General information for g986.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Angiotensin-converting enzyme .
Parent gene
- The parent gene g986 is located on chr_3: 7264712..7265470 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g986 | g986.t1 | TTS | g986.t1 | 7259512 | 7259512 |
| chr_3 | g986 | g986.t1 | isoform | g986.t1 | 7259639 | 7265470 |
| chr_3 | g986 | g986.t1 | exon | g986.t1.exon1 | 7259639 | 7260412 |
| chr_3 | g986 | g986.t1 | cds | g986.t1.CDS1 | 7259639 | 7260412 |
| chr_3 | g986 | g986.t1 | exon | g986.t1.exon2 | 7260478 | 7260556 |
| chr_3 | g986 | g986.t1 | cds | g986.t1.CDS2 | 7260478 | 7260556 |
| chr_3 | g986 | g986.t1 | exon | g986.t1.exon3 | 7260612 | 7261044 |
| chr_3 | g986 | g986.t1 | cds | g986.t1.CDS3 | 7260612 | 7261044 |
| chr_3 | g986 | g986.t1 | exon | g986.t1.exon4 | 7261106 | 7261200 |
| chr_3 | g986 | g986.t1 | cds | g986.t1.CDS4 | 7261106 | 7261200 |
| chr_3 | g986 | g986.t1 | exon | g986.t1.exon5 | 7261257 | 7261414 |
| chr_3 | g986 | g986.t1 | cds | g986.t1.CDS5 | 7261257 | 7261414 |
| chr_3 | g986 | g986.t1 | exon | g986.t1.exon6 | 7261468 | 7262357 |
| chr_3 | g986 | g986.t1 | cds | g986.t1.CDS6 | 7261468 | 7262357 |
| chr_3 | g986 | g986.t1 | exon | g986.t1.exon7 | 7262416 | 7262501 |
| chr_3 | g986 | g986.t1 | cds | g986.t1.CDS7 | 7262416 | 7262501 |
| chr_3 | g986 | g986.t1 | exon | g986.t1.exon8 | 7262563 | 7262664 |
| chr_3 | g986 | g986.t1 | cds | g986.t1.CDS8 | 7262563 | 7262664 |
| chr_3 | g986 | g986.t1 | exon | g986.t1.exon9 | 7262748 | 7262972 |
| chr_3 | g986 | g986.t1 | cds | g986.t1.CDS9 | 7262748 | 7262972 |
| chr_3 | g986 | g986.t1 | exon | g986.t1.exon10 | 7263029 | 7263221 |
| chr_3 | g986 | g986.t1 | cds | g986.t1.CDS10 | 7263029 | 7263221 |
| chr_3 | g986 | g986.t1 | exon | g986.t1.exon11 | 7263273 | 7263369 |
| chr_3 | g986 | g986.t1 | cds | g986.t1.CDS11 | 7263273 | 7263369 |
| chr_3 | g986 | g986.t1 | exon | g986.t1.exon12 | 7263429 | 7263749 |
| chr_3 | g986 | g986.t1 | cds | g986.t1.CDS12 | 7263429 | 7263749 |
| chr_3 | g986 | g986.t1 | exon | g986.t1.exon13 | 7264712 | 7264903 |
| chr_3 | g986 | g986.t1 | cds | g986.t1.CDS13 | 7264712 | 7264903 |
| chr_3 | g986 | g986.t1 | exon | g986.t1.exon14 | 7265465 | 7265470 |
| chr_3 | g986 | g986.t1 | cds | g986.t1.CDS14 | 7265465 | 7265470 |
| chr_3 | g986 | g986.t1 | TSS | g986.t1 | 7265656 | 7265656 |
Sequences
>g986.t1 Gene=g986 Length=3651
ATGAAGATAAAAATGTTGATGTTTTTGCAAATAATTGCGGTTGCATTAGTCAGTGTTAAT
GCACAATTAACAGAAGAACAAATGTTACAGCATTTAGAAGAATATGACAATAAAACAAAA
CTACTATGCAATGCACAAGCTAAAGCCAATTGGGCAGTTCAAACTGATGTTGGAAATCTA
ACTAAAGAAGCGGCTCAGGCTGAAGCTATTTTGGCTTATTCATCTTATAGACAAGAGCAA
TATGAAACAATTTTCAAAAATGCACCATCTTATTCAAATGAAGACATCACAAGAAAACTT
AAATTGCTTAAAGAAGTTGGAACTGCAGCTTTATCAGCAGATGATTTAAGAAATTTAACA
GCAACAAGAACAAGAATGTCGAAAATTTACAATTCAGCTAAAATTTGTCCATTCGATAAC
CAAAATTGTAATAAAACTACTCAAGGAATGTTTTTAGATCCAAATATTGAATTAGCTCTT
GCAAAATCAACAAATTATGATGAATTGCAGTATCTTTGGGAAAAATGGCGTGATGAATCA
GGAAAATTGATGAGAGATGACTATAAAACTTATATTGATTTATATAATAAAGCTGCACAA
CTTAATGGATATTCAGATGCTGGTGCAATGTGGAGAGGACGATATGAAGAAGAACGATTG
GTTGAAATTGTCGATGAATTATGGGCTGAAGTTGAGCCGCTCTATAACGAACTTCATACT
TACGTTCGATATAAATTGCTTGAAATTTATGGTGATAAAATGGACAAATATGATCCATTG
ATTCCAGCTCACGTTTTTGGTAACATGTGGGCACAAAATTGGGTTCATTTATATGAAAGA
ATTAAACCATTCAAAAATGCTTCATCAGTTGATGTCACAAAAAATATGGAAGAAATGAAT
ATGACTGTCTATAAAATGTTTGAACTTAGTGATGAATTTTATATGAGTATGGGATTACCA
ACAAGTAACATGAGTTACACAGGAGAATCAGTGATTGAAAGAATTCCAGGAGTTAATATG
GCTTGTCATGCTAGTGCTTGGGATTTCTGTGATGGTGAAGATTTCCGTATAAAAATGTGC
ACAAAAATTAATCAAGAAGATTTTATAGTTGTTCATCATGAGATGGGTCATATTATGTAC
TATTTATTGTACAAAGATTTGCCATTGATTTATAGAGGGGGTGCAAATCCAGGTTTCCAT
GAAGCTATTGGCGATACAATTGCTCTTTCGGTTTCAACACCAAAACATTTGGAGAAAGTT
GGTCTTTTAAGTGGTTACCAAAACAGTGAGGCTGACAATATCAACGCACTTTTCCATATG
GCACTCGAACGTGTTGCTTTCCTTCCATTTGGTTTGTTGATTGATAAATGGCGTTGGGAC
TTATTTAGTGGTGCAACACCTGAATCTGAATGGAATAAACATTGGTGGGAACTACGAGAA
AAATACCAAAAAATTCGAGCACCATCACCTCGTGGTGAAGAATTTTTCGATCCAGGCGCA
AAATATCACATTCCAGCTGATTCACAATACATTGCATATTTTGTTGCTCATATTTTGGAA
TTTAGTTTCTATAAAAGCCTTTGTATTGAAGCAGGTCAATATAATGTTTCAAATCCATCA
GAACATCCACTTCATACATGTGATTTCTTCGAAAGTAAAGCAGCTGGTGAAAAACTAAAT
GCTGGTTTAAAACTTGGCATGAGCAAACATTGGAGTGAAGCACTTAATGAACTTACAGGA
TCACCAAATATTTCAGCATCAGCACTTGTTGAATATTTTGCACCACTCAAAGATTATTTG
GCTGAACAAAATAAAATTATGAAAAATGCAAGAATGGCAGAAATTCTTCAAGAATATGAA
GTAGAAGGATCTGCAATGTGCAATAAATTGGTTAAAGCTGAATGGGCAGTTGCTACTGAT
TCCAATAATGATGCTTTAAAGACAGAATATGAAAGAATTGTACTAGAAAACAATGCCTTT
ACCAAAGATTATTATGAAAAAGCATTTAAAGGAGAAAAACCAGAAGATTATAATGATGAA
TTAATTCAAAGACAATTAAAATATTTGACAAAACTTGGTCGTGATGCTTTGGAAATTGCA
GATTTAAGCAATTTGACAAACACACAAACTCGCATGGAAAAAATTTATAATACAGCAAAA
ATTTGTCCATTTAATAAACAAAATTGTAATTTAGCTACAGAAGGTCTTACACTTGATCCT
GATCTTTCTGATCTGTTAGCTACTTCTACAAACTATGATGAATTAGAATGGGCTTGGACA
CAATGGCGTGAAAAGAGTGGAAAACTTATGAGAGATGACTACAAAATTTATATTGAACTT
CTTAATGAAGCTGCTAAATTAAATGGCAAAAACGACTATGGTGAAATTTGGCGTGAATCA
TATGAAGATGATAAATTGTATGAAAATGTTGACAAAATGTGGGATAAAGTTGAGCCACTT
TACAATGAACTTCACACTTATGTTCGTAGAAAGTTGAAGAAAATTTATGGTGATAAAATG
GACGACAAAGATGAAATGATCCCAGCACATCTTTTAGGCAACATGTGGGCACAGAGTTGG
ATAAATTTGTATGAACGTATAAAACCATACTCAGGTGGAAGTTCAATTGATATCACTGAA
AATTTGAAAAATCAAAATGTGACAGTTTTGAAAATGTTTGAAATGAGCAATGATTTCTTC
ATGGGTTTGGGATTGCCAAATAATAGCATGTCTTATGATGAATCACTTGGTGCTGTTATT
AAGAAACCTGATAATAAAGTTATTACTTGTCATGCTAGTGCTTGGGATTTCTGTGATGGC
AAAGATTTTCGTATTAAAATGTGTACAAGCATCAATCAAGAAGATTTCATCACAGTTCAT
CACGAAATGGGTCACATTAATTATTTCATTCTCTACAAAGATCAACCATTAGTCCTTCGT
ACTGGTGCTAATCCAGGTTTCCATGAAGCTGTTGGTGATCTTATTGCATTATCAGTGTCA
ACACCAAAACATTTAGAAAAAGTTGGACTTTTAAGTGACTATAAAGACACTGAAGAAGAC
AACATTAATGCACTCTTTAAAATGGCACTTGAACGTGTTGCTTTCCTTCCATTTGGTTTG
TTGATTGATAAATGGCGTTGGGACTTATTCAGTGGTGCAACACCTGAATCTGAATGGAAT
AAACATTGGTGGGAACTACGAGAAAAATACCAAAAAGTTCGAGCACCATCACCTCGTAAT
GAAACTTTCTTCGATCCAGGCGCAAAATATCACATTCCAGCAGATTCACAATACATTGCT
TACTTTATTGCACACATTTTGGAATTCCAACTTCATCGTGGCATGTGTCTTGCTGCTGGT
CAATATGTTGAAGGTGATAAAACAAAACCATTGCATAAATGTGACATTGATAGTTCAAAG
GCTGCAGGAAAATTAATTGAAAACGGTTTGAAACTTGGATTAAGCAAACACTGGAGTGAA
GCATTGAAAGCAATGACTGGTGAGACTGAAATTTCTGGTGAAGCATTGTTTGATTATTTC
AAGCCACTTTATGATTTCCTTAAAGAAGAAAATGAGAAAGATAGTTCAATGATTGTCCAC
GTTAATGTTATTTTACTTCTTGGAGTTTTACTTGTTAAATATTTTTTGTAA
>g986.t1 Gene=g986 Length=1216
MKIKMLMFLQIIAVALVSVNAQLTEEQMLQHLEEYDNKTKLLCNAQAKANWAVQTDVGNL
TKEAAQAEAILAYSSYRQEQYETIFKNAPSYSNEDITRKLKLLKEVGTAALSADDLRNLT
ATRTRMSKIYNSAKICPFDNQNCNKTTQGMFLDPNIELALAKSTNYDELQYLWEKWRDES
GKLMRDDYKTYIDLYNKAAQLNGYSDAGAMWRGRYEEERLVEIVDELWAEVEPLYNELHT
YVRYKLLEIYGDKMDKYDPLIPAHVFGNMWAQNWVHLYERIKPFKNASSVDVTKNMEEMN
MTVYKMFELSDEFYMSMGLPTSNMSYTGESVIERIPGVNMACHASAWDFCDGEDFRIKMC
TKINQEDFIVVHHEMGHIMYYLLYKDLPLIYRGGANPGFHEAIGDTIALSVSTPKHLEKV
GLLSGYQNSEADNINALFHMALERVAFLPFGLLIDKWRWDLFSGATPESEWNKHWWELRE
KYQKIRAPSPRGEEFFDPGAKYHIPADSQYIAYFVAHILEFSFYKSLCIEAGQYNVSNPS
EHPLHTCDFFESKAAGEKLNAGLKLGMSKHWSEALNELTGSPNISASALVEYFAPLKDYL
AEQNKIMKNARMAEILQEYEVEGSAMCNKLVKAEWAVATDSNNDALKTEYERIVLENNAF
TKDYYEKAFKGEKPEDYNDELIQRQLKYLTKLGRDALEIADLSNLTNTQTRMEKIYNTAK
ICPFNKQNCNLATEGLTLDPDLSDLLATSTNYDELEWAWTQWREKSGKLMRDDYKIYIEL
LNEAAKLNGKNDYGEIWRESYEDDKLYENVDKMWDKVEPLYNELHTYVRRKLKKIYGDKM
DDKDEMIPAHLLGNMWAQSWINLYERIKPYSGGSSIDITENLKNQNVTVLKMFEMSNDFF
MGLGLPNNSMSYDESLGAVIKKPDNKVITCHASAWDFCDGKDFRIKMCTSINQEDFITVH
HEMGHINYFILYKDQPLVLRTGANPGFHEAVGDLIALSVSTPKHLEKVGLLSDYKDTEED
NINALFKMALERVAFLPFGLLIDKWRWDLFSGATPESEWNKHWWELREKYQKVRAPSPRN
ETFFDPGAKYHIPADSQYIAYFIAHILEFQLHRGMCLAAGQYVEGDKTKPLHKCDIDSSK
AAGKLIENGLKLGLSKHWSEALKAMTGETEISGEALFDYFKPLYDFLKEENEKDSSMIVH
VNVILLLGVLLVKYFL
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 26 | g986.t1 | CDD | cd06461 | M2_ACE | 32 | 604 | 0.0 |
| 25 | g986.t1 | CDD | cd06461 | M2_ACE | 616 | 1191 | 0.0 |
| 17 | g986.t1 | Coils | Coil | Coil | 1216 | 1216 | - |
| 4 | g986.t1 | PANTHER | PTHR10514 | ANGIOTENSIN-CONVERTING ENZYME | 13 | 605 | 0.0 |
| 3 | g986.t1 | PANTHER | PTHR10514 | ANGIOTENSIN-CONVERTING ENZYME | 606 | 1198 | 0.0 |
| 9 | g986.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 810 | 837 | 6.0E-82 |
| 7 | g986.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 845 | 866 | 6.0E-82 |
| 11 | g986.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 924 | 949 | 6.0E-82 |
| 5 | g986.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 956 | 972 | 6.0E-82 |
| 12 | g986.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 984 | 1004 | 6.0E-82 |
| 8 | g986.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 1025 | 1050 | 6.0E-82 |
| 10 | g986.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 1060 | 1087 | 6.0E-82 |
| 6 | g986.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 1088 | 1116 | 6.0E-82 |
| 2 | g986.t1 | Pfam | PF01401 | Angiotensin-converting enzyme | 24 | 606 | 2.4E-197 |
| 1 | g986.t1 | Pfam | PF01401 | Angiotensin-converting enzyme | 609 | 1196 | 1.6E-201 |
| 20 | g986.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 21 | - |
| 21 | g986.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 5 | - |
| 22 | g986.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 6 | 17 | - |
| 24 | g986.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 18 | 21 | - |
| 19 | g986.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 22 | 1196 | - |
| 23 | g986.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 1197 | 1215 | - |
| 18 | g986.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 1216 | 1216 | - |
| 14 | g986.t1 | SUPERFAMILY | SSF55486 | Metalloproteases (zincins), catalytic domain | 25 | 605 | 2.78E-191 |
| 13 | g986.t1 | SUPERFAMILY | SSF55486 | Metalloproteases (zincins), catalytic domain | 610 | 1194 | 3.99E-196 |
| 16 | g986.t1 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 21 | - |
| 27 | g986.t1 | SignalP_GRAM_NEGATIVE | SignalP-noTM | SignalP-noTM | 1 | 21 | - |
| 15 | g986.t1 | SignalP_GRAM_POSITIVE | SignalP-TM | SignalP-TM | 1 | 23 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016020 | membrane | CC |
| GO:0008241 | peptidyl-dipeptidase activity | MF |
| GO:0008237 | metallopeptidase activity | MF |
| GO:0006508 | proteolysis | BP |
KEGG
Orthology
- This transcript has been annotated with K01283 (peptidyl-dipeptidase A)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed