General information for g823.t11
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial.
Parent gene
- The parent gene g823 is located on chr_3: 6266468..6270027 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g823 | g823.t11 | isoform | g823.t11 | 6266163 | 6269939 |
| chr_3 | g823 | g823.t11 | exon | g823.t11.exon1 | 6266163 | 6266192 |
| chr_3 | g823 | g823.t11 | cds | g823.t11.CDS1 | 6266163 | 6266192 |
| chr_3 | g823 | g823.t11 | exon | g823.t11.exon2 | 6266299 | 6266366 |
| chr_3 | g823 | g823.t11 | cds | g823.t11.CDS2 | 6266299 | 6266366 |
| chr_3 | g823 | g823.t11 | exon | g823.t11.exon3 | 6266441 | 6266801 |
| chr_3 | g823 | g823.t11 | cds | g823.t11.CDS3 | 6266441 | 6266801 |
| chr_3 | g823 | g823.t11 | exon | g823.t11.exon4 | 6268390 | 6268467 |
| chr_3 | g823 | g823.t11 | cds | g823.t11.CDS4 | 6268390 | 6268419 |
| chr_3 | g823 | g823.t11 | exon | g823.t11.exon5 | 6269929 | 6269939 |
| chr_3 | g823 | g823.t11 | TSS | g823.t11 | 6270055 | 6270055 |
| chr_3 | g823 | g823.t11 | TTS | g823.t11 | NA | NA |
Sequences
>g823.t11 Gene=g823 Length=548
ACTTGTTTATTATTAAAAATTTATCGTCTTAAAAATAATCAACTGATAAAGAATTAATCA
TGTCGCTCTTCAGAATCGCATCAGCGGAGGTACGCAATGTTATCAAGCGCTCATATAACA
CCACAAATGTCGCACCCACTGTCAAAATGTTCATTGATGGAAAATTTGTTGATTCACAAG
CCAAAGAATGGATTGATTTACATGATCCAGCAACAAATGAGCTTGTAACACGCGTTCCAA
AGTGCACTCTTGATGAAATGAATGCTGCTGTTGAATCATCGAAACGCGCTTTTAAGACAT
GGAGTCAAACATCAATTCTTACACGTCAGCAAGTCATGCTCAAATTGCAGCATATTATTC
GCGCCAATATGTCTGAATTAGCTAAGAATATTACAAAAGAACAGGGAAAAACACTTGTCG
ATGCTGAAGGCGATGTTTTAAGAGGATTGCAGGTTGTTGAGCACATGTGCAGCATTACAT
CGCTTCAACAAGGCGAGACGATGCCAAATATTGCAAAGGATATGGATACTTATAGTTATA
CTCTTCCA
>g823.t11 Gene=g823 Length=163
MSLFRIASAEVRNVIKRSYNTTNVAPTVKMFIDGKFVDSQAKEWIDLHDPATNELVTRVP
KCTLDEMNAAVESSKRAFKTWSQTSILTRQQVMLKLQHIIRANMSELAKNITKEQGKTLV
DAEGDVLRGLQVVEHMCSITSLQQGETMPNIAKDMDTYSYTLP
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 5 | g823.t11 | Gene3D | G3DSA:3.40.605.10 | Aldehyde Dehydrogenase; Chain A | 22 | 163 | 0 |
| 2 | g823.t11 | PANTHER | PTHR43866:SF3 | METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL | 9 | 163 | 0 |
| 3 | g823.t11 | PANTHER | PTHR43866 | MALONATE-SEMIALDEHYDE DEHYDROGENASE | 9 | 163 | 0 |
| 1 | g823.t11 | Pfam | PF00171 | Aldehyde dehydrogenase family | 36 | 161 | 0 |
| 4 | g823.t11 | SUPERFAMILY | SSF53720 | ALDH-like | 13 | 162 | 0 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004491 | methylmalonate-semialdehyde dehydrogenase (acylating) activity | MF |
| GO:0055114 | NA | NA |
| GO:0016491 | oxidoreductase activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
