General information for g9598.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Atrial natriuretic peptide receptor 1.
Parent gene
- The parent gene g9598 is located on chr_1: 4224994..4230856 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g9598 | g9598.t1 | isoform | g9598.t1 | 4224994 | 4230856 |
| chr_1 | g9598 | g9598.t1 | exon | g9598.t1.exon1 | 4224994 | 4225539 |
| chr_1 | g9598 | g9598.t1 | cds | g9598.t1.CDS1 | 4224994 | 4225539 |
| chr_1 | g9598 | g9598.t1 | exon | g9598.t1.exon2 | 4227456 | 4227738 |
| chr_1 | g9598 | g9598.t1 | cds | g9598.t1.CDS2 | 4227456 | 4227738 |
| chr_1 | g9598 | g9598.t1 | exon | g9598.t1.exon3 | 4228164 | 4228420 |
| chr_1 | g9598 | g9598.t1 | cds | g9598.t1.CDS3 | 4228164 | 4228420 |
| chr_1 | g9598 | g9598.t1 | exon | g9598.t1.exon4 | 4228476 | 4229129 |
| chr_1 | g9598 | g9598.t1 | cds | g9598.t1.CDS4 | 4228476 | 4229129 |
| chr_1 | g9598 | g9598.t1 | exon | g9598.t1.exon5 | 4229198 | 4229261 |
| chr_1 | g9598 | g9598.t1 | cds | g9598.t1.CDS5 | 4229198 | 4229261 |
| chr_1 | g9598 | g9598.t1 | exon | g9598.t1.exon6 | 4229324 | 4229420 |
| chr_1 | g9598 | g9598.t1 | cds | g9598.t1.CDS6 | 4229324 | 4229420 |
| chr_1 | g9598 | g9598.t1 | exon | g9598.t1.exon7 | 4230049 | 4230199 |
| chr_1 | g9598 | g9598.t1 | cds | g9598.t1.CDS7 | 4230049 | 4230199 |
| chr_1 | g9598 | g9598.t1 | exon | g9598.t1.exon8 | 4230278 | 4230446 |
| chr_1 | g9598 | g9598.t1 | cds | g9598.t1.CDS8 | 4230278 | 4230446 |
| chr_1 | g9598 | g9598.t1 | exon | g9598.t1.exon9 | 4230675 | 4230856 |
| chr_1 | g9598 | g9598.t1 | cds | g9598.t1.CDS9 | 4230675 | 4230856 |
| chr_1 | g9598 | g9598.t1 | TSS | g9598.t1 | NA | NA |
| chr_1 | g9598 | g9598.t1 | TTS | g9598.t1 | NA | NA |
Sequences
>g9598.t1 Gene=g9598 Length=2403
ATGGCACGAAAGAAATTTATCGCAATTTTATTGCATTTGATAATTGTTACTGTTCGTGTA
ACCATATGTGATGATAAACCATTGATGTATAACAATAGCATTAATACATCAAGTGAAATA
GATGATCATTTGGTGATATATAATAATGAACAGCAAGAATGCATGAAAACATTTTGTCCA
ATAGAGAATTCATACAACTTAAGAAGAACAATACACATTGCATTATTGCTGCCATCAAAA
CCACAAACTGATGAAATTAATGCACAGACATTATCTGCTATTGTACCTGTGATTGATCAT
GCTATTGAAAATGTTAAGAATCAGAAATTACTACAAGGCTATGAACTCGTAATTCATCCA
CGCGATACAAAATGCTCGAGTACATATGGACCTTTAGCTGCTTATGATTTGCATAGTCGT
AATCATGCTGACGTCTTTTTGGGTCCAATTTGTGATTATGTACTTGCCCCTGTAGCAAGG
TATGCTAGCGTGTGGAAAAAACCTGTGATCTCAACTGGTGGTCTTGCTGCTGCATTTAAT
TTTAAGCCTCAATTTCCTACATTAATAAGAATGATGAGCTATAGTGAAATGACAAATGCC
GTTCTAGAAATTGTCTCACATTTCAATTGGAAAATTTTCGGGTTCTTTTTTCATACATAT
GGAGATCAAACTAAAGGATTTAGTCCTTGTCATCATATAGTTGCGCCAATATATAAACAA
AATAATACAAATACAAACAATCAAAATAATAATGTACACGAAGGGTTTGATAATGCCACA
