General information for g7854.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Frizzled.
Parent gene
- The parent gene g7854 is located on chr_2: 26423754..26424291 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g7854 | g7854.t1 | TTS | g7854.t1 | 26421757 | 26421757 |
| chr_2 | g7854 | g7854.t1 | isoform | g7854.t1 | 26421920 | 26424291 |
| chr_2 | g7854 | g7854.t1 | exon | g7854.t1.exon1 | 26421920 | 26422141 |
| chr_2 | g7854 | g7854.t1 | cds | g7854.t1.CDS1 | 26421920 | 26422141 |
| chr_2 | g7854 | g7854.t1 | exon | g7854.t1.exon2 | 26422193 | 26422274 |
| chr_2 | g7854 | g7854.t1 | cds | g7854.t1.CDS2 | 26422193 | 26422274 |
| chr_2 | g7854 | g7854.t1 | exon | g7854.t1.exon3 | 26422329 | 26422566 |
| chr_2 | g7854 | g7854.t1 | cds | g7854.t1.CDS3 | 26422329 | 26422566 |
| chr_2 | g7854 | g7854.t1 | exon | g7854.t1.exon4 | 26422631 | 26422716 |
| chr_2 | g7854 | g7854.t1 | cds | g7854.t1.CDS4 | 26422631 | 26422716 |
| chr_2 | g7854 | g7854.t1 | exon | g7854.t1.exon5 | 26422779 | 26422900 |
| chr_2 | g7854 | g7854.t1 | cds | g7854.t1.CDS5 | 26422779 | 26422900 |
| chr_2 | g7854 | g7854.t1 | exon | g7854.t1.exon6 | 26422963 | 26423157 |
| chr_2 | g7854 | g7854.t1 | cds | g7854.t1.CDS6 | 26422963 | 26423157 |
| chr_2 | g7854 | g7854.t1 | exon | g7854.t1.exon7 | 26423215 | 26423375 |
| chr_2 | g7854 | g7854.t1 | cds | g7854.t1.CDS7 | 26423215 | 26423375 |
| chr_2 | g7854 | g7854.t1 | exon | g7854.t1.exon8 | 26423441 | 26423684 |
| chr_2 | g7854 | g7854.t1 | cds | g7854.t1.CDS8 | 26423441 | 26423684 |
| chr_2 | g7854 | g7854.t1 | exon | g7854.t1.exon9 | 26423750 | 26423935 |
| chr_2 | g7854 | g7854.t1 | cds | g7854.t1.CDS9 | 26423750 | 26423935 |
| chr_2 | g7854 | g7854.t1 | exon | g7854.t1.exon10 | 26424061 | 26424291 |
| chr_2 | g7854 | g7854.t1 | cds | g7854.t1.CDS10 | 26424061 | 26424291 |
| chr_2 | g7854 | g7854.t1 | TSS | g7854.t1 | 26424417 | 26424417 |
Sequences
>g7854.t1 Gene=g7854 Length=1767
ATGTCGAATAATGTAAAGTTTAGTTTGTTAGTTTTATTTCTTAAAGTATTTTTTGTAATA
TCTCAACAATCGAGCGTAGTAATATCAACAGAGTCAAAAACTCGACAGAAGGATTACGAT
CGAATATCAAGTTATAATCAAAAATGCGAGCCAATACAAATTCCGCTTTGCCAAGATATA
CAATTTTATAATCAAACAATTTTTCCAAATCTCCTGAATCATGCACGACAGGACGAAGCA
GCGCTTGAAGTTCATCAATTTATTCCACTTATTAAAATAAATTGTTCTCCCGACCTGAAA
TTATTTTTATGCTCACTTTATGCTCCGATATGTACAATCTTGGATTATCCTATTCCGCCA
TGCAGAAAGTTATGTGAAAGTGCCAGAAATTGTGAAAAAATTATGAGAACATTTGACTTT
CAATGGCCCGAGAATCTCGAATGCTCGAAATTCCCTGAAGACGGTACAAAAGATATTTGC
ATATCACCCAACAACTCAGCACCGTCATCTTCTTCATCACCATCACAAGATTCACATCAA
TTCAGTACACAAATTACATCGCTTGGAAAAGTAGAGCGAAAAAATCAGCATGACTCGCGA
AACGCAACATCTTTTTCACAGCATAAATTTAGAGGATTTATTTGTCCAGTGCAATTGAAA
GCACCTGCCGCACTGGGATATGAGCTAAATATCGGTGGAAAAGTTGTAAAAGATTGTGGA
GCTCCATGCAGCTCTCTATTTTTTGATGACAAAGAAGTCACAATGCTTAGATATTGGATA
AGTTTTTGGGCAATTATATGTGTGGCTTGTTGCTTATTTACTATTCTAACATTTATTATC
GATTCATCGCGATTTCGATATCCAGAACGTCCTATCGTATTTATTGCGATATGCTATTTA
ATAGTTGCGACTGCTTATATTTCGGGATTGAGTGCTGGAAAAAATATTTCATGCCGTGAT
CCATTTGTGCATACAGTGAAGTTGGGACGCTTGCAAATGATTTCAACAATTACTCAGGGT
CATCAAAGCAGTTTGTCATGTACAGTTCTGTTTTTAATGATGTATTTCTGTCTAATGGCT
TCCTTCACTTGGTGGGTGTTTTTCGCATTATCTTGGCTACTTGCGTCAGGCTTTAAATGG
GGTCATGAAGCAATTGAATCGAGAGCACATCTTTTTCATCTTTGTGGATGGGCTTTACCT
GGAATTCAAACAATTTTTGTGCTTGCATTAGGGAAAGTAGAAGGTGACATTTTGTCAGGT
GTTTGCTTCGTTGGAATGTTATCACGTCATTCAATTGCCATATTTTTGCTGATTCCATTG
ACAATCTATCTAGTGATTGGAACACTCTTTTTCTCCGTTGGCTTCGTTGCACTTCTCAAA
ATCCGAACCATGATGAGAAATAAAAATGATGGAACAAGGACTGATAAATTAGAAAAATTG
ATGTATCGGATTGTCTTTTTCAGTATATTGTTTGTCATTCCATCATTCATTTATATTGGA
TGTTTGTTCTATGAGTGGATATATTTTGATGAATGGACTTTACAGTGGAATCGAATGACA
TGTAAGAAATTTTCGATACCATGTCCACCGATGAGCTTAGAAGATGAGAACCGGCCAATA
TTTAGTATTTTTATGCTTAAATATCTTTGCTCAATGCTAGTTGGAATAACTTCAGGCATC
ACATGGTTGTGCTCGAGTAAAACTTTTGCCAGCTGGAAGACGTTTTTCAATAGAATGAAG
GGTCAAAAAACAAGAAATTATGTATAA
>g7854.t1 Gene=g7854 Length=588
MSNNVKFSLLVLFLKVFFVISQQSSVVISTESKTRQKDYDRISSYNQKCEPIQIPLCQDI
QFYNQTIFPNLLNHARQDEAALEVHQFIPLIKINCSPDLKLFLCSLYAPICTILDYPIPP
CRKLCESARNCEKIMRTFDFQWPENLECSKFPEDGTKDICISPNNSAPSSSSSPSQDSHQ
FSTQITSLGKVERKNQHDSRNATSFSQHKFRGFICPVQLKAPAALGYELNIGGKVVKDCG
APCSSLFFDDKEVTMLRYWISFWAIICVACCLFTILTFIIDSSRFRYPERPIVFIAICYL
IVATAYISGLSAGKNISCRDPFVHTVKLGRLQMISTITQGHQSSLSCTVLFLMMYFCLMA
SFTWWVFFALSWLLASGFKWGHEAIESRAHLFHLCGWALPGIQTIFVLALGKVEGDILSG
VCFVGMLSRHSIAIFLLIPLTIYLVIGTLFFSVGFVALLKIRTMMRNKNDGTRTDKLEKL
MYRIVFFSILFVIPSFIYIGCLFYEWIYFDEWTLQWNRMTCKKFSIPCPPMSLEDENRPI
FSIFMLKYLCSMLVGITSGITWLCSSKTFASWKTFFNRMKGQKTRNYV
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 16 | g7854.t1 | Gene3D | G3DSA:1.10.2000.10 | - | 41 | 166 | 1.7E-40 |
| 15 | g7854.t1 | Gene3D | G3DSA:1.20.1070.10 | - | 225 | 582 | 1.6E-115 |
| 3 | g7854.t1 | PANTHER | PTHR11309 | FRIZZLED | 25 | 580 | 3.3E-173 |
| 4 | g7854.t1 | PANTHER | PTHR11309:SF31 | FRIZZLED-7 | 25 | 580 | 3.3E-173 |
| 10 | g7854.t1 | PRINTS | PR00489 | Frizzled protein signature | 259 | 281 | 2.7E-62 |
| 6 | g7854.t1 | PRINTS | PR00489 | Frizzled protein signature | 287 | 309 | 2.7E-62 |
| 5 | g7854.t1 | PRINTS | PR00489 | Frizzled protein signature | 349 | 373 | 2.7E-62 |
| 11 | g7854.t1 | PRINTS | PR00489 | Frizzled protein signature | 392 | 415 | 2.7E-62 |
| 9 | g7854.t1 | PRINTS | PR00489 | Frizzled protein signature | 437 | 459 | 2.7E-62 |
| 7 | g7854.t1 | PRINTS | PR00489 | Frizzled protein signature | 480 | 501 | 2.7E-62 |
| 8 | g7854.t1 | PRINTS | PR00489 | Frizzled protein signature | 543 | 563 | 2.7E-62 |
| 2 | g7854.t1 | Pfam | PF01392 | Fz domain | 49 | 154 | 3.7E-29 |
| 1 | g7854.t1 | Pfam | PF01534 | Frizzled/Smoothened family membrane region | 247 | 578 | 4.0E-111 |
| 25 | g7854.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 29 | - |
| 26 | g7854.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 8 | - |
| 27 | g7854.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 9 | 20 | - |
| 35 | g7854.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 21 | 29 | - |
| 24 | g7854.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 30 | 257 | - |
| 31 | g7854.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 258 | 280 | - |
| 18 | g7854.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 281 | 291 | - |
| 30 | g7854.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 292 | 312 | - |
| 23 | g7854.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 313 | 348 | - |
| 28 | g7854.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 349 | 370 | - |
| 19 | g7854.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 371 | 390 | - |
| 33 | g7854.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 391 | 411 | - |
| 22 | g7854.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 412 | 430 | - |
| 32 | g7854.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 431 | 459 | - |
| 17 | g7854.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 460 | 479 | - |
| 34 | g7854.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 480 | 509 | - |
| 21 | g7854.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 510 | 539 | - |
| 29 | g7854.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 540 | 564 | - |
| 20 | g7854.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 565 | 588 | - |
| 46 | g7854.t1 | ProSiteProfiles | PS50038 | Frizzled (fz) domain profile. | 44 | 163 | 27.265 |
| 45 | g7854.t1 | ProSiteProfiles | PS50261 | G-protein coupled receptors family 2 profile 2. | 256 | 560 | 29.344 |
| 43 | g7854.t1 | SMART | SM00063 | FRI_4 | 48 | 165 | 2.2E-62 |
| 44 | g7854.t1 | SMART | SM01330 | Frizzled_2 | 246 | 582 | 4.6E-151 |
| 12 | g7854.t1 | SUPERFAMILY | SSF63501 | Frizzled cysteine-rich domain | 48 | 163 | 2.35E-38 |
| 14 | g7854.t1 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 21 | - |
| 13 | g7854.t1 | SignalP_GRAM_POSITIVE | SignalP-TM | SignalP-TM | 1 | 29 | - |
| 40 | g7854.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 258 | 280 | - |
| 42 | g7854.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 293 | 312 | - |
| 36 | g7854.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 354 | 376 | - |
| 39 | g7854.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 389 | 411 | - |
| 41 | g7854.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 431 | 459 | - |
| 38 | g7854.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 480 | 502 | - |
| 37 | g7854.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 541 | 563 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016020 | membrane | CC |
| GO:0005515 | protein binding | MF |
| GO:0042813 | Wnt-activated receptor activity | MF |
| GO:0016055 | Wnt signaling pathway | BP |
| GO:0016021 | integral component of membrane | CC |
| GO:0004888 | transmembrane signaling receptor activity | MF |
| GO:0007166 | cell surface receptor signaling pathway | BP |
KEGG
Orthology
- This transcript has been annotated with K02432 (frizzled 1/7)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
