7713.t14 | ProSiteProfiles | PS51354 | Glutaredoxin domain profile. | 3 | 101 | 11.286 |
| 11 | g7713.t14 | SFLD | SFLDG01203 | Prostaglandin E synthase like.1 | 7 | 293 | 0.0 |
| 12 | g7713.t14 | SFLD | SFLDS00019 | Glutathione Transferase (cytosolic) | 7 | 293 | 0.0 |
| 4 | g7713.t14 | SUPERFAMILY | SSF52833 | Thioredoxin-like | 14 | 92 | 2.15E-15 |
| 5 | g7713.t14 | SUPERFAMILY | SSF47616 | GST C-terminal domain-like | 133 | 288 | 2.38E-47 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0015035 | protein-disulfide reductase activity | MF |
| GO:0009055 | electron transfer activity | MF |
| GO:0050220 | prostaglandin-E synthase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K05309 (microsomal prostaglandin-E synthase 2)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
