General information for g8881.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Tyrosine-protein kinase Src42A.
Parent gene
- The parent gene g8881 is located on chr_2: 33683929..33685912 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g8881 | g8881.t1 | TTS | g8881.t1 | 33670788 | 33670788 |
| chr_2 | g8881 | g8881.t1 | isoform | g8881.t1 | 33671630 | 33683929 |
| chr_2 | g8881 | g8881.t1 | exon | g8881.t1.exon1 | 33671630 | 33671728 |
| chr_2 | g8881 | g8881.t1 | cds | g8881.t1.CDS1 | 33671630 | 33671728 |
| chr_2 | g8881 | g8881.t1 | exon | g8881.t1.exon2 | 33671832 | 33671941 |
| chr_2 | g8881 | g8881.t1 | cds | g8881.t1.CDS2 | 33671832 | 33671941 |
| chr_2 | g8881 | g8881.t1 | exon | g8881.t1.exon3 | 33672022 | 33672188 |
| chr_2 | g8881 | g8881.t1 | cds | g8881.t1.CDS3 | 33672022 | 33672188 |
| chr_2 | g8881 | g8881.t1 | exon | g8881.t1.exon4 | 33672320 | 33672342 |
| chr_2 | g8881 | g8881.t1 | cds | g8881.t1.CDS4 | 33672320 | 33672342 |
| chr_2 | g8881 | g8881.t1 | exon | g8881.t1.exon5 | 33672454 | 33672599 |
| chr_2 | g8881 | g8881.t1 | cds | g8881.t1.CDS5 | 33672454 | 33672599 |
| chr_2 | g8881 | g8881.t1 | exon | g8881.t1.exon6 | 33672719 | 33672879 |
| chr_2 | g8881 | g8881.t1 | cds | g8881.t1.CDS6 | 33672719 | 33672879 |
| chr_2 | g8881 | g8881.t1 | exon | g8881.t1.exon7 | 33672945 | 33673111 |
| chr_2 | g8881 | g8881.t1 | cds | g8881.t1.CDS7 | 33672945 | 33673111 |
| chr_2 | g8881 | g8881.t1 | exon | g8881.t1.exon8 | 33674927 | 33675005 |
| chr_2 | g8881 | g8881.t1 | cds | g8881.t1.CDS8 | 33674927 | 33675005 |
| chr_2 | g8881 | g8881.t1 | exon | g8881.t1.exon9 | 33675076 | 33675160 |
| chr_2 | g8881 | g8881.t1 | cds | g8881.t1.CDS9 | 33675076 | 33675160 |
| chr_2 | g8881 | g8881.t1 | exon | g8881.t1.exon10 | 33675228 | 33675349 |
| chr_2 | g8881 | g8881.t1 | cds | g8881.t1.CDS10 | 33675228 | 33675349 |
| chr_2 | g8881 | g8881.t1 | exon | g8881.t1.exon11 | 33681294 | 33683929 |
| chr_2 | g8881 | g8881.t1 | cds | g8881.t1.CDS11 | 33681294 | 33683929 |
| chr_2 | g8881 | g8881.t1 | TSS | g8881.t1 | NA | NA |
Sequences
>g8881.t1 Gene=g8881 Length=3795
ATGTCCACAAGTCTGCCAGTAGTTTGGTGTGCAGATCGAAATTCGGTTGACAATAAGCCG
ACTGCTTTTGCATTGCAAGGTATACATTTGCAAGGAAATATAAGTGAGCAACATGTGCTT
GCTGTACGTGAACTAATAAATGCAGCATCTGAAGGACGACTGCTTTTACCGTGCTTGCCA
GCTGATGGTGGTGTTGTTGTTTTAAGTTGTGGTTCTGGGGTAGGAAGTTTGATAGTAAGC
AGTAATGAGAATGAGCTAAAGGAAACGATTATTACTGCAAAAGACGACAGTGAAAAGAAA
ACTGATGAAGAGCGACCTATTTTCAAGTGCAAATCTAATGAAGTGCTGTACGAGTTTCTA
TGTTGTGCTCGATGCATGAATGAGGGAACAAAGTGCACAAATAGAACTACGCAAAATTCA
AAAATTATTGAAAAATATTTGGATGCAAAAATAAATGCTGGACGTGCGATGAGACGAACT
GGTGGTAATAATAATCATAGACCATTAAAACATCGTCGTCGAACAAATATGAAAAACTCA
TTTAAAAATGAAAAACGTTGCGTAAAGAGATTTCAGTCGTCTACTGCAAATAGCAGCAAC
ATTCCGCTTCCGATTTATGCTACAATAAACAAAAGAGAAAAATCGAAAAATTGCGAACGC
AAGATAGACATGAAAGAATCGACAAATGTAAAATCTGACGCAATAGCGACTACTGCAGTA
GCTACTGTTGATATAGCTCAATTTTCATCAACAATTCATGAATCATTTAGAAAAACAAGT
TTTGATTCAACGTGCACAATAAGTTCAATGGATTCTGGCTTCATTGAAATGCAAAATAAA
ATTGAACAGGCAAAAGGTTTAAAAGCTCAAAAGCTGCCTTTATCAGAGAATGTTGTCCAA
ATTAAAGTCGACCCGCCGAAAAATAAAATAAATCAGCAGCAAGAAGAAGAGGAGTTGGAT
CAAGTTGATAATTCAAAAAATGCAACTACTGCAACGTGGAATCGATTGACAATTCCGCAG
CAGTCACGAAATCGTAGAAAATCATATGAGGAATTTAAGTCGCTATTTTGTGATCAAAAA
ACTTCAACATTGTTGTGTGTGAATGATTCGAAAAGTTTGAGTAAATCTCGTCGTAAGTCA
TATGAAGAATTTAAGTCTGTTACAAATAATGATAATAGTAATATTAATAATAAAACTTGT
GATGAAAAAGAAAATAATTCTAGTGGAAATGAATTGACAAATATGAGTAATTTCTTTAGT
CGTATGAGACGAGGATCAAAAAGACATTCACAAAAGAGTAACTCGATTACATTGAACAAT
AGTAGCATTAACAAAAAGTCAATACAAGAACAGCAACAACGTGATATTGCAGAATTTACT
ATTTATGATATTTTACGTAAAAATGATAAGAACAACAAATTAGAAATAACAACAGAAAAT
AAAAGAAATTATGATAAAAATCTTGAATTATTTGAAAGTCATTGTGGGACAATATATGAG
CACAACAAAGAAGGCGACAAAAAGTATGATAAGTATATGACATACGGAACACTCTATGAA
ATTCTACATAGGAAGAGCGATGAAGGTGATTTGTTTGATCGTAAACGAACTTTCTCGGAA
AAATACTCAAATAAGCAACGAATTAATTATGATATTATCAAGTCATCAAAAGCAACTACT
GCTGAAAAAGCGACAACAATTGAAAATACTAATCGACTGCTCAAAATAAAGTTTAATAGT
AATAACAGCAACTCTAATGTCACTGACATGCACGAAGAAAATTTAAATTCATCAAGCACA
AGTGCTTCAATGAAACAAGGAAGTTGCAGTGCGAATAATAATAATAATCAATTATCAATA
ACATCAGTTAATGGCAACAAGCAGTTGTCAACTATTTACGATATTTTACAAACGAAGAAA
TTAGAGACAAATATATCAACGATTCAACCAAATAAAAATCGTTTCTTGGTTCGTAAAATT
ACTGAGGAAGAACTTTTTGAGTTTCAAAAGGAAACTGATGAAAGCACAACAAACACAAGT
GCTTGTAATAACAATGAATTAGACAATCTTATGTCTACTACTACTGCCAGTGCTAATGAC
TCAACAAATGCGGATGAAATAAGTGCCAGTAGCGATCACTCGAAGAGACAAACGAAATTG
CGTCGATTCTCTAATATTTTATCATATTCTCCGAAAGCACTTCATGAGCATGATTTGATG
AAAACACTCGACACGACTACAACTATTGATGAAATTAAAGCTGAATTGAAAATTGACGAA
ATTTATTCGCGTTTAAATCGAACAACAAATGGCAACAATGAAGCGACATGTGCCGATCAC
TTTCAACCACAATTAAATAATTCTCACCAACAGCAACAGCATCATCATCATCATCAACAA
CAGCAACAATTGTTATCAACACAGCATCAAATTTCAATTAAAAATAATGGATCAATTTAC
AAGAGCAATTCACTCGATATGCTCGCAACGACAGAAGAAAATCAAGAATTTTCTATTAAA
CAGAAGCCATTTCGTAAAATATCAGTTCCGGCTCATTTGCCACCAAAAGTTCTACCCAAG
AAAAGCACGAGGCGTCTGTCAGAATTTACTCGTGGAGAATTTCTAAATGAAAAATCATGG
TATTTCCGTAAAATAAAGAGAATAGAAGCAGAAAAGAAGCTGCTTTTGCCTGAAAATGAG
CATGGCGCTTTCTTGATTCGCGATTCTGAGAGCCGTCACAATGATTATTCATTATCAGTA
AGAGATGGAGATACCGTAAAACATTACAGAATCCGTCAGCTTGATGAAGGAGGCTTCTTT
ATAGCGCGTCGTACAACATTTAGAACACTTCAAGAACTTGTGGAACATTATTCAAAAGAT
TCTGATGGTTTATGTGTGAATCTCTGCAAACCATGTGTCCAGATTGAGAAGCCAGTCACC
GATGGATTGTCACATCGCACACGTGATCAATGGGAAATTGATAGAAATTCATTGAGATTT
GTAAAGAAACTCGGATCTGGTCAATTCGGTGATGTATGGGAAGGATTATGGAATAATACG
ACGCCAGTCGCTATCAAAACTCTCAAGCCAAATTCAATGGATGCTAAGGATTTCCTGGCA
GAAGCACAAATCATGAAGAAATTAAGGCACAGTAAGTTGATTCAGTTGTATGCTGTTTGT
ACGCTAGAGGAGCCAATTTACATCATCACTGAATTAATGAAACACGGATCATTGTTGGAG
TATCTGCAAGGCAAAGGACGAAATCTAAAACTTCCACAATTAATCGATATGGCTGCACAA
ATAGCTGCTGGAATGGCATACTTAGAATCACAAAACTATATACATCGTGATTTGGCGGCG
AGAAACGTTCTTGTTGGAGATAATAATATCTGCAAGATTGCCGATTTTGGTTTAGCTAGA
TTAATTAAAGAAGATGAATATGAAGCTCGTGTTGGTGCGAGATTCCCAATAAAATGGACC
GCCCCTGAAGCTGCAAATTACAGTCGATTCTCAATTAAATCTGACGTATGGAGCTTTGGT
ATATTGCTTACAGAATTAGTGACATATGGTCGATTACCTTATCCAGGTATGACAAATGCC
GAAGTACTCAGTCAAGTTGAGCACGGTTATAGAATGCCAATGCCACCTAACTGCACACCT
GCGTTATATGAAATTATGCTTGAATGCTGGCATAAGGATCCAATGAGAAGACCAACATTC
GAAACATTGCAATGGAAGCTTGAAGATTTCTTCACTATGGACCAAAGTGATTATAAAGAA
GCACAACCATATTGA
>g8881.t1 Gene=g8881 Length=1264
MSTSLPVVWCADRNSVDNKPTAFALQGIHLQGNISEQHVLAVRELINAASEGRLLLPCLP
ADGGVVVLSCGSGVGSLIVSSNENELKETIITAKDDSEKKTDEERPIFKCKSNEVLYEFL
CCARCMNEGTKCTNRTTQNSKIIEKYLDAKINAGRAMRRTGGNNNHRPLKHRRRTNMKNS
FKNEKRCVKRFQSSTANSSNIPLPIYATINKREKSKNCERKIDMKESTNVKSDAIATTAV
ATVDIAQFSSTIHESFRKTSFDSTCTISSMDSGFIEMQNKIEQAKGLKAQKLPLSENVVQ
IKVDPPKNKINQQQEEEELDQVDNSKNATTATWNRLTIPQQSRNRRKSYEEFKSLFCDQK
TSTLLCVNDSKSLSKSRRKSYEEFKSVTNNDNSNINNKTCDEKENNSSGNELTNMSNFFS
RMRRGSKRHSQKSNSITLNNSSINKKSIQEQQQRDIAEFTIYDILRKNDKNNKLEITTEN
KRNYDKNLELFESHCGTIYEHNKEGDKKYDKYMTYGTLYEILHRKSDEGDLFDRKRTFSE
KYSNKQRINYDIIKSSKATTAEKATTIENTNRLLKIKFNSNNSNSNVTDMHEENLNSSST
SASMKQGSCSANNNNNQLSITSVNGNKQLSTIYDILQTKKLETNISTIQPNKNRFLVRKI
TEEELFEFQKETDESTTNTSACNNNELDNLMSTTTASANDSTNADEISASSDHSKRQTKL
RRFSNILSYSPKALHEHDLMKTLDTTTTIDEIKAELKIDEIYSRLNRTTNGNNEATCADH
FQPQLNNSHQQQQHHHHHQQQQQLLSTQHQISIKNNGSIYKSNSLDMLATTEENQEFSIK
QKPFRKISVPAHLPPKVLPKKSTRRLSEFTRGEFLNEKSWYFRKIKRIEAEKKLLLPENE
HGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKD
SDGLCVNLCKPCVQIEKPVTDGLSHRTRDQWEIDRNSLRFVKKLGSGQFGDVWEGLWNNT
TPVAIKTLKPNSMDAKDFLAEAQIMKKLRHSKLIQLYAVCTLEEPIYIITELMKHGSLLE
YLQGKGRNLKLPQLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDNNICKIADFGLAR
LIKEDEYEARVGARFPIKWTAPEAANYSRFSIKSDVWSFGILLTELVTYGRLPYPGMTNA
EVLSQVEHGYRMPMPPNCTPALYEIMLECWHKDPMRRPTFETLQWKLEDFFTMDQSDYKE
AQPY
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 20 | g8881.t1 | CDD | cd10370 | SH2_Src_Src42 | 880 | 971 | 9.30114E-63 |
| 21 | g8881.t1 | CDD | cd05068 | PTKc_Frk_like | 989 | 1254 | 0.0 |
| 19 | g8881.t1 | Coils | Coil | Coil | 467 | 487 | - |
| 18 | g8881.t1 | Gene3D | G3DSA:3.30.505.10 | SHC Adaptor Protein | 867 | 987 | 7.2E-37 |
| 17 | g8881.t1 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 991 | 1253 | 4.7E-94 |
| 26 | g8881.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 424 | 450 | - |
| 28 | g8881.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 431 | 450 | - |
| 29 | g8881.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 696 | 718 | - |
| 27 | g8881.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 786 | 806 | - |
| 3 | g8881.t1 | PANTHER | PTHR24418 | TYROSINE-PROTEIN KINASE | 871 | 1261 | 6.8E-197 |
| 4 | g8881.t1 | PANTHER | PTHR24418:SF419 | TYROSINE-PROTEIN KINASE FRK | 871 | 1261 | 6.8E-197 |
| 6 | g8881.t1 | PRINTS | PR00401 | SH2 domain signature | 880 | 894 | 5.7E-17 |
| 7 | g8881.t1 | PRINTS | PR00401 | SH2 domain signature | 901 | 911 | 5.7E-17 |
| 9 | g8881.t1 | PRINTS | PR00401 | SH2 domain signature | 913 | 924 | 5.7E-17 |
| 5 | g8881.t1 | PRINTS | PR00401 | SH2 domain signature | 925 | 935 | 5.7E-17 |
| 8 | g8881.t1 | PRINTS | PR00401 | SH2 domain signature | 946 | 960 | 5.7E-17 |
| 13 | g8881.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 1070 | 1083 | 7.1E-36 |
| 14 | g8881.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 1107 | 1125 | 7.1E-36 |
| 11 | g8881.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 1155 | 1165 | 7.1E-36 |
| 10 | g8881.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 1174 | 1196 | 7.1E-36 |
| 12 | g8881.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 1218 | 1240 | 7.1E-36 |
| 1 | g8881.t1 | Pfam | PF00017 | SH2 domain | 880 | 957 | 1.2E-25 |
| 2 | g8881.t1 | Pfam | PF07714 | Protein tyrosine and serine/threonine kinase | 998 | 1246 | 8.7E-98 |
| 25 | g8881.t1 | ProSitePatterns | PS00107 | Protein kinases ATP-binding region signature. | 1004 | 1026 | - |
| 24 | g8881.t1 | ProSitePatterns | PS00109 | Tyrosine protein kinases specific active-site signature. | 1113 | 1125 | - |
| 30 | g8881.t1 | ProSiteProfiles | PS50001 | Src homology 2 (SH2) domain profile. | 880 | 972 | 25.412 |
| 31 | g8881.t1 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 998 | 1251 | 42.803 |
| 23 | g8881.t1 | SMART | SM00252 | SH2_5 | 878 | 963 | 4.2E-36 |
| 22 | g8881.t1 | SMART | SM00219 | tyrkin_6 | 998 | 1247 | 1.3E-144 |
| 16 | g8881.t1 | SUPERFAMILY | SSF55550 | SH2 domain | 876 | 1018 | 4.58E-41 |
| 15 | g8881.t1 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 985 | 1252 | 4.37E-84 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004713 | protein tyrosine kinase activity | MF |
| GO:0005524 | ATP binding | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0006468 | protein phosphorylation | BP |
KEGG
Orthology
- This transcript has been annotated with K08892 (fyn-related kinase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
