Gene loci information

Transcript annotation

  • This transcript has been annotated as Dual specificity tyrosine-phosphorylation-regulated kinase 2.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_2 g8179 g8179.t1 TSS g8179.t1 28938568 28938568
chr_2 g8179 g8179.t1 isoform g8179.t1 28938783 28942271
chr_2 g8179 g8179.t1 exon g8179.t1.exon1 28938783 28938791
chr_2 g8179 g8179.t1 cds g8179.t1.CDS1 28938783 28938791
chr_2 g8179 g8179.t1 exon g8179.t1.exon2 28938910 28940211
chr_2 g8179 g8179.t1 cds g8179.t1.CDS2 28938910 28940211
chr_2 g8179 g8179.t1 exon g8179.t1.exon3 28940269 28940438
chr_2 g8179 g8179.t1 cds g8179.t1.CDS3 28940269 28940438
chr_2 g8179 g8179.t1 exon g8179.t1.exon4 28940607 28940841
chr_2 g8179 g8179.t1 cds g8179.t1.CDS4 28940607 28940841
chr_2 g8179 g8179.t1 exon g8179.t1.exon5 28940965 28941046
chr_2 g8179 g8179.t1 cds g8179.t1.CDS5 28940965 28941046
chr_2 g8179 g8179.t1 exon g8179.t1.exon6 28941129 28941176
chr_2 g8179 g8179.t1 cds g8179.t1.CDS6 28941129 28941176
chr_2 g8179 g8179.t1 exon g8179.t1.exon7 28941251 28941364
chr_2 g8179 g8179.t1 cds g8179.t1.CDS7 28941251 28941364
chr_2 g8179 g8179.t1 exon g8179.t1.exon8 28941442 28942271
chr_2 g8179 g8179.t1 cds g8179.t1.CDS8 28941442 28942271
chr_2 g8179 g8179.t1 TTS g8179.t1 28942869 28942869

