Gene loci information

Transcript annotation

  • This transcript has been annotated as Probable multidrug resistance-associated protein lethal(2)03659.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_2 g8918 g8918.t1 TSS g8918.t1 33804011 33804011
chr_2 g8918 g8918.t1 isoform g8918.t1 33804724 33809190
chr_2 g8918 g8918.t1 exon g8918.t1.exon1 33804724 33804803
chr_2 g8918 g8918.t1 cds g8918.t1.CDS1 33804724 33804803
chr_2 g8918 g8918.t1 exon g8918.t1.exon2 33804866 33805539
chr_2 g8918 g8918.t1 cds g8918.t1.CDS2 33804866 33805539
chr_2 g8918 g8918.t1 exon g8918.t1.exon3 33805600 33805679
chr_2 g8918 g8918.t1 cds g8918.t1.CDS3 33805600 33805679
chr_2 g8918 g8918.t1 exon g8918.t1.exon4 33805742 33805911
chr_2 g8918 g8918.t1 cds g8918.t1.CDS4 33805742 33805911
chr_2 g8918 g8918.t1 exon g8918.t1.exon5 33805968 33808086
chr_2 g8918 g8918.t1 cds g8918.t1.CDS5 33805968 33808086
chr_2 g8918 g8918.t1 exon g8918.t1.exon6 33808144 33808408
chr_2 g8918 g8918.t1 cds g8918.t1.CDS6 33808144 33808408
chr_2 g8918 g8918.t1 exon g8918.t1.exon7 33808463 33809106
chr_2 g8918 g8918.t1 cds g8918.t1.CDS7 33808463 33809106
chr_2 g8918 g8918.t1 exon g8918.t1.exon8 33809164 33809190
chr_2 g8918 g8918.t1 cds g8918.t1.CDS8 33809164 33809190
chr_2 g8918 g8918.t1 TTS g8918.t1 NA NA

Sequences

>g8918.t1 Gene=g8918 Length=4059
ATGGAGTCAAATTCAAAACAACAAAATTTACCAAAACATCCAAGAGAAAATGGAAGCGTG
TTTTCATATTTAACATTTAGTTGGGTATTGCCGTTGTTGCTAAAAGGAAGAAAGAAAACT
TTAGAATTAGAGGACTTGTATCAACCTCTTTCACAACATTTGGCAGCAAATTTAGGAACA
AAATTGGAAAAATCATGGAAAAATGAAGTAAATTCAAAGCGATCAAAAAATAAAAATCCA
AGTTTGATGCGTGCGGGCTTAAAAGTTTTTGGTCCTAATTTAATGTCACATGGATTTTTT
CTTTTATTAATTGAAATGTGTTTCAAAGTCACAATGCCCCTTCTGCTTGGTGGTATATTG
CGGTATTATGGAAATCCAAACAATTCGGATCCTAAAATTGCTTATTTTTATGCTGGCGGG
TTGATTTTGTGCAGCTTTCTTAATGTCATTTGTGCACATGGTTTGATGCTGAGTAATTTG
AATGTTGGAATGAAGATGCGAGTTTCAGCTTGTTCATTGATATATCGAAAATCTTTACGT
CTCAGTAAATCAGCATTACTTAATACAACGAGTGGTCAAGTTGTTAATTTGCTTTCTAAT
GATGTTGGACGATTCGAACTTATTGCTATGTTTGTGCATTATTTATGGGTTGGTCCAATT
GAAACAATTGTGATAGGAGTATTGATGTATATGGAAATTGGAATATCTGCTATAGCTGGT
ATTCTCTTCTTATTGCTCTTTATTCCATTTCAATTCTATCTTGGAAAAAAAACATCGCAA
CTTCGTTTAAGAGTAGCTCTTAGGACTGATGAGAGAGTAAGGTTGATGAATGAGATCATT
CAAGGTATACAAGTTATTAAAATGTACGCTTGGGAAAAACCTTTCGCCAAAGTCGTCTCG
ATGGCTCGTGGTAGAGAAATTCGTGCAATTAGATTTGCATCATGGATACGTGGAATTTTA
CTCTCATTCATTATGTTCAGTTCCCGTGTGTCAATTTTTACAAGTCTTGTGATGTTTGCG
TTGCTCGGCTACACATTAACTGCACAACAAGCATTTGCAGTAACTGCCTATTATAATGTA
TTAAGACAAACAATGACAGTTTTCTTTCCTCAAGCAATTGGTTTTCTTGCAGAAACAATT
GTTAGTGTAAAGAGATTGGAAAAGTTTATGCTCTATGAGGAACTTGATCGTGATTTTCAA
AATACTTCAAAAATGAGTGAAAATGAGAAGCAACCACATGAAAATGGTCACATAAAAGAA
AAATTAAAAAATGTTCAAGAACCCGGCATAAATATGGAAAAAGTGTCTGCAAAATGGAAA
GGTGAAGCGTCAGATCTAACACTTTCAAATATTAACCTTCGAATTCTGCCACACACTGTA
AATGCGATCATTGGTCGAGTTGGTTCTGGAAAATCAAGTTTAGTTCAAGCAATTTTGGGT
GAATTGTCAATTAATAGCGGTAAAATTGAAGTTAATGGAAAAATATCTTTTGCTTCTCAA
GAGGCTTGGCTTTTCTCAAGTTCTGTACGTCAAAATATTCTTTTTGGTTTACCAATGAAT
AAAGTTCGATATCGTGCAGTTGTTAAAGCATGCTCACTAACAAGAGATTTTGAACTATGG
CCCGATGGTGATAAAACAATAGTTGGTGAGCGTGGAATGAGCTTAAGTGGAGGTCAAAAG
GCAAGAATTAATTTAGCTAGATCTGTCTATAGAGAAGCTGACATTTATTTGTTAGATGAT
CAGTTAAGCGCAGTAGATTCGCATGTACAAAGGCATTTGTTTGAAAATTGTATAAAAGGT
TTTCTCAAAGATAAAATCGTAATTTTTGTAACTCATCAACTTTATTACTTGCCAAATGTT
GATCAAATAATATTACTTGATAATGGTAAAGTTCAAGCAAATGGAACTTATGAAAGTTTG
AGAGATACAGGATTAGATTTTACAAAACTTTTACCAGAAGAGGAGGATAAAAAAGCAGAA
AATAATGATGATGATTCAATCTCATATCAAAGACAATTTAGTCGATCTAGCAGTAATACA
AGTAGAGACAGTAAATCAACAAATCAACGACATAATAGTGTCTCTTCACGTGATTCTATT
GAAACAGAAATCAGCACAACTGAGAGAATGCAAGTTGAAGAAAAAAGTTCTGAAGGATCA
ATTAGTTGGAGACATTACAAAGCATACATAAAAGGAACAGGAGGTTACACAACTACTTTA
TTCATTGCATTCATGTTTATTCTTGCACAAGTATTTGCAAGTGCTGGTGATTATTTTTTA
ACTTATTGGGTATCAAAAGAGGAAGAGAGAAGCATTACTGAGTTAACATCATCTCTAAAT
GAAACAGTGCCAACATTCGAAAAAATTGTTCAACAATCTAATGATTCATTCATTGAAACA
GCAAAATATATCTTTGAAGGAGTCGTATATGATAGAAACATTGATATTTACATATTCAGC
GCATTGACAGTTGGTTGTGTAATTATTACATTAAGCAGAAGTTTCATGTTCTTTAATGTG
ACAATGAAAGCAAGTCGTCGTTTACATGATGCAATGTTTTCAGGAATAAGTCATGCGACA
ATGTACTTTTTCAATACAAATCCTTCAGGAAGAATCTTGAATAGATTTAGCAAAGATATA
GGACAAATAGATGAAGTTCTTCCAATGACAATTGTCGATGTTTTACAGATCTTTTTATCA
CTCTCGGGAATTATAATAGTCGTTGCAATTGTCAATCCATACACTTTGATTCCTACATTT
TTCATTGCAATTCTATTCTATTTCATGAGAAGTTTTTATTTAAAATCAAGCAGGAATATA
AAAAGAATAGATGCAACAACAAGATCCCCAATTTTCTCACATCTCTCTGCAACATTAAAT
GGTTTATCAACAATTCGAGCTTTTAATGCTGAAGAGATTTTAACAAAAGAATTTGATTCT
CATCAAGATTTAAATAGCACTGCATTTTATTTGTTTTTGGGATCTTCAAGAGCTTTCGGT
TTTTGGTTAGATTTTACGCTTTGCATCTATATTGCTCTTGTCATTTTAAGCTTCTTTATA
ATGGGCAATTCCGGTGGAAATGTTGGCTTAGCAATCACTCAAGTAATGGGTTTAACTGGA
ATGCTTCAATGGGGTTTACGTCAATCAGCCGAGCTTGAAAATAATATGACAGCCGTTGAA
CGAGTTGTTGAGTACCAGTCAGTAGATCCTGAACCAGATTTTGAGTCGAAACCTGATAAA
AAACCACCAAAAGAATGGCCAGAAAAGGGTCAAATTAAATTCAATAAATTGTCATTGAGT
TACTATCCTGATATGAAAGATAAAGTTTTAAAAGAACTTGAATTTGAAATCAAACCACAA
GAGAAAATTGGTGTGGTAGGCCGAACAGGTGCTGGTAAAAGTTCAATCATCAATGCTTTA
TTCAGATTGTCATATTTAGATGGAAAAATTGAAATCGATTTAAGAGATACACAACAAATA
GGACTTCATGATTTAAGATCAAAAATTTCAATTATTCCTCAAGAACCAGTTTTATTTTCA
AACACTATTCGCTACAATCTTGATCCATTTGATGAATTCGCCGATGATAAATTGTGGAGT
GCACTTGAAGAAGTAAATTTAAAAACACCTATTAAAGAAATGCCAGCAGGATTGAACACA
AAAATTACAGAAGGAGGAACAAATTTCTCTGTCGGTCAAAGGCAACTTGTTTGCTTAGCT
CGTGCCATTTTGAGAGAAAATAAAATTCTTGTGATGGATGAAGCAACAGCAAATGTAGAT
TTAGAGACAGATGCATTAATTCAAACGACAATAAGAAATAAATTTGCTGACTGTACTTTA
ATCACTATAGCTCATAGACTTAATACAATTATGGATAGTGATAGAATATTGGTAATGGAT
GCTGGAAAATGTGTTGAATTTTCATCACCTTATGAGTTGTTAATAAAGAAAGAAGAACCA
AGAGTTTTTTACAAAATGCTAAAAGAAACTCCAAAAACAACTTTTGATATGCTAAAAAAG
ATTGCAGAAGAGACTTATAAAAAGAAAAAGACAGAATAA

>g8918.t1 Gene=g8918 Length=1352
MESNSKQQNLPKHPRENGSVFSYLTFSWVLPLLLKGRKKTLELEDLYQPLSQHLAANLGT
KLEKSWKNEVNSKRSKNKNPSLMRAGLKVFGPNLMSHGFFLLLIEMCFKVTMPLLLGGIL
RYYGNPNNSDPKIAYFYAGGLILCSFLNVICAHGLMLSNLNVGMKMRVSACSLIYRKSLR
LSKSALLNTTSGQVVNLLSNDVGRFELIAMFVHYLWVGPIETIVIGVLMYMEIGISAIAG
ILFLLLFIPFQFYLGKKTSQLRLRVALRTDERVRLMNEIIQGIQVIKMYAWEKPFAKVVS
MARGREIRAIRFASWIRGILLSFIMFSSRVSIFTSLVMFALLGYTLTAQQAFAVTAYYNV
LRQTMTVFFPQAIGFLAETIVSVKRLEKFMLYEELDRDFQNTSKMSENEKQPHENGHIKE
KLKNVQEPGINMEKVSAKWKGEASDLTLSNINLRILPHTVNAIIGRVGSGKSSLVQAILG
ELSINSGKIEVNGKISFASQEAWLFSSSVRQNILFGLPMNKVRYRAVVKACSLTRDFELW
PDGDKTIVGERGMSLSGGQKARINLARSVYREADIYLLDDQLSAVDSHVQRHLFENCIKG
FLKDKIVIFVTHQLYYLPNVDQIILLDNGKVQANGTYESLRDTGLDFTKLLPEEEDKKAE
NNDDDSISYQRQFSRSSSNTSRDSKSTNQRHNSVSSRDSIETEISTTERMQVEEKSSEGS
ISWRHYKAYIKGTGGYTTTLFIAFMFILAQVFASAGDYFLTYWVSKEEERSITELTSSLN
ETVPTFEKIVQQSNDSFIETAKYIFEGVVYDRNIDIYIFSALTVGCVIITLSRSFMFFNV
TMKASRRLHDAMFSGISHATMYFFNTNPSGRILNRFSKDIGQIDEVLPMTIVDVLQIFLS
LSGIIIVVAIVNPYTLIPTFFIAILFYFMRSFYLKSSRNIKRIDATTRSPIFSHLSATLN
GLSTIRAFNAEEILTKEFDSHQDLNSTAFYLFLGSSRAFGFWLDFTLCIYIALVILSFFI
MGNSGGNVGLAITQVMGLTGMLQWGLRQSAELENNMTAVERVVEYQSVDPEPDFESKPDK
KPPKEWPEKGQIKFNKLSLSYYPDMKDKVLKELEFEIKPQEKIGVVGRTGAGKSSIINAL
FRLSYLDGKIEIDLRDTQQIGLHDLRSKISIIPQEPVLFSNTIRYNLDPFDEFADDKLWS
ALEEVNLKTPIKEMPAGLNTKITEGGTNFSVGQRQLVCLARAILRENKILVMDEATANVD
LETDALIQTTIRNKFADCTLITIAHRLNTIMDSDRILVMDAGKCVEFSSPYELLIKKEEP
RVFYKMLKETPKTTFDMLKKIAEETYKKKKTE

Protein features from InterProScan

Transcript Database ID Name Start End E.value
42 g8918.t1 CDD cd18579 ABC_6TM_ABCC_D1 98 386 2.17625E-109
44 g8918.t1 CDD cd03250 ABCC_MRP_domain1 430 630 5.66601E-104
43 g8918.t1 CDD cd03244 ABCC_MRP_domain2 1090 1310 4.29026E-124
14 g8918.t1 Gene3D G3DSA:1.20.1560.10 - 62 396 1.1E-17
12 g8918.t1 Gene3D G3DSA:3.40.50.300 - 397 679 5.4E-75
13 g8918.t1 Gene3D G3DSA:1.20.1560.10 - 707 1073 1.1E-37
11 g8918.t1 Gene3D G3DSA:3.40.50.300 - 1075 1328 8.9E-83
61 g8918.t1 MobiDBLite mobidb-lite consensus disorder prediction 653 715 -
60 g8918.t1 MobiDBLite mobidb-lite consensus disorder prediction 666 701 -
5 g8918.t1 PANTHER PTHR24223:SF360 MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659-LIKE PROTEIN-RELATED 7 1345 0.0
6 g8918.t1 PANTHER PTHR24223 ATP-BINDING CASSETTE SUB-FAMILY C 7 1345 0.0
1 g8918.t1 Pfam PF00664 ABC transporter transmembrane region 98 365 1.2E-27
4 g8918.t1 Pfam PF00005 ABC transporter 448 580 2.5E-18
2 g8918.t1 Pfam PF00664 ABC transporter transmembrane region 741 1039 5.2E-33
3 g8918.t1 Pfam PF00005 ABC transporter 1110 1257 9.5E-29
23 g8918.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 1 19 -
32 g8918.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 20 36 -
21 g8918.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 37 97 -
33 g8918.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 98 123 -
22 g8918.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 124 134 -
41 g8918.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 135 157 -
20 g8918.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 158 206 -
31 g8918.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 207 229 -
27 g8918.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 230 234 -
36 g8918.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 235 254 -
18 g8918.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 255 317 -
37 g8918.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 318 344 -
26 g8918.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 345 363 -
38 g8918.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 364 383 -
15 g8918.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 384 733 -
35 g8918.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 734 753 -
25 g8918.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 754 815 -
40 g8918.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 816 838 -
17 g8918.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 839 885 -
29 g8918.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 886 910 -
24 g8918.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 911 915 -
34 g8918.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 916 933 -
16 g8918.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 934 1000 -
30 g8918.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 1001 1022 -
28 g8918.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 1023 1027 -
39 g8918.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 1028 1046 -
19 g8918.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 1047 1352 -
59 g8918.t1 ProSitePatterns PS00211 ABC transporters family signature. 555 569 -
58 g8918.t1 ProSitePatterns PS00211 ABC transporters family signature. 1229 1243 -
63 g8918.t1 ProSiteProfiles PS50929 ABC transporter integral membrane type-1 fused domain profile. 98 377 33.638
65 g8918.t1 ProSiteProfiles PS50893 ATP-binding cassette, ABC transporter-type domain profile. 430 653 20.962
62 g8918.t1 ProSiteProfiles PS50929 ABC transporter integral membrane type-1 fused domain profile. 740 1054 32.7
64 g8918.t1 ProSiteProfiles PS50893 ATP-binding cassette, ABC transporter-type domain profile. 1092 1326 15.82
56 g8918.t1 SMART SM00382 AAA_5 457 630 9.9E-6
57 g8918.t1 SMART SM00382 AAA_5 1119 1303 1.2E-11
7 g8918.t1 SUPERFAMILY SSF90123 ABC transporter transmembrane region 95 390 7.19E-34
10 g8918.t1 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases 426 650 3.28E-54
8 g8918.t1 SUPERFAMILY SSF90123 ABC transporter transmembrane region 811 1071 1.57E-51
9 g8918.t1 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases 1082 1317 8.04E-67
52 g8918.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 98 120 -
55 g8918.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 135 157 -
47 g8918.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 207 229 -
51 g8918.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 233 255 -
50 g8918.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 318 340 -
46 g8918.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 360 382 -
49 g8918.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 732 754 -
53 g8918.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 816 838 -
54 g8918.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 894 911 -
45 g8918.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 915 934 -
48 g8918.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 998 1020 -

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0055085 transmembrane transport BP
GO:0005524 ATP binding MF
GO:0042626 ATPase-coupled transmembrane transporter activity MF
GO:0016021 integral component of membrane CC
GO:0016887 ATP hydrolysis activity MF

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values