General information for g9805.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Kynureninase.
Parent gene
- The parent gene g9805 is located on chr_1: 5314331..5315566 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g9805 | g9805.t1 | TTS | g9805.t1 | 5314068 | 5314068 |
| chr_1 | g9805 | g9805.t1 | isoform | g9805.t1 | 5314331 | 5315566 |
| chr_1 | g9805 | g9805.t1 | exon | g9805.t1.exon1 | 5314331 | 5315566 |
| chr_1 | g9805 | g9805.t1 | cds | g9805.t1.CDS1 | 5314331 | 5315566 |
| chr_1 | g9805 | g9805.t1 | TSS | g9805.t1 | 5315755 | 5315755 |
Sequences
>g9805.t1 Gene=g9805 Length=1236
ATGACGCGTGAACAATGTGAAATAGCTGATGAAAATGATGAACTTAAAATTTTTCGCAAT
AAATTTAAAATTCCTCAAGATACAATTTACCTGATTGGCAATTCCCTTGGTCTTTGTCCA
ATTGAATCACAGAAAATTGCAAATCGTGTCATCAAACAAGAATGGGGTCAAAATCATATT
GATTCATGGAATACTGCTGGATGGTATCACTTGCCAGTAAAAGTTGGTAATAAAATTGGA
AAAATTATTGGTGCAGAACAAAATGAAACAATTATTTCCGATTCAACATCAATAAATATT
TTCAAATGCCTTGGAACTTCAATTGCAATTCAAAAAATCAAAAATCCTGATCGTCGAATC
ATTTTACTTGAACGTGAAAATTTCCCGACTGACCTCTACATCGCACAAGGTCTTGTTAAT
CTTCTCTCAACTGATGAATATAAAATTCGTTATTTTGATGACGATAATCGACTCGAAGAT
GTTTTAGGTGATGACGTTGTGTGTATATTATTGTCACATGTAAATTATCGAACTGGTCAA
TTATACAATATGAAACAAATTACAAAACTGGCCCATAAAGTTGATGCACATATTATTTGG
GACTTGTGTCATTCTGTTGGTTCTGTTCCTATCAATTTAACCAAAGTTGATGCTGATTTT
GCAGTTGGTTGCACTTATAAATATCTGAATAGTGGACCAGGTGCTCCTGCATTCATTTAT
GTTAATAAGAAACATCAAAATGTCGCTTGGCAACCATTGACTGGATGGTTTGGTCATCAA
GCTCCTTTTAAGATGTCAAAACTTTATGAACCTGCACCAAATATCACAAATTACCTTGTT
GGAACTCCACAAGTGTTACAAATTTCAATTATTGATCATAGTGTTGGAATCACACTTGAT
GCCGATATGCAAGCGATTAGAAAGAAATCTTTAGCCCTTGGTGATCTTTTTATTAAATTA
ATGGATGAAAAATGTCCATCACTTAAACTTGTTACACCATTTGAATATGAAAAAAGAGGA
AGCCATTTGAGTTATCAACATGAAAATGCTTATGCTATCAGCAATTTGATGAGAAAACGA
GGAGTTTATGGTGACTTTAGATTTCCTGATATTCTTAGATTTGCAATGACTCCATTATAT
ACAAGATTTGTCGACATTTGGGATGTAATTGGAATCATTTCGGAAGTTATTAATGATGCT
GAATATGAAGGATTTGATGGAAATTGCGTTACTTGA
>g9805.t1 Gene=g9805 Length=411
MTREQCEIADENDELKIFRNKFKIPQDTIYLIGNSLGLCPIESQKIANRVIKQEWGQNHI
DSWNTAGWYHLPVKVGNKIGKIIGAEQNETIISDSTSINIFKCLGTSIAIQKIKNPDRRI
ILLERENFPTDLYIAQGLVNLLSTDEYKIRYFDDDNRLEDVLGDDVVCILLSHVNYRTGQ
LYNMKQITKLAHKVDAHIIWDLCHSVGSVPINLTKVDADFAVGCTYKYLNSGPGAPAFIY
VNKKHQNVAWQPLTGWFGHQAPFKMSKLYEPAPNITNYLVGTPQVLQISIIDHSVGITLD
ADMQAIRKKSLALGDLFIKLMDEKCPSLKLVTPFEYEKRGSHLSYQHENAYAISNLMRKR
GVYGDFRFPDILRFAMTPLYTRFVDIWDVIGIISEVINDAEYEGFDGNCVT
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 8 | g9805.t1 | Coils | Coil | Coil | 1 | 21 | - |
| 6 | g9805.t1 | Gene3D | G3DSA:3.90.1150.10 | Aspartate Aminotransferase | 10 | 397 | 3.1E-142 |
| 7 | g9805.t1 | Gene3D | G3DSA:3.40.640.10 | - | 40 | 303 | 3.1E-142 |
| 4 | g9805.t1 | Hamap | MF_01970 | Kynureninase [kynU]. | 2 | 397 | 33.039879 |
| 2 | g9805.t1 | PANTHER | PTHR14084 | KYNURENINASE | 3 | 402 | 1.8E-94 |
| 3 | g9805.t1 | PANTHER | PTHR14084:SF0 | KYNURENINASE | 3 | 402 | 1.8E-94 |
| 9 | g9805.t1 | PIRSF | PIRSF038800 | KYNU | 1 | 405 | 4.1E-135 |
| 1 | g9805.t1 | Pfam | PF00266 | Aminotransferase class-V | 155 | 355 | 1.6E-13 |
| 5 | g9805.t1 | SUPERFAMILY | SSF53383 | PLP-dependent transferases | 2 | 400 | 1.75E-69 |
| 10 | g9805.t1 | TIGRFAM | TIGR01814 | kynureninase: kynureninase | 7 | 397 | 2.5E-93 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0030429 | kynureninase activity | MF |
| GO:0006569 | tryptophan catabolic process | BP |
| GO:0003824 | catalytic activity | MF |
| GO:0030170 | pyridoxal phosphate binding | MF |
| GO:0005737 | cytoplasm | CC |
| GO:0009435 | NAD biosynthetic process | BP |
KEGG
Orthology
- This transcript has been annotated with K01556 (kynureninase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed