General information for g12728.t17
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Aldo-keto reductase family 1 member B10.
Parent gene
- The parent gene g12728 is located on chr_1: 25507881..25508906 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12728 | g12728.t17 | TTS | g12728.t17 | 25507381 | 25507381 |
| chr_1 | g12728 | g12728.t17 | isoform | g12728.t17 | 25507464 | 25508906 |
| chr_1 | g12728 | g12728.t17 | exon | g12728.t17.exon1 | 25507464 | 25507765 |
| chr_1 | g12728 | g12728.t17 | cds | g12728.t17.CDS1 | 25507464 | 25507765 |
| chr_1 | g12728 | g12728.t17 | exon | g12728.t17.exon2 | 25507838 | 25508414 |
| chr_1 | g12728 | g12728.t17 | cds | g12728.t17.CDS2 | 25507838 | 25508414 |
| chr_1 | g12728 | g12728.t17 | exon | g12728.t17.exon3 | 25508840 | 25508906 |
| chr_1 | g12728 | g12728.t17 | cds | g12728.t17.CDS3 | 25508840 | 25508878 |
| chr_1 | g12728 | g12728.t17 | TSS | g12728.t17 | 25508972 | 25508972 |
Sequences
>g12728.t17 Gene=g12728 Length=946
ATGGCAGCACCTACTGTTACTCTCAATAATGGCAAACAATTTCCAATCGTTGGCCTTGGT
AATGAAATCACCACCTGGTGTTGTTGCTCAAGCTGTAAAAGACGCAATTGATGCTGGCTA
TCGTCATTTTGACGGTGCTCATGTATATGAAAATGAGCATGAAGTTGGTGAAGGAATTAA
TGCTAAAATCGCTGAAGGTGTTATCAAACGTGAAGACGTTTTTGTAACATCAAAATTATG
GTGCACTTTCCATGACCCAAAGGATGTTCGTGGTGCACTCGAGCATACATTGAAACAATT
AAATTTAGATTATCTTGACTTGTACCTCATGCATTGGCCTATTTGTTATCAAAAATCAAC
TGAATTGTTCCCAAAGAATGAAGCTGGTGAAATTTTGCACGCTAATTTTGATATTCTTGA
CACTTATCGTGCAATGGAGGAACTTGTTGATGCTGGATTGACTAAAAGTATTGGAATTTC
AAACTTCAATATCAAACAAGTTGAGTACATTACTAAAAATGCTCGCATCCAACCAGTCAC
CAATCAAGTTGAATGCAATCCATATTTACTTAATAAAGAATTAAGTGATTTCTGCAAAAG
TAAAAACATTGTCATCACCGCTTATTCACCTCTTGGTTCACCAGGTCGTCCATGGGCAAC
ACCAGATGACCGAGTATTATTAAAAGAACCAAAACTTTTAGAGATCGCTCAGAAGCACAA
TAAAACACCAGCACAAATTTTAATCCGTTACCAAATTCAACGCGGTCACGTTGTCATACC
GAAATCAGTTACGAAGGATCGCATAATCAGTAATTTTGATGTTTTCAACTTCACATTGAG
CGATTCTGAAATAAAAGATTTGGAAAACTTCAACTATACTGAGCGCATTTGTAGCATGTC
TCAAGATAAACATCATCCAGCTTATCCTTTCAATGACGACGCCTAA
>g12728.t17 Gene=g12728 Length=305
MANNFQSLALVMKSPPGVVAQAVKDAIDAGYRHFDGAHVYENEHEVGEGINAKIAEGVIK
REDVFVTSKLWCTFHDPKDVRGALEHTLKQLNLDYLDLYLMHWPICYQKSTELFPKNEAG
EILHANFDILDTYRAMEELVDAGLTKSIGISNFNIKQVEYITKNARIQPVTNQVECNPYL
LNKELSDFCKSKNIVITAYSPLGSPGRPWATPDDRVLLKEPKLLEIAQKHNKTPAQILIR
YQIQRGHVVIPKSVTKDRIISNFDVFNFTLSDSEIKDLENFNYTERICSMSQDKHHPAYP
FNDDA
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 13 | g12728.t17 | Gene3D | G3DSA:3.20.20.100 | - | 8 | 305 | 1.9E-124 |
| 2 | g12728.t17 | PANTHER | PTHR11732:SF294 | ALDO-KETO REDUCTASE FAMILY 1 MEMBER B1 | 12 | 303 | 8.5E-116 |
| 3 | g12728.t17 | PANTHER | PTHR11732 | ALDO/KETO REDUCTASE | 12 | 303 | 8.5E-116 |
| 14 | g12728.t17 | PIRSF | PIRSF000097 | AKR | 8 | 305 | 2.9E-119 |
| 6 | g12728.t17 | PRINTS | PR00069 | Aldo-keto reductase signature | 26 | 50 | 4.6E-57 |
| 4 | g12728.t17 | PRINTS | PR00069 | Aldo-keto reductase signature | 86 | 104 | 4.6E-57 |
| 5 | g12728.t17 | PRINTS | PR00069 | Aldo-keto reductase signature | 136 | 153 | 4.6E-57 |
| 7 | g12728.t17 | PRINTS | PR00069 | Aldo-keto reductase signature | 170 | 199 | 4.6E-57 |
| 8 | g12728.t17 | PRINTS | PR00069 | Aldo-keto reductase signature | 217 | 241 | 4.6E-57 |
| 1 | g12728.t17 | Pfam | PF00248 | Aldo/keto reductase family | 19 | 280 | 6.7E-53 |
| 11 | g12728.t17 | ProSitePatterns | PS00798 | Aldo/keto reductase family signature 1. | 30 | 47 | - |
| 10 | g12728.t17 | ProSitePatterns | PS00062 | Aldo/keto reductase family signature 2. | 136 | 153 | - |
| 12 | g12728.t17 | ProSitePatterns | PS00063 | Aldo/keto reductase family putative active site signature. | 250 | 265 | - |
| 9 | g12728.t17 | SUPERFAMILY | SSF51430 | NAD(P)-linked oxidoreductase | 14 | 299 | 6.02E-92 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0047834 | D-threo-aldose 1-dehydrogenase activity | MF |
| GO:0055114 | NA | NA |
| GO:0016491 | oxidoreductase activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed