General information for g7773.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Myotubularin-related protein 2.
Parent gene
- The parent gene g7773 is located on chr_2: 25897307..25898302 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g7773 | g7773.t1 | isoform | g7773.t1 | 25896343 | 25898302 |
| chr_2 | g7773 | g7773.t1 | exon | g7773.t1.exon1 | 25896343 | 25897004 |
| chr_2 | g7773 | g7773.t1 | cds | g7773.t1.CDS1 | 25896343 | 25897004 |
| chr_2 | g7773 | g7773.t1 | exon | g7773.t1.exon2 | 25897061 | 25897664 |
| chr_2 | g7773 | g7773.t1 | cds | g7773.t1.CDS2 | 25897061 | 25897664 |
| chr_2 | g7773 | g7773.t1 | exon | g7773.t1.exon3 | 25897723 | 25898178 |
| chr_2 | g7773 | g7773.t1 | cds | g7773.t1.CDS3 | 25897723 | 25898178 |
| chr_2 | g7773 | g7773.t1 | exon | g7773.t1.exon4 | 25898246 | 25898302 |
| chr_2 | g7773 | g7773.t1 | cds | g7773.t1.CDS4 | 25898246 | 25898302 |
| chr_2 | g7773 | g7773.t1 | TSS | g7773.t1 | NA | NA |
| chr_2 | g7773 | g7773.t1 | TTS | g7773.t1 | NA | NA |
Sequences
>g7773.t1 Gene=g7773 Length=1779
ATGGACAGTTATACAAAAAAATCAGGATCTACTGATTCATTAAATAATGACACAGTTCTC
CCAAAAGAACTTCCATTTCAATTGCTATCGGGTGAAACATTTCAAGAGAAAAATGAAGTG
TCCTATATTTGTCCATATTTTGGTCCAATTCGAGGAATTCTTTACATAACAAATTATCGT
CTGTATTTTAAATCATCAATTGACAAAGATCCAGTACAACAAAATTTAGATGTAAATTTG
GGCGTTGTATCGAGAATTGAGAAAGTTGGTGGTGCTAGCTCTCGTGGTGAAAACTCATAT
GGTATTGATATTTTATGCAAGGATATGAGAAATTTGAGATTTGCACACAAACAAGAAAAT
CATTCTCGTCGCACAGTTTTTGGAAAACTGCAGAATTTTGCATTCCCTTTAGCAAATAAT
GAAAAGCTCTTTGCGTTCAACTATTCAGAAAAATTTCCTGAGGATGGATGGAATGTTTAT
GAGCCTATTGCTGAATTTCGTCGCATGGGATTAGGAGCAAATTCAAATATTGAATGGCGT
GTAACAAAAGTTAATCAAGCATATGAATTATGTGACAGTTATCCAGCTGTATTAGCAGTT
CCTCGCAGTATTTCTGATGAAGATTTAAAAGCTGTTGCAAACTTCCGTTCAAGAAATCGT
TTGCCAGTATTATCATGGATTCATCCACAATCATTAGCAACTATAACAAGATGCTCACAA
CCTCTGTGTGGAGTAAGTGGAAAAAAGTCATCAGAAGATGAAGGTTATATAAATGCAATA
ATGGAAGCAAATCCCTTATCACATAAACTCATTATCATGGATGCTCGTCCTTCAGCGAAT
GCGGTTGTGAATAAAGCAAAAGGAGGCGGTTATGAATCAGAGAATGACTATCAAAATGTT
GAATTGATTTTCTTAGATATTCACAATATTCATGTAATGCGTGAAAGTTTAAGAAAACTC
AAAGAAATTTGCTTTCCTGCAACTGATGATCAAAAATGGCTTTCATCTGTTGATAATACA
ATGTGGCTTAAGCATATCAAATGTGTACTTGCTGGTGCCATTCGAATTGTTGATCGTATT
GAAAATACTAAAAATTCTGTAGTGGTTCATTGTTCTGATGGATGGGATAGAACTGCACAA
TTGACTGCTTTAGCAATGATTATGTTGGATCCATATTATAGGACAATAAAAGGTTTTGAA
GTGCTAATAGAAAAAGAATGGCTTAGTTTTGGACATAAATTCCAACAACGTATTGGACAT
GGTGACATCAATCATTCAGATGCAGATCGTTCACCAGTTTTTGTTCAATTTATTGACTGT
GTGTGGCAAATTACAAGACAACTGCCAAACTCTTTTGAGTTTAATGAAAATTTCCTCATT
ACAATTCTTGATCATCTATATTCATGTCGATTCGGTACATTTTTATGTAACACAGAACGT
GAGCGGGTAAATGAGGTGAAGAAATATACAGTTTCATTATGGTCATACATAAATGCATCA
CTTGAACTCTACAGAAATCCACTTTATGGTGGATTCGGTAATTCTCCGACTCTACAAACA
GTTTTAAAACCTGTTGCAAGTATGAGACATATAAGATTATGGAAAGGTTATTATTGTCGT
TGGAATCCAACAATGAAAACGCAAGAACCAATTTATCAGCGAACAAGAGAACTCCTTGCA
TTGCAAGATCAATTAAGAAAACAAATTGACGAAATTCTCGAATGTCGCACTGATGGCAAT
CGTACGACTTTATCAAGGCTAGCCTCTCCGTTACATTAA
>g7773.t1 Gene=g7773 Length=592
MDSYTKKSGSTDSLNNDTVLPKELPFQLLSGETFQEKNEVSYICPYFGPIRGILYITNYR
LYFKSSIDKDPVQQNLDVNLGVVSRIEKVGGASSRGENSYGIDILCKDMRNLRFAHKQEN
HSRRTVFGKLQNFAFPLANNEKLFAFNYSEKFPEDGWNVYEPIAEFRRMGLGANSNIEWR
VTKVNQAYELCDSYPAVLAVPRSISDEDLKAVANFRSRNRLPVLSWIHPQSLATITRCSQ
PLCGVSGKKSSEDEGYINAIMEANPLSHKLIIMDARPSANAVVNKAKGGGYESENDYQNV
ELIFLDIHNIHVMRESLRKLKEICFPATDDQKWLSSVDNTMWLKHIKCVLAGAIRIVDRI
ENTKNSVVVHCSDGWDRTAQLTALAMIMLDPYYRTIKGFEVLIEKEWLSFGHKFQQRIGH
GDINHSDADRSPVFVQFIDCVWQITRQLPNSFEFNENFLITILDHLYSCRFGTFLCNTER
ERVNEVKKYTVSLWSYINASLELYRNPLYGGFGNSPTLQTVLKPVASMRHIRLWKGYYCR
WNPTMKTQEPIYQRTRELLALQDQLRKQIDEILECRTDGNRTTLSRLASPLH
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 9 | g7773.t1 | CDD | cd14535 | PTP-MTM1-like | 219 | 467 | 0.0 |
| 8 | g7773.t1 | Gene3D | G3DSA:2.30.29.30 | - | 34 | 134 | 4.0E-41 |
| 7 | g7773.t1 | Gene3D | G3DSA:3.90.190.10 | Protein tyrosine phosphatase superfamily | 313 | 441 | 3.3E-5 |
| 3 | g7773.t1 | PANTHER | PTHR10807:SF42 | MYOTUBULARIN-RELATED PROTEIN 2 | 25 | 590 | 1.8E-270 |
| 4 | g7773.t1 | PANTHER | PTHR10807 | MYOTUBULARIN-RELATED | 25 | 590 | 1.8E-270 |
| 1 | g7773.t1 | Pfam | PF02893 | GRAM domain | 26 | 136 | 5.1E-18 |
| 2 | g7773.t1 | Pfam | PF06602 | Myotubularin-like phosphatase domain | 143 | 482 | 3.9E-153 |
| 10 | g7773.t1 | ProSitePatterns | PS00383 | Tyrosine specific protein phosphatases active site. | 369 | 379 | - |
| 13 | g7773.t1 | ProSiteProfiles | PS51339 | Myotubularin phosphatase domain. | 156 | 538 | 129.661 |
| 11 | g7773.t1 | SMART | SM00568 | gram2001c | 22 | 90 | 1.1E-10 |
| 12 | g7773.t1 | SMART | SM00404 | ptp_7 | 328 | 467 | 1.3E-4 |
| 5 | g7773.t1 | SUPERFAMILY | SSF50729 | PH domain-like | 26 | 148 | 1.84E-36 |
| 6 | g7773.t1 | SUPERFAMILY | SSF52799 | (Phosphotyrosine protein) phosphatases II | 151 | 543 | 1.44E-151 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016311 | dephosphorylation | BP |
| GO:0004725 | protein tyrosine phosphatase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K18081 (myotubularin-related protein 1/2)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