Sequences

>g8179.t1 Gene=g8179 Length=2790
ATGGAAAATAAAATATCACTTATTTGTGAGCCACAGAATGGAAATACGAGTGAAAATAAT
AAGAATAATGAGGGTGGTGTATATTTCTCATCATCATCATCGTCAAATGCATCGACACTC
AAAAAAAGTTCTCGCATTTCCAAACACTCATTTGACAATTTAAATAGTTTACAAAGTACA
CCCAATATGAAAATGATATCAAAAATCAATTCAATATCATCGCTTAACGATAAAAATTTG
GAAAAGTTTTCGCTTGTTGGAAATAATATTAATAATAATAACAACAACAATAGGTTTTTG
GCTACAAAATCATCATACATCGATTCATTCGATTTCTTACCTGGAGGCTCATCTTCCAAT
TCTAACAACTATAATACACTGGACTCGTTGAGCTCGGCAAAAAGTCTCAAATTTAATAAT
AATAGTGATAATTCTTCCGCTTCTGCTGCTGTGTTCTGGGATTTTACAAAGCCTGGCCTC
ATCTCTTCTCTGCCTGCTGCAGCTGCTTCATCCAGCACAAATTTAAGAAATACTGTCTCC
TCATCGAATCTAACACTTAATAATATAAGCTACGCTGATACTCAGACAAACCAATCATCA
TCGTTGTCATCAACAACTGCTGCTGGCTCATCAACGATTCCTTTGGTGGTTCTTCCACAA
AAATTTCAATTTGATATGCCACAAGCACAACCTCAAATGATGAAAGCTGCTAGCAGTGCT
CTTATGCTCGCTAGTGGTAGTGGCCCTTCTTCCTCCTTCTCATCTTCTACAGTAGCAGCA
GCAGCATCAACAGTAGTACAGCAGGATGAACAACAACATCAAATGCAGATGTTTTGTAGT
CGTAAAAATTCGCTACCACATAGTAGTTTAATTAACAATAATCATACGAGTGGTAGTAGC
AACAATGACTTAAATGTAAATGGTGCAAATAAGAGTAATGTAAAACTTTCTGTAACAGCT
GCTTCAAATCATCATCAAAATGGAAATAATCAACCTCAGCAGCAACAACAAAACACCGAT
GCACAGCAGCAGCAGCAACAACAACAGCAAGTGATTTCAAGTAAATCACAAGCAATGAAG
TGTCCTGTTGTAGCATCTCCACAGCAAGTTATGATGTTATATATGAACAAACTGACACCA
TATGAGCATCACGAAATTTACAAATACTCACATATATATTTCATTGGTGCTAATGCTAAA
AAGCGCTCAGGAACGGGTCCGAATGATTTTGATAATGAAAATGGTTCTTATATACATGTA
CCACACGATCATATTGCATATCGTTATGAAGTTCTCAAAATAATTGGCAAGGGAAGCTTT
GGACAAGTATTAAAAGTTTGGTGTCACAAAACTCGTGAACATGTTGCATTAAAAATGGTA
CGAAATGAAAAGAGATTTCATCGACAGGCGCAAGAAGAAATTCGCATTTTAAAGCATTTA
CGTGCACAAGATAAGGAAAATACTTTCAATATAATTCACATGTTCGATTATTTTGTATTT
CGCAATCACATGTGTATAATTTTTGAACTTTTACATATAAATCTCTATGAGTTGATAAAA
AAGAACAAATTTCAAGGCTTTAGTTTACAGCTAGTAAGGAAATTCGCTCACTCCTTACTG
CAATGTTTAGATGCTCTCAATAAGTTTAAGATAATTCATTGCGATTTAAAACCAGAAAAC
ATCTTATTAAAACAGCAAGGTCGTTCCGGAATTAAGGTGATTGATTTTGGCTCATCTTGT
TATGAAAATCAACGTGTATACACTTATATACAATCGAGATTTTATCGAGCTCCAGAAGTG
ATTTTGGGTGGAAAATATGGAATGCCCATTGATATGTGGAGTTTAGGTTGCATTTTGGCA
GAACTTTATACAGGCTTTGCAATATTGCCAGGCGAAGATGAATCAGATCAGCTTGCATGT
ATAATAGAGTTGCTAGGAATGCCACCGAAACAAGTGCTTGAAAATTCTAAACGTGCTAAA
ATATTTTTTAATGCAAAAGGATATCCTCGATATTGTACGACAAAAACCTTAGAGGATGGT
TCAGTCATAATGACAGAAGGTTTTTCACGTCGTGGTATAGTTCGAGGCGCACCGGGCACA
CGAAAATTAAAGAACGCTTTAAATGGATGTGAAGATGTCTATTTTCTACAATTCATCAGC
GAATGTTTAGAATGGACTCCTGAAAAACGACTTACGCCTGAACAGGCATTACATCACTCA
TGGTTCAAAAGGAGATTACCGAAGCTGCCAGGCAATGGAAATAGTAGTAATAGTAGTAGT
AATAATTATAATACCACCAAGCAAACTCATTCGCTAACAACGTCGACTAATACGCTTGCT
GATGGAGGAAAAGATTTGATTGGAGCAACAGCAGTTGGTGGTGGTTCCTCTTCATCAGCG
CTTGTGACAAATAAGGGAATTACTGCAAATTGCTTCTATTATGATAACACTCTACATCAA
TTGAATATTAATCAACATAAAAATCAGCAGCAACACAACGACGAGGCAAAATCATTACCA
GGTAATACATCATTTCATCAGCACATGCACAGTACTGTATCAAAATTGGGTGATAAAGGA
TTTCAATGTGAAAGCTATCAAGATTTGTCTAACCGCAAATCTACAATGACTCTTAATCGT
TTAATGTCTTCATCAATTCATTCTGCATCAACATTATCATTAGTATCTTCATCTCATAAC
AGTACATCTCATAATAATAATAATAATCATAGTGGATCTTCATCTAGCGGCATTTCATCG
TCGAAATTAAATTTACCGCAACTTAATTAA

>g8179.t1 Gene=g8179 Length=929
MENKISLICEPQNGNTSENNKNNEGGVYFSSSSSSNASTLKKSSRISKHSFDNLNSLQST
PNMKMISKINSISSLNDKNLEKFSLVGNNINNNNNNNRFLATKSSYIDSFDFLPGGSSSN
SNNYNTLDSLSSAKSLKFNNNSDNSSASAAVFWDFTKPGLISSLPAAAASSSTNLRNTVS
SSNLTLNNISYADTQTNQSSSLSSTTAAGSSTIPLVVLPQKFQFDMPQAQPQMMKAASSA
LMLASGSGPSSSFSSSTVAAAASTVVQQDEQQHQMQMFCSRKNSLPHSSLINNNHTSGSS
NNDLNVNGANKSNVKLSVTAASNHHQNGNNQPQQQQQNTDAQQQQQQQQQVISSKSQAMK
CPVVASPQQVMMLYMNKLTPYEHHEIYKYSHIYFIGANAKKRSGTGPNDFDNENGSYIHV
PHDHIAYRYEVLKIIGKGSFGQVLKVWCHKTREHVALKMVRNEKRFHRQAQEEIRILKHL
RAQDKENTFNIIHMFDYFVFRNHMCIIFELLHINLYELIKKNKFQGFSLQLVRKFAHSLL
QCLDALNKFKIIHCDLKPENILLKQQGRSGIKVIDFGSSCYENQRVYTYIQSRFYRAPEV
ILGGKYGMPIDMWSLGCILAELYTGFAILPGEDESDQLACIIELLGMPPKQVLENSKRAK
IFFNAKGYPRYCTTKTLEDGSVIMTEGFSRRGIVRGAPGTRKLKNALNGCEDVYFLQFIS
ECLEWTPEKRLTPEQALHHSWFKRRLPKLPGNGNSSNSSSNNYNTTKQTHSLTTSTNTLA
DGGKDLIGATAVGGGSSSSALVTNKGITANCFYYDNTLHQLNINQHKNQQQHNDEAKSLP
GNTSFHQHMHSTVSKLGDKGFQCESYQDLSNRKSTMTLNRLMSSSIHSASTLSLVSSSHN
STSHNNNNNHSGSSSSGISSSKLNLPQLN

Protein features from InterProScan

Transcript Database ID Name Start End E.value
8 g8179.t1 Coils Coil Coil 467 487 -
6 g8179.t1 Gene3D G3DSA:1.10.8.980 - 322 406 1.3E-16
5 g8179.t1 Gene3D G3DSA:3.30.200.20 Phosphorylase Kinase; domain 1 411 510 1.1E-122
7 g8179.t1 Gene3D G3DSA:1.10.510.10 Transferase(Phosphotransferase) domain 1 485 742 1.1E-122
13 g8179.t1 MobiDBLite mobidb-lite consensus disorder prediction 323 358 -
12 g8179.t1 MobiDBLite mobidb-lite consensus disorder prediction 748 773 -
15 g8179.t1 MobiDBLite mobidb-lite consensus disorder prediction 750 773 -
14 g8179.t1 MobiDBLite mobidb-lite consensus disorder prediction 895 929 -
2 g8179.t1 PANTHER PTHR24058 DUAL SPECIFICITY PROTEIN KINASE 281 778 7.9E-238
3 g8179.t1 PANTHER PTHR24058:SF112 DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 3 HOMOLOG-RELATED 281 778 7.9E-238
1 g8179.t1 Pfam PF00069 Protein kinase domain 429 742 3.0E-55
10 g8179.t1 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 435 458 -
9 g8179.t1 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 551 563 -
16 g8179.t1 ProSiteProfiles PS50011 Protein kinase domain profile. 429 742 37.404
11 g8179.t1 SMART SM00220 serkin_6 429 742 1.6E-83
4 g8179.t1 SUPERFAMILY SSF56112 Protein kinase-like (PK-like) 417 750 1.48E-82

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0005524 ATP binding MF
GO:0004672 protein kinase activity MF
GO:0006468 protein phosphorylation BP

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values