General information for g943.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Pancreatic triacylglycerol lipase .
Parent gene
- The parent gene g943 is located on chr_3: 6992591..6994803 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g943 | g943.t1 | TTS | g943.t1 | 6988416 | 6988416 |
| chr_3 | g943 | g943.t1 | isoform | g943.t1 | 6988690 | 6992816 |
| chr_3 | g943 | g943.t1 | exon | g943.t1.exon1 | 6988690 | 6988804 |
| chr_3 | g943 | g943.t1 | cds | g943.t1.CDS1 | 6988690 | 6988804 |
| chr_3 | g943 | g943.t1 | exon | g943.t1.exon2 | 6988869 | 6989417 |
| chr_3 | g943 | g943.t1 | cds | g943.t1.CDS2 | 6988869 | 6989417 |
| chr_3 | g943 | g943.t1 | exon | g943.t1.exon3 | 6989474 | 6989824 |
| chr_3 | g943 | g943.t1 | cds | g943.t1.CDS3 | 6989474 | 6989824 |
| chr_3 | g943 | g943.t1 | exon | g943.t1.exon4 | 6989898 | 6989931 |
| chr_3 | g943 | g943.t1 | cds | g943.t1.CDS4 | 6989898 | 6989931 |
| chr_3 | g943 | g943.t1 | exon | g943.t1.exon5 | 6990001 | 6990036 |
| chr_3 | g943 | g943.t1 | cds | g943.t1.CDS5 | 6990001 | 6990036 |
| chr_3 | g943 | g943.t1 | exon | g943.t1.exon6 | 6990102 | 6990248 |
| chr_3 | g943 | g943.t1 | cds | g943.t1.CDS6 | 6990102 | 6990248 |
| chr_3 | g943 | g943.t1 | exon | g943.t1.exon7 | 6990338 | 6990386 |
| chr_3 | g943 | g943.t1 | cds | g943.t1.CDS7 | 6990338 | 6990386 |
| chr_3 | g943 | g943.t1 | exon | g943.t1.exon8 | 6990444 | 6990712 |
| chr_3 | g943 | g943.t1 | cds | g943.t1.CDS8 | 6990444 | 6990712 |
| chr_3 | g943 | g943.t1 | exon | g943.t1.exon9 | 6992591 | 6992623 |
| chr_3 | g943 | g943.t1 | cds | g943.t1.CDS9 | 6992591 | 6992623 |
| chr_3 | g943 | g943.t1 | exon | g943.t1.exon10 | 6992696 | 6992816 |
| chr_3 | g943 | g943.t1 | cds | g943.t1.CDS10 | 6992696 | 6992816 |
| chr_3 | g943 | g943.t1 | TSS | g943.t1 | NA | NA |
Sequences
>g943.t1 Gene=g943 Length=1704
ATGTTGAGCTGTGCAGCTTCAATTGTATTAATCATTTTAAATTTGGTATCATTGGCTTTA
TCTGGTCCACTGGATTGGGCTAAGGCAGCAGTTGAATTACCTTGGGCTAGAGCTGATAGA
ATTCCTCTTGATGTTAATCTACCTTGGCTTCCATTTGAAAATGAAACACGATGTTATGGT
GAAATTGGCTGTTTAAATATCACACGTGAATGGTATCATTTAATTCATCGTCCATTTAAT
GTTTTTCCTCTGCCGCGAAATGTCATTAACACGAGATTCATCCTTTATACTGAAGAAAAT
CCTACAGATGGCCAACTGCTCGTGGCCGAAGAGAAAGATACGATTTTAAATTCAAATTTT
CGACCAGATCGACTGACAAAATTTATTATTCACGGATTTATTGACACGCCTTTAAGTACT
TGGGTATCGGAAATGAAAACTGAACTTTTGAAGTATTCGAGCCAAAATCAAGTTATTGTA
GTTGATTGGGGAAGTGGCTCATTGCCTCTTTATACACAGGCAGTGGCTAATACAAGACTG
GTAGGATTAGAATTAGCATACTTAATTAAGAAATTACGTGATGAACATAACTTGAATCCA
GAAGACGTGCATTTAATTGGTCATAGTTTAGGTTCGCATTTGGCTGCATATGCAGCTGAA
AGAGTTCCTGGTATTGGAAGAATAACTGGATTGGATCCTGCAGAACCCATGTTTCAATCA
ATGCCTGAATTTGTTAGACTTGACCCAAGTGATGCAAAATTTGTTGATGTGATTCATACT
GATGCTAGAAGTCTTTTTCTACTAGAGATACCAGGCTATGGAATGTCTCAAGCATGTGGC
CATTTAGATTTCTATCCAAACAATGGAAAAGAAATGCCAGGCTGTTCATTATCTCAAGAG
AGTAGTGCACTTATTCCACTCACTCTCATCAAAGATGGTATCGAAGAAGCTTCTCGTGTT
CTACTCGCATGTAATCATGTGCGTGCTATCAAACTTTTTACTGATTCAATCAACGGAAAA
TGCCCATATGTTGCTCATCGATGTCCATCTTATCAACATTTTGTGGATGGAAAATGCTTT
AAATGTAATTCAGGAAATTGTGCATTGATGGGTTATCATGCTCAAATGCCTTATTCCTAT
TCTCAATATAATTCTTCAGAAAATGATGTCATTCCATCAGAAAGTTACCCACCGATTGCT
CCAGTGCAGGGAAAATATTTTTTGACAACTGGCAAAGATCCCCATTATTGTCAACGTCAT
TATCGATTTATAATTGAACTCGCAAAACCAGTTATGGCTGAAAAATGGGTGCAAGGATTT
TTGAGTGCTGGCATCTTTACAGAACGTGGTAAAAATATGAGAAATTTAGATTTGACACCA
AAAGGTACTCAACGATTTGAACATGGAAAATCATATATGATTGTTATCACTAATCCCAAT
GATGTTGGCGATAAAATAAATAAAGTTGAACTAAATTGGAGTCATGAAATGAATGTTCTT
GAGCCTCGTAATTTATGCATCTTCTGGTGTAATGATCATTTATATGTAAAATCAGTGACT
GTTGATATGATGGAGATGCCAAGTAGAGAAAAGCGTGAATTGGAAAAATCTAATAAGCTT
TGCCCAAAGCAACAAGAATATGCTGATATCAAATCTCTTGGACGCATGCTCTTCTATGAT
AAGTGCAAGCAGCAGCAGTCATAG
>g943.t1 Gene=g943 Length=567
MLSCAASIVLIILNLVSLALSGPLDWAKAAVELPWARADRIPLDVNLPWLPFENETRCYG
EIGCLNITREWYHLIHRPFNVFPLPRNVINTRFILYTEENPTDGQLLVAEEKDTILNSNF
RPDRLTKFIIHGFIDTPLSTWVSEMKTELLKYSSQNQVIVVDWGSGSLPLYTQAVANTRL
VGLELAYLIKKLRDEHNLNPEDVHLIGHSLGSHLAAYAAERVPGIGRITGLDPAEPMFQS
MPEFVRLDPSDAKFVDVIHTDARSLFLLEIPGYGMSQACGHLDFYPNNGKEMPGCSLSQE
SSALIPLTLIKDGIEEASRVLLACNHVRAIKLFTDSINGKCPYVAHRCPSYQHFVDGKCF
KCNSGNCALMGYHAQMPYSYSQYNSSENDVIPSESYPPIAPVQGKYFLTTGKDPHYCQRH
YRFIIELAKPVMAEKWVQGFLSAGIFTERGKNMRNLDLTPKGTQRFEHGKSYMIVITNPN
DVGDKINKVELNWSHEMNVLEPRNLCIFWCNDHLYVKSVTVDMMEMPSREKRELEKSNKL
CPKQQEYADIKSLGRMLFYDKCKQQQS
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 27 | g943.t1 | CDD | cd00707 | Pancreat_lipase_like | 89 | 412 | 1.40472E-125 |
| 21 | g943.t1 | Gene3D | G3DSA:3.40.50.1820 | - | 55 | 392 | 2.1E-121 |
| 20 | g943.t1 | Gene3D | G3DSA:2.60.60.20 | Lipase/lipooxygenase domain (PLAT/LH2 domain) | 420 | 543 | 1.8E-7 |
| 2 | g943.t1 | PANTHER | PTHR11610:SF147 | PANCREATIC LIPASE-RELATED PROTEIN 2 | 55 | 500 | 2.8E-114 |
| 3 | g943.t1 | PANTHER | PTHR11610 | LIPASE | 55 | 500 | 2.8E-114 |
| 16 | g943.t1 | PRINTS | PR00823 | Pancreatic lipase signature | 56 | 73 | 7.8E-14 |
| 15 | g943.t1 | PRINTS | PR00823 | Pancreatic lipase signature | 73 | 84 | 7.8E-14 |
| 14 | g943.t1 | PRINTS | PR00823 | Pancreatic lipase signature | 93 | 105 | 7.8E-14 |
| 12 | g943.t1 | PRINTS | PR00823 | Pancreatic lipase signature | 111 | 125 | 7.8E-14 |
| 7 | g943.t1 | PRINTS | PR00821 | Triacylglycerol lipase family signature | 114 | 133 | 7.7E-32 |
| 9 | g943.t1 | PRINTS | PR00821 | Triacylglycerol lipase family signature | 135 | 149 | 7.7E-32 |
| 11 | g943.t1 | PRINTS | PR00823 | Pancreatic lipase signature | 158 | 177 | 7.8E-14 |
| 8 | g943.t1 | PRINTS | PR00821 | Triacylglycerol lipase family signature | 159 | 174 | 7.7E-32 |
| 6 | g943.t1 | PRINTS | PR00821 | Triacylglycerol lipase family signature | 179 | 198 | 7.7E-32 |
| 10 | g943.t1 | PRINTS | PR00821 | Triacylglycerol lipase family signature | 202 | 220 | 7.7E-32 |
| 13 | g943.t1 | PRINTS | PR00823 | Pancreatic lipase signature | 263 | 280 | 7.8E-14 |
| 5 | g943.t1 | PRINTS | PR00821 | Triacylglycerol lipase family signature | 324 | 339 | 7.7E-32 |
| 4 | g943.t1 | PRINTS | PR00821 | Triacylglycerol lipase family signature | 354 | 371 | 7.7E-32 |
| 1 | g943.t1 | Pfam | PF00151 | Lipase | 58 | 376 | 1.2E-99 |
| 23 | g943.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 21 | - |
| 24 | g943.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 1 | - |
| 25 | g943.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 2 | 13 | - |
| 26 | g943.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 14 | 21 | - |
| 22 | g943.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 22 | 567 | - |
| 17 | g943.t1 | SUPERFAMILY | SSF53474 | alpha/beta-Hydrolases | 58 | 379 | 2.89E-78 |
| 19 | g943.t1 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 21 | - |
| 18 | g943.t1 | SignalP_GRAM_POSITIVE | SignalP-TM | SignalP-TM | 1 | 29 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004806 | triglyceride lipase activity | MF |
| GO:0006629 | lipid metabolic process | BP |
KEGG
Orthology
- This transcript has been annotated with K14075 (pancreatic lipase-related protein 2)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
