Gene loci information

Transcript annotation

  • This transcript has been annotated as Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_2 g8273 g8273.t4 TSS g8273.t4 29428873 29428873
chr_2 g8273 g8273.t4 isoform g8273.t4 29429047 29431264
chr_2 g8273 g8273.t4 exon g8273.t4.exon1 29429047 29429167
chr_2 g8273 g8273.t4 cds g8273.t4.CDS1 29429047 29429167
chr_2 g8273 g8273.t4 exon g8273.t4.exon2 29429897 29429931
chr_2 g8273 g8273.t4 cds g8273.t4.CDS2 29429897 29429931
chr_2 g8273 g8273.t4 exon g8273.t4.exon3 29429990 29430169
chr_2 g8273 g8273.t4 cds g8273.t4.CDS3 29429990 29430169
chr_2 g8273 g8273.t4 exon g8273.t4.exon4 29430350 29430547
chr_2 g8273 g8273.t4 cds g8273.t4.CDS4 29430350 29430547
chr_2 g8273 g8273.t4 exon g8273.t4.exon5 29430611 29431264
chr_2 g8273 g8273.t4 cds g8273.t4.CDS5 29430611 29431264
chr_2 g8273 g8273.t4 TTS g8273.t4 NA NA

Sequences

>g8273.t4 Gene=g8273 Length=1188
ATGGCTACAGTAGAAAAAATTGATAAAATTGAAAAGATTCAGCCTCACGACGATGTTTCA
ACTTCAAGAGCCTCAGAACAAACTGGAACAACAAAAGAGTCCGAAACAGCATCGGAAAGT
GCGAGAACTGCTGGAGATAGGAGTGCCATAAATGAGACGTTATCAGATGGCACCAGAGGA
AGTGGTGTCAACAGCTCGATGGCTGCAAGGACAGCAAAATCTGACAAAGAAAAGAAAATT
GGTCATCGAAGGGTTGGTGAAGATGGTGAAATCACTTATAAAAAGATCCAAACGAGCACT
ATTATGGGCTCAATTCAATTAGGCATACAACACACGGTTGGAAGTTTAGCCTCCAAACCG
AAACGTGATTTGCTAATGATGGACTTCTGGGAAATGGAAACAATTTCATTTCCGCCTGAA
GGATCAAGTATGACACCCGCTCATCATTATAGTGAATTTAGATTCAAAATTTATGCTCCT
ATCGCCTTCCGGTATTTTCGAGATTTATTTGGAATACAACCAGACGATTTTATGATGTCT
ATGTGTTCAGCACCACTTCGTGAACTCTCAAATCCAGGTGCATCTGGTTCTATATTTTAT
CTCACTGACGACGATGAGTTTATAATCAAAACAGTTCAACATAAAGAGGGAGAATTTTTG
CAAAAACTGCTTCCAGGCTACTATATGAATCTTAATCAAAATCCTCGTACACTATTACCA
AAATTTTTCGGTTTATATTGTTATCAATGTAATAGTAAAAATGTCCGTCTTGTTGCAATG
AATAATTTGTTACCGTCATCAATAAAGCTGCATTTGAAATATGATTTAAAAGGATCAACT
TATAAGCGAAAAGCAAATAAATCTGAACGTCAGAAAAAATCTCCCACTTATAAGGATTTA
GATTTTATGGAACATCATCCGAATGGTATTAGTTTGGAAGCTGACACGTATGCAGCATTG
ATAAAGACAATACAGAGGGATTGTCGTGTGTTAGAATCATTTAAAATTATGGATTATTCA
CTGCTCGTTGGAGTACACAATATGGATCAAGCTCAAAAGGAAAAGCAGGAAGAAAAACTA
AAGAACCCTCGCAAAGATTCACATGGTGATGATTCTGATATGGAAGACGCACCTGAAGCA
GATCAAGCGATGCATGAAGATAGGGCAGGATCTGCATTGAATCGTACA

>g8273.t4 Gene=g8273 Length=396
MATVEKIDKIEKIQPHDDVSTSRASEQTGTTKESETASESARTAGDRSAINETLSDGTRG
SGVNSSMAARTAKSDKEKKIGHRRVGEDGEITYKKIQTSTIMGSIQLGIQHTVGSLASKP
KRDLLMMDFWEMETISFPPEGSSMTPAHHYSEFRFKIYAPIAFRYFRDLFGIQPDDFMMS
MCSAPLRELSNPGASGSIFYLTDDDEFIIKTVQHKEGEFLQKLLPGYYMNLNQNPRTLLP
KFFGLYCYQCNSKNVRLVAMNNLLPSSIKLHLKYDLKGSTYKRKANKSERQKKSPTYKDL
DFMEHHPNGISLEADTYAALIKTIQRDCRVLESFKIMDYSLLVGVHNMDQAQKEKQEEKL
KNPRKDSHGDDSDMEDAPEADQAMHEDRAGSALNRT

Protein features from InterProScan

Transcript Database ID Name Start End E.value
7 g8273.t4 CDD cd17301 PIPKc_PIP5KI 99 347 0.0
6 g8273.t4 Gene3D G3DSA:3.30.800.10 Phosphatidylinositol Phosphate Kinase II Beta 95 262 1.1E-67
5 g8273.t4 Gene3D G3DSA:3.30.810.10 - 263 368 1.1E-33
10 g8273.t4 MobiDBLite mobidb-lite consensus disorder prediction 1 19 -
12 g8273.t4 MobiDBLite mobidb-lite consensus disorder prediction 1 83 -
9 g8273.t4 MobiDBLite mobidb-lite consensus disorder prediction 20 70 -
11 g8273.t4 MobiDBLite mobidb-lite consensus disorder prediction 350 396 -
2 g8273.t4 PANTHER PTHR23086:SF101 LP03320P-RELATED 32 367 8.9E-196
3 g8273.t4 PANTHER PTHR23086 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE 32 367 8.9E-196
1 g8273.t4 Pfam PF01504 Phosphatidylinositol-4-phosphate 5-Kinase 184 382 3.3E-70
13 g8273.t4 ProSiteProfiles PS51455 Phosphatidylinositol phosphate kinase (PIPK) domain profile. 97 396 53.487
8 g8273.t4 SMART SM00330 PIPK_2 125 393 2.5E-94
4 g8273.t4 SUPERFAMILY SSF56104 SAICAR synthase-like 94 371 1.5E-92

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0016307 phosphatidylinositol phosphate kinase activity MF
GO:0046488 phosphatidylinositol metabolic process BP

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values