General information for g986.t6
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Putative Angiotensin-converting enzyme-like protein Ace3.
Parent gene
- The parent gene g986 is located on chr_3: 7264712..7265470 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g986 | g986.t6 | isoform | g986.t6 | 7263028 | 7265470 |
| chr_3 | g986 | g986.t6 | exon | g986.t6.exon1 | 7263028 | 7263221 |
| chr_3 | g986 | g986.t6 | cds | g986.t6.CDS1 | 7263028 | 7263221 |
| chr_3 | g986 | g986.t6 | exon | g986.t6.exon2 | 7263273 | 7263369 |
| chr_3 | g986 | g986.t6 | cds | g986.t6.CDS2 | 7263273 | 7263369 |
| chr_3 | g986 | g986.t6 | exon | g986.t6.exon3 | 7263429 | 7263749 |
| chr_3 | g986 | g986.t6 | cds | g986.t6.CDS3 | 7263429 | 7263749 |
| chr_3 | g986 | g986.t6 | exon | g986.t6.exon4 | 7264712 | 7264903 |
| chr_3 | g986 | g986.t6 | cds | g986.t6.CDS4 | 7264712 | 7264903 |
| chr_3 | g986 | g986.t6 | exon | g986.t6.exon5 | 7265465 | 7265470 |
| chr_3 | g986 | g986.t6 | cds | g986.t6.CDS5 | 7265465 | 7265470 |
| chr_3 | g986 | g986.t6 | TSS | g986.t6 | 7265656 | 7265656 |
| chr_3 | g986 | g986.t6 | TTS | g986.t6 | NA | NA |
Sequences
>g986.t6 Gene=g986 Length=810
ATGAAGATAAAAATGTTGATGTTTTTGCAAATAATTGCGGTTGCATTAGTCAGTGTTAAT
GCACAATTAACAGAAGAACAAATGTTACAGCATTTAGAAGAATATGACAATAAAACAAAA
CTACTATGCAATGCACAAGCTAAAGCCAATTGGGCAGTTCAAACTGATGTTGGAAATCTA
ACTAAAGAAGCGGCTCAGGCTGAAGCTATTTTGGCTTATTCATCTTATAGACAAGAGCAA
TATGAAACAATTTTCAAAAATGCACCATCTTATTCAAATGAAGACATCACAAGAAAACTT
AAATTGCTTAAAGAAGTTGGAACTGCAGCTTTATCAGCAGATGATTTAAGAAATTTAACA
GCAACAAGAACAAGAATGTCGAAAATTTACAATTCAGCTAAAATTTGTCCATTCGATAAC
CAAAATTGTAATAAAACTACTCAAGGAATGTTTTTAGATCCAAATATTGAATTAGCTCTT
GCAAAATCAACAAATTATGATGAATTGCAGTATCTTTGGGAAAAATGGCGTGATGAATCA
GGAAAATTGATGAGAGATGACTATAAAACTTATATTGATTTATATAATAAAGCTGCACAA
CTTAATGGATATTCAGATGCTGGTGCAATGTGGAGAGGACGATATGAAGAAGAACGATTG
GTTGAAATTGTCGATGAATTATGGGCTGAAGTTGAGCCGCTCTATAACGAACTTCATACT
TACGTTCGATATAAATTGCTTGAAATTTATGGTGATAAAATGGACAAATATGATCCATTG
ATTCCAGCTCACGTTTTTGGTAACATGTGG
>g986.t6 Gene=g986 Length=270
MKIKMLMFLQIIAVALVSVNAQLTEEQMLQHLEEYDNKTKLLCNAQAKANWAVQTDVGNL
TKEAAQAEAILAYSSYRQEQYETIFKNAPSYSNEDITRKLKLLKEVGTAALSADDLRNLT
ATRTRMSKIYNSAKICPFDNQNCNKTTQGMFLDPNIELALAKSTNYDELQYLWEKWRDES
GKLMRDDYKTYIDLYNKAAQLNGYSDAGAMWRGRYEEERLVEIVDELWAEVEPLYNELHT
YVRYKLLEIYGDKMDKYDPLIPAHVFGNMW
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 2 | g986.t6 | PANTHER | PTHR10514 | ANGIOTENSIN-CONVERTING ENZYME | 13 | 270 | 9.2E-70 |
| 4 | g986.t6 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 224 | 251 | 2.7E-9 |
| 3 | g986.t6 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 259 | 270 | 2.7E-9 |
| 1 | g986.t6 | Pfam | PF01401 | Angiotensin-converting enzyme | 24 | 270 | 1.0E-59 |
| 9 | g986.t6 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 21 | - |
| 10 | g986.t6 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 5 | - |
| 11 | g986.t6 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 6 | 17 | - |
| 12 | g986.t6 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 18 | 21 | - |
| 8 | g986.t6 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 22 | 270 | - |
| 5 | g986.t6 | SUPERFAMILY | SSF55486 | Metalloproteases (zincins), catalytic domain | 25 | 270 | 1.59E-58 |
| 7 | g986.t6 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 21 | - |
| 13 | g986.t6 | SignalP_GRAM_NEGATIVE | SignalP-noTM | SignalP-noTM | 1 | 21 | - |
| 6 | g986.t6 | SignalP_GRAM_POSITIVE | SignalP-TM | SignalP-TM | 1 | 23 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016020 | membrane | CC |
| GO:0008241 | peptidyl-dipeptidase activity | MF |
| GO:0008237 | metallopeptidase activity | MF |
| GO:0006508 | proteolysis | BP |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed