General information for g9588.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Glutathione hydrolase 1 proenzyme.
Parent gene
- The parent gene g9588 is located on chr_1: 4147990..4149665 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g9588 | g9588.t1 | isoform | g9588.t1 | 4147990 | 4149665 |
| chr_1 | g9588 | g9588.t1 | exon | g9588.t1.exon1 | 4147990 | 4149473 |
| chr_1 | g9588 | g9588.t1 | cds | g9588.t1.CDS1 | 4147990 | 4149473 |
| chr_1 | g9588 | g9588.t1 | exon | g9588.t1.exon2 | 4149533 | 4149665 |
| chr_1 | g9588 | g9588.t1 | cds | g9588.t1.CDS2 | 4149533 | 4149665 |
| chr_1 | g9588 | g9588.t1 | TSS | g9588.t1 | NA | NA |
| chr_1 | g9588 | g9588.t1 | TTS | g9588.t1 | NA | NA |
Sequences
>g9588.t1 Gene=g9588 Length=1617
ATGAAACCAAAAGCAAAAGGTGCAATCGTATCCAATGGAGAGGAATGTGCAAAAATAGGC
GCCGATATACTGAAATTAGGTGGGAATGTTGTCGACGCAGGAATCAGTACACTAATTTGT
GACGGAGTAACAAATCCACAATCAGGAGGGCTGGGAGGTGGTATGCTTGCGACTTTATAT
TTAAAGAACAAAAAATTAATAACGTCCTTAGATGCTCGTGAAGTTGCACCAAAAAGTGCA
TCAGAAAATATGTATAATGAAGATTATACAAAATCTTTAAAGGGAGGGTTAGCAGTTGCA
GTTCCAGGAGAACTTTTAGGGATGAATGAAATGCACAAAAAATATGGTAATTTAGAATGG
GAAAAATTATTCAAGCCTGTAATTGAGCTCTGTCAAAAAGGACATACAATGACAGAAAAT
TTACACCTGATGCTTACTTTAAATATAGACATGATTACTAGGAATCCATCGTTTAATGGA
ATTTTTATAAACCAAAAAACAGGAAAATTATATGAAGTTGGTGAAAAAATTATTCGCAAA
GATTTAGCAAAAACTCTTAAGATAATTGCAGCAGAAAAATCTCAAGCAATGTATGGAGAA
AATGGGTCAATAATGAGGGAATTGGTTAAGGAAATCAACCAACACGGTGGAAATATTACC
GAGGAAGATTTTAAAAATTATAAAGTAAAATGGCGTAAACCCCTACAAACATCGTTGAAA
AGTGGAGAAACAATCTATACCGCGCCTCTGCCTGGATCAGGACAAACACTAATATACATT
TTAAACCTGCTCAAAAAGTTCAGTATAAAAGAGGACACTTTATCGAAACACATCATTATA
GAAACATATAAAAATGCATTTTCTAGAAGATCTTTACTTGGAGATCAAGAATTTTATATG
CCAGCAGGTAACACACAAAATTATATGATTTCGGAGGAATATGCTGAGGTAATGAGAAGA
CACATTGATGAGAAAACAACACATAGTATAAATTACTATGGCTACAAAATTTCAAATGTA
AAATCAAAAGGTACGATGCATGTAAGCATCTTGTCTGAAGATGGCGATGCCATATCAATA
ACATCCTCGATAAATGACCTTTTTGGAGCAAAAATTTTAAGTAATACTGGAATAGTCCTC
AATTCCCAAATGAACGATTTCTCAATCCCAGGAACTGCAAATATGTATGGACTACCACCA
TCAATTGCCAATATTATAAAACCAGGTAAAAGACCGTTGTCCTCGATGTCTCCCACAATA
ATTTTGAAAAAAAATAAGGAAGTTTCTATGGTTATTGGAGCCGCTGGTGGAAGTAAAATT
CCAACCGTTGTTGCGAAAATAATCTTAGACATGTATTTGAATGAAAATAAAGACTCTTTG
GAGAATGTTATTAAGAAAAAAAGATTCCATCATCAGTTGGTTCCCAATAAAATATATTTT
GAAAACGGGTTTGATAAACAAATCATAAAAGAATTGAACAATACTTTTAATCATGAATAC
GAAATTATTCAAGAAAAATTTAGATTTGGAGGCGTCTGTTCAATATTTGTTGATGAGGAT
AATAATATAGAAGCAAGTTACGACCCGCGACGAGGTGGTAGTCGACAATATCTTTAA
>g9588.t1 Gene=g9588 Length=538
MKPKAKGAIVSNGEECAKIGADILKLGGNVVDAGISTLICDGVTNPQSGGLGGGMLATLY
LKNKKLITSLDAREVAPKSASENMYNEDYTKSLKGGLAVAVPGELLGMNEMHKKYGNLEW
EKLFKPVIELCQKGHTMTENLHLMLTLNIDMITRNPSFNGIFINQKTGKLYEVGEKIIRK
DLAKTLKIIAAEKSQAMYGENGSIMRELVKEINQHGGNITEEDFKNYKVKWRKPLQTSLK
SGETIYTAPLPGSGQTLIYILNLLKKFSIKEDTLSKHIIIETYKNAFSRRSLLGDQEFYM
PAGNTQNYMISEEYAEVMRRHIDEKTTHSINYYGYKISNVKSKGTMHVSILSEDGDAISI
TSSINDLFGAKILSNTGIVLNSQMNDFSIPGTANMYGLPPSIANIIKPGKRPLSSMSPTI
ILKKNKEVSMVIGAAGGSKIPTVVAKIILDMYLNENKDSLENVIKKKRFHHQLVPNKIYF
ENGFDKQIIKELNNTFNHEYEIIQEKFRFGGVCSIFVDEDNNIEASYDPRRGGSRQYL
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 15 | g9588.t1 | Gene3D | G3DSA:1.10.246.130 | - | 234 | 337 | 0 |
| 14 | g9588.t1 | Gene3D | G3DSA:3.60.20.40 | - | 340 | 537 | 0 |
| 2 | g9588.t1 | PANTHER | PTHR11686 | GAMMA GLUTAMYL TRANSPEPTIDASE | 5 | 535 | 0 |
| 3 | g9588.t1 | PANTHER | PTHR11686:SF51 | GAMMA-GLUTAMYL TRANSPEPTIDASE, ISOFORM A | 5 | 535 | 0 |
| 5 | g9588.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 29 | 54 | 0 |
| 8 | g9588.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 98 | 116 | 0 |
| 4 | g9588.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 116 | 135 | 0 |
| 11 | g9588.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 218 | 234 | 0 |
| 10 | g9588.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 248 | 267 | 0 |
| 9 | g9588.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 345 | 363 | 0 |
| 6 | g9588.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 368 | 386 | 0 |
| 12 | g9588.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 408 | 423 | 0 |
| 7 | g9588.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 433 | 450 | 0 |
| 1 | g9588.t1 | Pfam | PF01019 | Gamma-glutamyltranspeptidase | 22 | 533 | 0 |
| 13 | g9588.t1 | SUPERFAMILY | SSF56235 | N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 6 | 534 | 0 |
| 16 | g9588.t1 | TIGRFAM | TIGR00066 | g_glut_trans: gamma-glutamyltransferase | 10 | 530 | 0 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0006751 | glutathione catabolic process | BP |
| GO:0036374 | glutathione hydrolase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K18592 (gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