TTCGATGAATTAAAGGAGAAGCTCAAACGATTGAAAGAGAAGTCGAGAATTATTATAATG
TGTGCAAATCCCAAAACAATTCGTGAAATAATGATTGCAGCAGAAGATTTGAATATGATT
GACAGTGGCGAATATGTATTTTTTAATATTGAGATATTTGGAAGTTTAAAAAAAGACTTA
AGACCTTGGTATGATGAAATGGACGAAAGTAATCGAAATGAAAAGGCCAGAAAAGCCTAT
CAAGCTTTACTCACCATAACAACACGAAAGCCTGAAGATGAAGAATATCAAAAGTTTTCC
GACGAGGTTAAAGCACTAGCTAAAGAAAAGTACAATTATACTTTTAATGAGAATGAATTA
ATTAGTCAATTTGTATCGGCATTTCATGATGCTGTTCTGCTATTTGCGAATGCTCTTAAT
GATAGCATTCGAATTAATGGAGAAGATTCGCTTTTGAAGCCACTTAATGGCACACAATTG
ACACGACTTATGTGGAATAGAAGTTTTCGTGGTATAACGGGAAATGTTTCAATTGATTCA
AATGGAGATCGAAGAAGTGACTATTCCTTACTTGATATGAATCCCAATAATAATCATTTT
GAAATTGTGGCCAATTACATTCACAATAGCAATAACAACTCAAGTGAGCCTGAATTTGTA
CAATTCAAAAATATACATTGGGCGGGAGGACGAACAGAAGCGCCCGCAGATCGTCCCGAA
TGTGGTTTTGATGGCTCTCTTTGCCCTGAGGATTCATCGACAATGTTCGCCATTCTTTCT
ATGGTTCTCGCTTTGATTGTCGTTATTATGGCTATTGTTTCATTTATTAGCTATCGGCAT
TACAAATTAGAGGCAGAAATCAGTTCGATGACTTGGCGTATAAATTGGAATGAAGTCATC
CCCATGCTAACAGCTAATCAACTTAGAGGCAGCATTCATTCGCGAGTGGGCTCACAATTG
TCTGTATATTCTGAAGAGTTGATGGGCGACAAACAAATTTTTGTCCCGATTGGATGTTAT
AAAGGAAATACTGTTGCAATCAAGAAAATAACAATGCCCATAAATTTATCACGATCATTA
ATGATGGAATTAAAGACTATGAAGGACATTCAACATGATAATCTCGTTCGTTTTTATGGC
GCTGTAATTGATAGCCTTCCATGTATTCTTACTGAATATTGTCCAAAAGGATCATTGCAA
GACATTCTAGAAAATCACGAAATCAATTTAGACTTGATGTTTAAATTGTCACTAATGCAT
GATCTTGTTAAAGGCATGCATTATCTTCATTCAACACCAATTCATTCACATGGACAATTG
AAATCATCCAATTGCGTTGTGGACTCTCGATTTGTACTGAAAATTACGGACTTTGGTCTA
CATGACTTAAGGAAAACAACAGACGACACAGAAAATAAAGATAGTCATGAATATTGGAAG
AAATTCTTATGGACAGCACCAGAATTGCTAAGAGAAAACGACTGTTCAAGTCGTGGAACG
CAAAAAGGCGATGTCTATAGTTTCGCAATAATCGTACAGGAAATTTGTTGTCGTCAGGGT
GTTTTTTATTTAGGAAATCAATATCATGAGAAAACGCCAAAAGGTCAGTATACAAAAATT
TAA
>g9598.t1 Gene=g9598 Length=800
MARKKFIAILLHLIIVTVRVTICDDKPLMYNNSINTSSEIDDHLVIYNNEQQECMKTFCP
IENSYNLRRTIHIALLLPSKPQTDEINAQTLSAIVPVIDHAIENVKNQKLLQGYELVIHP
RDTKCSSTYGPLAAYDLHSRNHADVFLGPICDYVLAPVARYASVWKKPVISTGGLAAAFN
FKPQFPTLIRMMSYSEMTNAVLEIVSHFNWKIFGFFFHTYGDQTKGFSPCHHIVAPIYKQ
NNTNTNNQNNNVHEGFDNATFDELKEKLKRLKEKSRIIIMCANPKTIREIMIAAEDLNMI
DSGEYVFFNIEIFGSLKKDLRPWYDEMDESNRNEKARKAYQALLTITTRKPEDEEYQKFS
DEVKALAKEKYNYTFNENELISQFVSAFHDAVLLFANALNDSIRINGEDSLLKPLNGTQL
TRLMWNRSFRGITGNVSIDSNGDRRSDYSLLDMNPNNNHFEIVANYIHNSNNNSSEPEFV
QFKNIHWAGGRTEAPADRPECGFDGSLCPEDSSTMFAILSMVLALIVVIMAIVSFISYRH
YKLEAEISSMTWRINWNEVIPMLTANQLRGSIHSRVGSQLSVYSEELMGDKQIFVPIGCY
KGNTVAIKKITMPINLSRSLMMELKTMKDIQHDNLVRFYGAVIDSLPCILTEYCPKGSLQ
DILENHEINLDLMFKLSLMHDLVKGMHYLHSTPIHSHGQLKSSNCVVDSRFVLKITDFGL
HDLRKTTDDTENKDSHEYWKKFLWTAPELLRENDCSSRGTQKGDVYSFAIIVQEICCRQG
VFYLGNQYHEKTPKGQYTKI
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 22 | g9598.t1 | CDD | cd06373 | PBP1_NPR-like | 72 | 471 | 2.98494E-178 |
| 14 | g9598.t1 | Gene3D | G3DSA:3.40.50.2300 | - | 93 | 445 | 1.5E-129 |
| 13 | g9598.t1 | Gene3D | G3DSA:3.40.50.2300 | - | 193 | 503 | 1.5E-129 |
| 12 | g9598.t1 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 597 | 799 | 2.6E-47 |
| 3 | g9598.t1 | PANTHER | PTHR11920 | GUANYLYL CYCLASE | 70 | 787 | 2.5E-175 |
| 4 | g9598.t1 | PANTHER | PTHR11920:SF300 | ATRIAL NATRIURETIC PEPTIDE RECEPTOR 1 | 70 | 787 | 2.5E-175 |
| 8 | g9598.t1 | PRINTS | PR00255 | Natriuretic peptide receptor signature | 147 | 165 | 4.4E-23 |
| 6 | g9598.t1 | PRINTS | PR00255 | Natriuretic peptide receptor signature | 276 | 294 | 4.4E-23 |
| 7 | g9598.t1 | PRINTS | PR00255 | Natriuretic peptide receptor signature | 431 | 448 | 4.4E-23 |
| 5 | g9598.t1 | PRINTS | PR00255 | Natriuretic peptide receptor signature | 518 | 540 | 4.4E-23 |
| 1 | g9598.t1 | Pfam | PF01094 | Receptor family ligand binding region | 97 | 457 | 2.8E-63 |
| 2 | g9598.t1 | Pfam | PF07714 | Protein tyrosine and serine/threonine kinase | 603 | 779 | 7.2E-35 |
| 17 | g9598.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 23 | - |
| 18 | g9598.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 6 | - |
| 19 | g9598.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 7 | 18 | - |
| 21 | g9598.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 19 | 23 | - |
| 16 | g9598.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 24 | 514 | - |
| 20 | g9598.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 515 | 538 | - |
| 15 | g9598.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 539 | 800 | - |
| 24 | g9598.t1 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 568 | 800 | 23.326 |
| 9 | g9598.t1 | SUPERFAMILY | SSF53822 | Periplasmic binding protein-like I | 70 | 503 | 2.38E-90 |
| 10 | g9598.t1 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 598 | 783 | 2.99E-43 |
| 11 | g9598.t1 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 23 | - |
| 23 | g9598.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 516 | 538 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005524 | ATP binding | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0016021 | integral component of membrane | CC |
| GO:0006468 | protein phosphorylation | BP |
KEGG
Orthology
- This transcript has been annotated with K12323 (atrial natriuretic peptide receptor A)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
